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Home visits and HIV self-testing increase CHTC uptake to 56.2% and 50.0% in pregnant couplesHome visits and self-test kits boost couples HIV testing

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Key Takeaway
Note that both home visits and HIV self-test kits significantly increase CHTC uptake in pregnant couples.

This randomized controlled trial enrolled 800 HIV status-concordant and HIV status-discordant pregnant couples in Kenya. The study evaluated two intervention groups against a standard care group to determine the impact on CHTC uptake by 12 months postpartum. The home visit group received five visits from lay counselors, while the HIV self-test group received kits for use with partners. The standard care group received routine perinatal health services and standard testing offers.

Primary outcomes showed that the home visit group had a 56.2% (114/267) CHTC uptake rate, with an adjusted risk ratio of 4.22 (95% CI 2.88-6.18). The HIV self-test group achieved a 50.0% (106/266) uptake rate, with an adjusted risk ratio of 3.69 (95% CI 2.50-5.45). In contrast, the standard care group reported a 13.6% (26/267) uptake rate.

Safety data reported 37 adverse events, with two possibly related to study procedures. Additionally, 54 severe adverse events were recorded, which were identified as adverse pregnancy outcomes not related to study procedures. Follow-up continued for 18 months postpartum. While both interventions significantly increased CHTC uptake compared to standard care, the specific impact on secondary maternal and child health outcomes was not detailed in the primary results. These findings suggest that community-based interventions can improve engagement for perinatal women.

A new study tested two ways to help pregnant couples in Kenya learn their HIV status together. The study included 800 couples from 24 antenatal clinics in Migori and Kisumu counties. Some couples received five home visits from lay counsellors who taught health and relationship skills and offered couples HIV testing at home. Others received HIV self-test kits for women to use with their partners. A third group received standard care, which included routine perinatal services and offers of individual and couples testing at the clinic.

By 12 months after giving birth, couples who got home visits were more than four times as likely to have tested together compared to standard care. Couples who got self-test kits were more than three times as likely. Specifically, 56.2% of the home visit group and 50.0% of the self-test group had tested together, versus only 13.6% in the standard care group.

The study followed families until 18 months after birth and also looked at health outcomes for mothers and children. There were 37 adverse events, with two possibly related to study procedures. There were also 54 severe adverse events, all related to pregnancy outcomes and none linked to the study procedures.

This was a randomized controlled trial, which is a strong design. However, the results come from one region in Kenya, so they may not apply everywhere. The takeaway is that offering home visits or self-test kits can greatly increase couples HIV testing during pregnancy, which may help improve health for mothers and families.

What this means for you:
Home visits or HIV self-test kits can greatly increase couples HIV testing among pregnant women in Kenya.

Common questions

What is couples HIV testing and why is it important?

Couples HIV testing means both partners learn their HIV status together. It can help prevent transmission between partners and from mother to baby. This study tested ways to increase it among pregnant couples in Kenya.

How did the home visits work?

Lay counsellors visited couples at home five times. They taught health and relationship skills and offered couples HIV testing right at home. This approach led to 56.2% of couples testing together, compared to 13.6% with standard care.

Were there any safety concerns?

The study reported 37 adverse events, with two possibly related to study procedures. There were also 54 severe adverse events, all related to pregnancy outcomes and none linked to the study procedures.

Study Details

Study typeRct
Sample sizen = 267
EvidenceLevel 2
Follow-up180.0 mo
PublishedSep 2026
View Original Abstract ↓
BACKGROUND: Engaging couples during pregnancy can improve HIV prevention and family health. We examined the effectiveness of two couples-focused interventions on uptake of couples HIV testing and counselling (CHTC) and maternal and child health outcomes. METHODS: In this multicentre, couples-based, randomised controlled trial, HIV status-concordant and HIV status-discordant pregnant couples (aged ≥15 years) from 24 antenatal clinics across Migori and Kisumu counties in Kenya were randomly assigned (1:1:1) to one of three study groups: lay counsellors delivered five couple home visits on health and relationship skills and offered CHTC at home (home visit group); HIV self-test kits were given to women to use with their partners (HIV self-test group); standard care access with routine perinatal health services offered at their health facility, including offers of individual and couples HIV testing (standard care group). Couples were followed up to 18 months postpartum. The primary outcome was both couple members reporting CHTC uptake by 12 months postpartum. For analyses, we used generalised linear and generalised estimating equation models. This trial is registered at ClinicalTrials.gov, NCT03547739, and is complete. FINDINGS: Between March 20, 2019, and July 26, 2022, we recruited and randomly assigned 800 couples to the home visit group (n=267), HIV self-test group (n=266), or standard care group (n=267). Two-thirds (n=533 [66·7%]) of couples included a woman living with HIV. CHTC uptake was higher in the home visit group and HIV self-test group, with 114 (56·2%; adjusted risk ratio 4·22 [95% CI 2·88-6·18]) and 106 (50·0%; 3·69 [2·50-5·45]) couples reporting CHTC by 12 months, compared with 26 (13·6%) in the standard care group. We reported 54 severe adverse events (adverse pregnancy outcomes, none related to study procedures) and 37 adverse events (two possibly related to study procedures). INTERPRETATION: Both home visits and HIV self-test kits offer a gateway for positive health outcomes for perinatal women and families. Home visits, which directly engage both members of the couple, can provide additional advantages for HIV-related health. FUNDING: National Institute of Mental Health. TRANSLATION: For the Kiswahili translation of the abstract see Supplementary Materials section.
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