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Multi-omics technologies and Artificial Intelligence facilitate biomarker screening and target prediction in aging researchAI and multi-omics tools may help target aging processes

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Key Takeaway
Note that multi-omics and AI offer potential for target prediction and biomarker screening in anti-aging research.

This systematic review explores the roles of multi-omics technologies and Artificial Intelligence (AI) in the context of aging research. The scope includes evaluating how these computational and biological tools can be integrated to identify biomarkers, elucidate underlying mechanisms, and facilitate high-throughput screening.

Key findings indicate that multi-omics applications are utilized for biomarker screening and mechanism elucidation. Concurrently, AI applications are used for target prediction, virtual screening, and the design of clinical trials. These technologies aim to support the development of precision anti-aging drugs and personalized treatment strategies.

The authors note significant limitations regarding data standardization and ethical controversies surrounding these technologies. It is important to note that this review discusses theoretical frameworks and potential pathways; it does not provide specific drug efficacy results or clinical trial data. The practical application of these tools remains in the research and development phase rather than established clinical practice.

How this fits prior evidence

This systematic review addresses a gap by exploring technological integration for precision medicine. It complements existing evidence regarding metabolic-epigenetic aging, such as NAD+ restoration and carbonyl stress reduction, by providing a framework for identifying new targets via AI and multi-omics. While previous coverage focused on specific biochemical pathways like lactylation or gut microbes, this review focuses on the computational tools used to identify such interventions.

Aging is a complex process that affects every part of our bodies. Because it involves so many different biological systems, finding specific ways to slow it down has been difficult. Researchers are now looking at how advanced technology can simplify this search.

By using multi-omics technologies, scientists can screen for biomarkers and better understand the underlying mechanisms of aging. When they combine these tools with Artificial Intelligence (AI), they can predict new targets, perform virtual screenings, and design trials more effectively. This approach helps move toward personalized treatment strategies rather than one size fits all solutions.

It is important to note that this research focuses on theoretical frameworks and potential pathways. The study does not provide results from clinical trials or data on specific drug success. Additionally, the field still faces hurdles like ethical concerns and the need for better data standards.

What this means for you:
AI and multi-omics tools can help identify new targets for personalized anti-aging drugs.

Common questions

What is the role of Artificial Intelligence in aging research?

Artificial Intelligence (AI) is used to help scientists predict potential targets, perform virtual screenings, and design clinical trials. By using these tools, researchers can more efficiently identify ways to intervene in the aging process.

What are multi-omics technologies?

Multi-omics refers to a set of technologies used for biomarker screening, explaining biological mechanisms, and high-throughput screening. These tools help researchers see a broader picture of how biology works as we age.

Are these methods currently being used to treat patients?

The current research focuses on theoretical frameworks and potential pathways for drug development. It does not provide clinical trial data or specific results on how well any particular drug works for patients yet.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
The intensifying global population aging has rendered the development of anti-aging drugs a core challenge in the life sciences domain. Traditional models struggle to address the systemic and networked nature of aging. Multi-omics technologies provide a panoramic perspective for deciphering molecular networks of aging, while Artificial Intelligence (AI) has demonstrated significant advantages in target discovery, drug screening, and clinical trial optimization. This review systematically elaborates on the pathological characteristics and molecular mechanisms of aging, analyzes the application paradigms of multi-omics in biomarker screening, mechanism elucidation, and high-throughput screening, and discusses the core value and technical bottlenecks of AI in target prediction, virtual screening, and trial design. Simultaneously, this paper addresses critical challenges including ethical controversies and data standardization currently confronting the field, and explores the prospects of precision anti-aging drug development and personalized treatment strategies driven by deep integration of multi-omics and AI. This approach offers novel theoretical frameworks and practical pathways for extending human healthspan.
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