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High-volume interval exercise linked to higher enjoyment in people with HIV versus healthy controls

High-volume interval exercise linked to higher enjoyment in people with HIV versus healthy controls
Photo by Rajesh Rajput / Unsplash
Key Takeaway
Consider high-volume interval exercise as a potentially enjoyable option for people with HIV, but evidence is preliminary.

This single-blind, counterbalanced, crossover study included 11 people living with HIV and 11 healthy controls to compare exercise enjoyment and related outcomes across three exercise modalities: low-volume high-intensity interval exercise (HIIE-LV), high-volume high-intensity interval exercise (HIIE-HV), and moderate-intensity continuous exercise (MICE). The primary outcome was exercise enjoyment, with secondary outcomes including affective response, future exercise intention (FEI), and rating of perceived exertion (RPE).

Main results showed that exercise enjoyment was higher following HIIE-HV in people living with HIV compared to healthy controls (p = 0.031). No between-condition differences were observed in affective response or FEI in the HIV group. Affective responses during exercise did not differ between modalities in people with HIV, but healthy controls reported lower affective responses during HIIE-HV compared to HIIE-LV and MICE. RPE was significantly higher during HIIE-HV than HIIE-LV and MICE in both groups (p < 0.05).

Safety and tolerability data indicated that people living with HIV reported higher exercise enjoyment following HIIE-HV, suggesting this modality may be well tolerated and positively perceived in this population. Key limitations include a small sample size of 11 per group, which limits generalizability, and the crossover design may introduce carryover effects. Practice relevance is restrained; these findings highlight HIIE-HV as a potentially enjoyable option for people with HIV, but larger, longer-term studies are needed to confirm benefits and assess adherence.

Study Details

Study typeRct
EvidenceLevel 2
PublishedApr 2026
View Original Abstract ↓
AIM: This study compared acute psychological responses to a single session of low-volume high-intensity interval exercise (HIIE-LV), high-volume high-intensity interval exercise (HIIE-HV), and moderate-intensity continuous exercise (MICE) in people living with HIV, and healthy controls using a randomized, counterbalanced crossover design. METHODS: The participants (people living with HIV, and healthy controls) completed three exercise sessions in randomized order: HIIE-HV (4 × 4 min at 80% of maximal power output [W]), HIIE-LV (10 × 60 s at 90% W), and MICE (30 min at 60% W). Psychological outcomes included affective response assessed by the Feeling Scale, exercise enjoyment and future exercise intention (FEI), while rating of perceived exertion (RPE) was recorded throughout the exercise. Data were analysed using repeated-measures ANOVA with the group as a between-subject factor. RESULTS: All participants completed the three exercise conditions and were included in the analyses (11 people living with HIV and 11 healthy controls). In people living with HIV, exercise enjoyment was higher following HIIE-HV compared with healthy controls (p = 0.031). No between-condition differences were observed for affective response or FEI in people living with HIV. During exercise, affective responses did not differ between exercise modalities in people living with HIV, whereas healthy controls reported lower affective responses during HIIE-HV compared with HIIE-LV and MICE. RPE was significantly higher during HIIE-HV compared with HIIE-LV and MICE in both groups (p < 0.05). CONCLUSION: People living with HIV demonstrated similar affective responses and FEI following MICE and HIIE compared with healthy adults, despite higher perceived exertion during HIIE-HV. Notably, people living with HIV reported higher exercise enjoyment following HIIE-HV, suggesting that this exercise modality may be particularly well tolerated and positively perceived in this population.
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