TCM-based extracts reduce pain in oral lichen planus by 0.86 points on VASTCM Biological Extracts May Reduce Pain in Oral Lichen Planus

This meta-analysis pooled data from 22 articles to evaluate the effect of traditional Chinese Medicine (TCM)-based biological extracts on pain in patients with oral lichen planus (OLP). The primary outcome was visual analog scale (VAS) scores. The analysis found a statistically significant reduction in VAS scores with TCM-based biological extracts, with a mean difference of -0.86 (95% CI: -1.36 to -0.37, P < 0.05).

The review did not report the comparator used, sample size, follow-up duration, or details on adverse events, serious adverse events, or discontinuations. The authors did not specify limitations or practice relevance. As a network meta-analysis, the results are based on pooled data from multiple trials, but the lack of reported safety and comparator information limits the applicability of these findings.

Clinicians should interpret these results cautiously given the incomplete reporting. The modest effect size suggests potential benefit, but further well-reported trials are needed to confirm efficacy and safety.