This systematic and bibliometric review analyzed existing literature on alternatives to antibiotics in aquaculture, specifically examining the antimicrobial and antioxidant mechanisms of probiotics and prebiotics. The review extracted 1,475 research articles, reviews, and book chapters for analysis, with bibliometric data showing India (67 publications), China (50), and the United States (36) as the most prolific contributors. The most frequent keywords identified were 'probiotics,' 'prebiotics,' and 'aquaculture.'
The review summarized that probiotics and prebiotics as feed additives have a positive effect on immune responses, disease resistance, growth performance, and tolerance against abiotic stressors in aquatic species. The authors reported beneficial effects on feed quality and animal health. However, no specific effect sizes, absolute numbers for clinical outcomes, p-values, or confidence intervals were reported for these health effects.
Safety and tolerability data were not reported in this review. Key limitations were not explicitly stated by the authors, but the review's methodology note clarifies that findings are based on summarizing existing literature without presenting new primary data or meta-analysis results. The practice relevance statement notes that farmers in aquaculture were encouraged to use alternative disease prevention strategies. Clinicians should recognize this as a high-level summary of reported associations in aquaculture research, not as direct evidence applicable to human medicine.
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BackgroundThe aquaculture industry has prominent role in the commercial production of fish protein needs of the world. Various technologies have emerged to improve the aquaculture industry. The alternative strategies for antibiotics and chemicals used in aquaculture to treat infectious disease are the potential probiotics and plant-derived prebiotics. As a result, farmers who depend on aquaculture were encouraged to use alternative strategies to prevent diseases. This review focuses on the effect of the antimicrobial and antioxidant properties of the prebiotic and probiotic bacterial strains on the aquatic pathogens.MethodsThe systematic search related to probiotics and prebiotic effect on the aquaculture industry from Scopus databases was retrieved to identify the years of publications, countries from which it was published from 2015 to 2025. The bibliometric analysis performed provided comprehensive and detailed scientific data using quantitative tools like VOSviewer software.ResultsA total of 339 publications and book chapters from the year 2005 to 2025 were retrieved for a major part of bibliometric analysis. A total of 1,475 research articles, reviews and book chapters were extracted for the VOS viewer networking. The countries from which maximum more research articles are India, China, and United States having 67, 50, and 36 publications, respectively. The top current keywords used are “probiotics,” “prebiotics,” and “aquaculture.”ConclusionBoth probiotic and prebiotics bacteria have a positive effect on immune responses, disease resistance, growth performance and tolerance against abiotic stressors of aquatic species is also discussed. The bioactive compounds and antioxidant effect of both probiotic and prebiotic bacteria are reported to have beneficial effects as a feed additive which can improve feed quality and animal health.