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EUS-guided cyanoacrylate injection reduces rebleering rates compared to direct endoscopic cyanoacrylate for gastric varicesEUS guided injections lower rebleeding rates for gastric varices

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Key Takeaway
Note that EUS-guided cyanoacrylate may reduce rebleeding rates compared to direct endoscopic cyanoacrylate.

This systematic review and network meta-analysis evaluated various interventions for gastric varices, including endoscopic cyanoacrylate, thrombin, and EUS-guided techniques. The analysis included 760 patients to compare rebleeding rates, complete obliteration, and adverse event rates across several modalities.

Key findings indicate that EUS-guided cyanoacrylate injection significantly reduced rebleeding rates compared to direct endoscopic cyanacrylate injection (RR 0.39; 95%CI 0.27-0.58). Additionally, EUS-guided coil plus cyanoacrylate injection showed a significantly lower rebleeding rate compared to direct endoscopic cyanoacrylate (RR 0.15; 95%CI 0.03-0.90). Regarding safety, EUS-guided cyanoacrylate, large-volume band ligation, and thrombin injection all demonstrated lower adverse event rates compared to endoscopic cyanoacrylate injection (RR 0.59, RR 0.38, and RR 0.30, respectively).

While these results suggest potential advantages for EUS-guided techniques, the authors note that the quality of evidence is very low. No significant differences were found regarding the complete obliteration of gastric varices among the treatments. Due to the low evidence quality, further randomized controlled trials are needed before firm conclusions can be drawn regarding the relative efficacy and safety of these treatments.

How this fits prior evidence

This finding extends the evidence that endoscopic cyanoacrylate is a standard treatment for gastric varices. It specifically addresses a gap by comparing EUS-guided techniques to traditional endoscopic methods. While prior evidence noted that endovascular interventions reduce rebleeding risk compared to endoscopic cyanoacrylate, this study adds evidence that EUS-guided cyanoacrylate (with or without coils) also shows a lower rebleeding rate than direct endoscopic cyanoacrylate.

Living with gastric varices is dangerous because these enlarged veins in the stomach can bleed unexpectedly. Doctors have several ways to treat them, but finding the safest and most effective method is vital for patient safety. This review looked at data from 760 patients to compare different treatment methods.

Researchers found that using an endoscopic ultrasound (EUS) to guide cyanoacrylate injections led to significantly lower rebleeding rates compared to standard endoscopic injections. Specifically, combining EUS-guided injections with coils also showed a much lower risk of bleeding again. While several treatments were compared, the study did not find one specific method to be significantly better at completely closing the veins.

Safety is another major concern for patients. The study found that EUS-guided injections, thrombin injections, and large-volume band ligation all had lower rates of adverse events than standard endoscopic cyanoacrylate injections. However, it is important to note that the quality of the evidence was very low. Because the data is limited, more high-quality trials are needed before doctors can make firm conclusions about which treatment is best.

What this means for you:
EUS-guided injections may lower rebleeding rates and reduce side effects for patients with gastric varices.

Common questions

Is EUS-guided injection safer than standard methods?

Yes, the study found that EUS-guided cyanoacrylate injection had lower adverse event rates compared with endoscopic cyanoacrylate injection. Other methods, like thrombin injection and large-volume band ligation, also showed lower adverse event rates than the standard endoscopic cyanoacrylate injection.

How effective is EUS-guided injection at stopping bleeding?

The study found that EUS-guided cyanoacrylate injection showed significantly lower rates of rebleeding than direct endoscopic cyanoacrylate injection. When combined with coils, the EUS-guided injection showed even lower rates of rebleeding. However, no treatment was found to be significantly better at the complete obliteration of gastric varices.

Is this finding certain enough to change treatment?

The evidence for these findings is currently very low. Because the quality of evidence is low, more clinical trials are needed before doctors can make firm conclusions about the best treatment for gastric varices.

Study Details

Study typeSystematic review
Sample sizen = 760
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
BACKGROUND: The best endoscopic treatment for gastric varices is currently unclear. We performed a network meta-analysis combining direct and indirect comparisons among the different techniques currently in use. METHODS: We identified 10 randomized controlled trials (RCTs; 760 patients) comparing endoscopic cyanoacrylate injection, endoscopic thrombin injection, endoscopic ultrasound (EUS)-guided cyanoacrylate injection, EUS-guided coil injection, EUS-guided coil+cyanoacrylate injection, and large-volume band ligation. The primary outcome was rebleeding rate, and secondary outcomes were complete obliteration of gastric varices and adverse event rate. The results were expressed in terms of risk ratio (RR) with 95%CIs. RESULTS: EUS-guided cyanoacrylate and EUS-guided coil+cyanoacrylate injection showed significantly lower rates of rebleeding than direct endoscopic cyanoacrylate injection (RR 0.39, 95%CI 0.27-0.58 and RR 0.15, 95%CI 0.03-0.90, respectively). None of the treatments were significantly superior in terms of complete obliteration of gastric varices but EUS-guided cyanoacrylate injection, large-volume band ligation, and thrombin injection had lower adverse event rates compared with endoscopic cyanoacrylate injection (RR 0.59, 95%CI 0.48-0.72; RR 0.38, 95%CI 0.19-0.75; and RR 0.30, 95%CI 0.15-0.61, respectively). CONCLUSIONS: EUS-guided cyanoacrylate injection with or without coils was associated with lower rebleeding rates than conventional endoscopic cyanoacrylate injection. However, the quality of evidence was very low and further RCTs are needed before firm conclusions can be drawn regarding the relative efficacy and safety of these treatments.
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