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Otago Exercise Program improves knee function and mobility after total knee arthroplasty in meta-analysisOtago Exercise Program Shows Promise for Recovery After Knee Replacement Surgery

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Key Takeaway
Consider Otago Exercise Program elements for TKA rehab, but evidence requires validation.

This systematic review and meta-analysis examined the effectiveness of the Otago Exercise Program (OEP) versus conventional rehabilitation for patients recovering from total knee arthroplasty (TKA). The analysis synthesized data from randomized controlled trials (RCTs) involving a total of 1,088 participants. The specific clinical setting (e.g., inpatient, outpatient, home-based) was not reported. The evidence quality was assessed using GRADE methodology, risk of bias was evaluated with the Cochrane Handbook, and publication bias was examined using Egger's test, establishing a structured framework for evaluating the findings.

The intervention was the Otago Exercise Program, a structured regimen of strength and balance exercises. The comparator was conventional rehabilitation, though the specific protocols for either arm were not detailed in the provided data. The frequency and duration of the OEP were explored in subgroup analyses. The primary follow-up period for the analyzed outcomes was 1.0 month post-intervention.

For the primary outcome of knee joint function, the OEP showed a significant improvement compared to conventional rehabilitation. The standardized mean difference (SMD) was 1.80 (95% CI: 0.80, 2.79) for programs with a frequency of 3 or fewer sessions per week. For programs with a duration longer than 1 month, the SMD was 2.57 (95% CI: 0.51, 4.64). Absolute numbers for these outcomes were not reported. Key secondary outcomes also demonstrated improvements: knee flexion angle increased by a mean difference (MD) of 11.24 degrees (95% CI: 9.16, 13.32), balance improved by an MD of 3.45 (95% CI: 2.50, 4.40), fall efficacy improved with an SMD of 0.61 (95% CI: 0.43, 0.79), and functional capacity improved with an SMD of 0.99 (95% CI: 0.80, 1.18). Reductions in pain and joint swelling were indicated based on descriptive analysis, but no specific effect sizes, confidence intervals, or p-values were reported for these endpoints.

Detailed safety and tolerability findings were not reported. The analysis did not provide data on adverse events, serious adverse events, discontinuation rates, or general tolerability of the Otago Exercise Program compared to conventional care. This represents a significant gap in the evidence base for clinical decision-making.

This meta-analysis contributes to the broader evidence on post-TKA rehabilitation by quantitatively synthesizing RCT data for a specific, structured exercise program. Many prior landmark studies and guidelines emphasize early mobilization and physiotherapy, but this analysis attempts to define the potential added value of the OEP's particular focus on strength and balance. The reported effect sizes for function and mobility are notably large, which merits careful scrutiny in the context of the study's limitations.

The analysis has several key methodological limitations. The authors explicitly state that further high-quality, large-scale RCTs are required to validate the effects. The subgroup analyses for exercise frequency and duration are based on a limited number of studies and yield very wide confidence intervals (e.g., 0.51 to 4.64), indicating substantial uncertainty. Outcomes for pain and joint swelling were derived from descriptive analysis only, lacking robust statistical synthesis. Furthermore, the reporting lacks absolute event rates or participant numbers for outcomes, relying solely on summary effect measures, which limits clinical interpretability.

The clinical implications are tentative. The results suggest the Otago Exercise Program may be a beneficial component of rehabilitation for some patients after TKA, particularly for improving objective measures of knee flexion and balance. However, given the evidence limitations—especially the lack of safety data, the uncertain optimal dosing (frequency/duration), and the need for validation—it should not yet be considered a standard-of-care replacement for conventional therapy. It may be reasonable to consider elements of the program for patients where improving balance and functional capacity are prioritized goals.

Several important questions remain unanswered. The optimal protocol for the OEP after TKA—including specific exercises, session frequency, total duration, and timing of initiation—is not defined. The safety profile and comparative risk of adverse events are unknown. The long-term benefits beyond 1 month are not established. Furthermore, the efficacy in specific patient subgroups (e.g., by age, comorbidities, or preoperative function) and the cost-effectiveness compared to standard rehabilitation have not been evaluated.

This research matters to anyone facing or recovering from a total knee replacement, a common surgery for severe arthritis. Recovery can be challenging, involving pain, stiffness, and difficulty with daily activities. Finding the most effective rehabilitation program is crucial for getting back on your feet. This study looked at whether a specific, structured exercise program could offer better results than conventional physical therapy, which could mean a smoother and more complete recovery for many patients.

The researchers conducted a systematic review and meta-analysis, which means they carefully gathered and combined the results from multiple smaller, high-quality studies called randomized controlled trials. In total, they analyzed data from 1,088 patients who had undergone total knee replacement. These patients were divided into groups: some followed the Otago Exercise Program, while others received conventional rehabilitation. The researchers then compared outcomes like knee function, range of motion, balance, and pain about one month after surgery to see which approach worked better.

The combined results suggest the Otago program may be more effective. For key measures like overall knee joint function, the program showed significant improvement, especially when exercises were done for longer than one month. The analysis found that knee bending (flexion) improved by an average of about 11 degrees more in the Otago group. Balance scores also improved by a notable margin. Patients reported feeling more confident about not falling and showed better functional capacity for daily tasks. There were also indications of reduced pain and swelling, though this data was less complete. It's important to understand that these 'effect sizes' (like SMD=2.57) are statistical measures comparing groups; they suggest a meaningful difference, but not a guarantee for every individual.

A significant caution from this review is that safety information was not reported in the included studies. We do not know if there were any adverse events, serious problems, or if people dropped out due to difficulty with the exercises. The tolerability and practical challenges of following this specific program at home are also unknown. Always consult with your surgeon or physical therapist before starting any new exercise regimen after surgery to ensure it is safe for your specific situation.

There are important reasons not to overreact to this single analysis. The researchers themselves note that more high-quality, large-scale trials are needed to validate these effects. Some of the most promising results, like the large improvement in function for longer program duration, come from looking at subgroups of studies, which can be less reliable. The confidence intervals for these results were very wide, meaning the true benefit could be smaller or larger than estimated. Furthermore, the findings on pain and swelling were based only on descriptive analysis, not the stronger statistical combination used for other outcomes. The short, one-month follow-up also means we don't know if these benefits last over the long term.

Realistically, for patients right now, this study highlights the Otago Exercise Program as a potentially superior rehabilitation option that deserves further investigation. It does not mean conventional rehab is ineffective or that every patient must switch to this program. If you are preparing for or recovering from knee replacement surgery, you can discuss this research with your healthcare team. Ask your physical therapist if they are familiar with the Otago program and whether its principles of strength, balance, and fall prevention could be incorporated into your personalized recovery plan. The most important step is to follow a guided, consistent rehabilitation program approved by your medical team, as commitment to post-surgery exercises is one of the strongest predictors of a good outcome.

What this means for you:
A structured exercise program may improve recovery after knee replacement, but more research is needed to confirm.

Study Details

Study typeMeta analysis
Sample sizen = 1,088
EvidenceLevel 1
Follow-up1.0 mo
PublishedApr 2026
View Original Abstract ↓
BACKGROUND: Altered muscle activation patterns are observed in patients undergoing total knee arthroplasty (TKA), resulting in reduced knee joint function, impaired balance, and an increased risk of falls during postoperative recovery. The Otago Exercise Program (OEP) is a rehabilitative intervention designed to enhance muscle strength and improve balance. However, its efficacy in restoring knee joint function and balance in TKA patients remains unclear, with limited clinical evidence. This systematic review and meta-analysis aim to evaluate the effectiveness of OEP on knee joint function, balance, and other recovery outcomes in TKA patients while identifying its essential exercise components. OBJECTIVE: To investigate the effects of the Otago Exercise Program on knee joint function, knee flexion angle, balance, fall efficacy, functional capacity, pain, and joint swelling in patients following total knee arthroplasty. METHODS: Randomized controlled trials (RCTs) examining the effects of the Otago Exercise Program on knee joint recovery in TKA patients were systematically retrieved from Web of Science, PubMed, Cochrane Library, Google Scholar, Embase, CKNI, and KISS databases. The search included studies published from database inception to November 30, 2024. Relevant references from the included studies were manually screened to supplement the literature. Two researchers independently conducted the search, screening, and data extraction. The risk of bias was independently assessed using the Cochrane Handbook, and publication bias was evaluated using Egger's test. Meta-analysis, including subgroup analyses, was performed using Review Manager 5.3. The continuous outcomes were analyzed by calculating the mean difference (MD) or standardized mean difference (SMD) with 95% confidence intervals (CI) according to whether combining outcomes were measured on different scales or not. The quality of evidence in this study was assessed according to the GRADE methodology. RESULTS: A total of 12 RCTs involving 1088 participants were included. Compared to conventional rehabilitation, the Otago Exercise Program significantly improved knee joint function. Subgroup analysis revealed that interventions with a frequency of ≤3 sessions per week (SMD = 1.80, 95% CI: [0.80, 2.79]) and a duration of >1 month (SMD = 2.57, 95% CI: [0.51, 4.64]) yielded larger effect sizes and better outcomes. Additionally, improvements were observed in knee flexion angle (MD = 11.24, 95% CI: [9.16, 13.32]), balance (MD = 3.45, 95% CI: [2.50, 4.40]), fall efficacy (SMD = 0.61, 95% CI: [0.43, 0.79]), and functional capacity (SMD = 0.99, 95% CI: [0.80, 1.18]). Descriptive analysis also indicated reductions in pain and joint swelling. CONCLUSION: This meta-analysis demonstrates that the Otago Exercise Program significantly enhances knee joint function, knee flexion angle, balance, fall efficacy, and functional capacity in TKA patients while also alleviating pain and joint swelling. However, further high-quality, large-scale randomized controlled trials are required to validate the effects of the Otago Exercise Program on knee joint recovery in this population.
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