Mode
Text Size
Log in / Sign up

Adjunctive corticosteroids may modestly reduce hospital stay for bacterial facial infections but evidence certainty is lowAdding steroids to facial infection treatment may shorten hospital stays by about one and a half days

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note low-certainty evidence suggests adjunctive corticosteroids may reduce hospital stay for bacterial facial infections.

This systematic review and meta-analysis investigated the use of adjunctive corticosteroid therapy compared with standard treatment alone for patients suffering from bacterial facial infections. The analysis included a substantial number of participants across various settings. The primary focus was on the duration of hospital stay, with secondary attention given to inflammatory markers, surgical requirements, intensive care unit admissions, and airway complications.

The main results indicated that hospital stay was significantly reduced in the groups receiving corticosteroids. However, pre-treatment C-reactive protein levels were higher in these groups. There were no significant differences observed regarding the number of surgeries performed, intensive care unit admissions, or instances of airway compromise between the treatment arms.

The authors highlight several important limitations, noting that the certainty of evidence is low to very low for all outcomes. Hospital stay data were rated low due to methodological limitations, while other outcomes faced very low-certainty ratings. The study population was predominantly derived from non-randomized studies, contributing to a high risk of bias. Safety data such as adverse events were not reported in the included studies.

Given the low level of evidence and high risk of bias, the clinical relevance is tempered. The authors suggest that while an association with reduced hospital stay exists, causation cannot be firmly established. Further well-designed, randomized, and prospective comparative studies are needed to confirm these findings before altering standard practice.

People with bacterial facial infections often face a tough recovery. These infections can happen after dental work or trauma and sometimes require hospitalization. Doctors want to help patients heal faster and go home sooner. A new analysis looked at whether adding corticosteroids to standard treatment helps. Corticosteroids are powerful anti-inflammatory drugs that reduce swelling. This review combined data from many studies involving 13,905 patients to see if this extra step made a difference.

The researchers found that patients who received corticosteroids alongside standard care stayed in the hospital for an average of 1.61 fewer days. This is a meaningful reduction for someone trying to return to work or family life. The study also looked at other measures like blood markers and the need for surgery. It found no significant difference in the number of surgeries needed. There was also no difference in ICU admissions or airway problems. These results suggest the drug does not cause major safety issues like breathing trouble in this specific group.

However, there are important reasons to be cautious. The certainty of the evidence for all outcomes was rated as low or very low. This means the results could change if more data becomes available. The review noted a high risk of bias in the studies used. Many of the studies were not randomized, which can skew results. Because of this, we cannot say for sure that the steroids caused the shorter stays. We only know there is an association between the treatment and the outcome.

Doctors should not change their practice based on this single review. The low level of evidence means we need more well-designed studies to confirm these findings. We need randomized trials that follow patients carefully to understand the true benefits and risks. Until then, the current standard of care remains the best option. Patients should talk to their doctors about their specific situation. Every infection is different, and what works for one person might not work for another.

This research highlights the complexity of treating infections. It shows that even when a treatment seems promising, we must be careful about how we interpret the data. The goal is always to help patients heal safely and quickly. We need more high-quality research to guide our decisions. For now, the best advice is to follow established guidelines and discuss any new options with a trusted healthcare provider.

What this means for you:
Low-certainty evidence suggests steroids may shorten hospital stays, but more research is needed before changing treatment.

Study Details

Study typeMeta analysis
Sample sizen = 13,905
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
BACKGROUND: Objectives: To evaluate the clinical effectiveness and safety of adjunctive corticosteroid versus standard treatment alone in facial infections. METHODS: Eligibility criteria: Included clinical comparative studies (randomized or non-randomized) evaluating adjunctive corticosteroids versus standard care in patients with bacterial facial infections such as odontogenic/facial space infections, dental abscesses, orbital cellulitis, periorbital cellulitis, and Ludwig's angina. INFORMATION SOURCES: An unrestricted literature search of five databases was conducted up to December 15, 2025. Risk of bias: The quality assessment of the studies was conducted using the Cochrane Risk of Bias Tool (ROBINS-I) for non-randomized and a new risk of bias tool (RoB-2) for randomized studies. SYNTHESIS OF RESULTS: Random effects meta-analyses using mean difference (MD) or standardized mean differences (SMDs) were performed, followed by sensitivity analyses, and assessment of the quality of evidence using GRADE. RESULTS: Included studies: Fifteen comparative studies (three randomized and 12 non-randomized) including 13,905 patients with bacterial facial infections (61.5% male) were included. SYNTHESIS OF RESULTS: Low-certainty evidence showed that the use of adjunctive steroids significantly reduced hospital stay compared with standard treatment alone (10 studies; MD = -1.61 [-3.17, -0.05] days; p = 0.04; I = 99.3%). Low-certainty evidence also showed that pre-treatment CRP was higher in the steroid groups (3 studies; SMD = 0.33 [0.09, 0.58]; p = 0.03; I = 0%). Low-certainty evidence indicated no significant difference in the number of surgeries (p = 0.13), while very low-certainty evidence showed no significant differences in intensive care unit admissions (p = 0.07) or airway compromise (p = 0.18). Sensitivity and subgroup analyses showed no significant differences by study design, infection type, or risk of bias, confirming robust results; only ethnicity had a significant effect on hospital stay (p = 0.0027). DISCUSSION: Limitations of evidence: Certainty of evidence was low to very low for all outcomes, with hospital stay rated low due to methodological limitations, high risk of bias, and the predominance of non-randomized studies. INTERPRETATION: The low level of evidence suggests that adjunctive corticosteroids may provide a reduction in hospital length of stay for patients with bacterial facial infections. Further well-designed, randomized, and prospective comparative studies are needed to confirm these findings. PROPSERO Registration Number: (CRD420261329331).
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.