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Educational and motivational activities increase HPV vaccine uptake with OR 1.57 in adolescentsEducational activities help more teenagers get the HPV vaccine

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Key Takeaway
Consider educational and motivational activities to improve adolescent HPV vaccine uptake and related attitudes.

This secondary analysis of a randomized trial involved 2758 adolescents aged 13 to 15 years in a school-based setting in France. The study evaluated the impact of educational and motivational activities (EMM) on HPV vaccine uptake and related knowledge, attitudes, and practices (KAP).

The primary outcome was the gain in vaccine uptake or intention during a 5-month follow-up. Results showed that EMM was associated with an increase in uptake (OR: 1.57; 95% CI: 1.02-2.41).

Several factors were identified as significant mediators for the effect of EMM on uptake. These included attitude toward the vaccine's benefit-risk balance (OR: 1.14), vaccine safety (OR: 1.12), accessibility (OR: 1.11), discussing vaccination with friends (OR: 1.11), and self-rated level of knowledge (OR: 1.10).

Safety and tolerability data were not reported. A limitation of this study is that it is a secondary analysis of a larger trial. These findings suggest that multifaceted educational and motivational interventions may be more effective than knowledge-only campaigns for improving vaccine uptake in adolescent populations.

How this fits prior evidence

How this fits prior evidence: This finding addresses a gap in understanding how to improve vaccine uptake. While prior evidence showed that interactive digital assistants may improve short-term HPV vaccine booking and cervical cancer screening uptake, this study specifically highlights the role of educational and motivational activities (EMM) and the mediation of attitudes and knowledge in increasing uptake among adolescents.

Getting teenagers vaccinated against the human papillomavirus (HPV) is a major goal for public health. However, many teens may hesitate because they lack clear information or feel unsure about the vaccine's benefits. This study looked at how specific educational and motivational activities could change those minds.

Researchers analyzed data from 2,758 adolescents aged 13 to 15 in France. They found that students who participated in these educational and motivational activities were more likely to get the vaccine or express an intention to get it. The study also found that several factors helped drive this change, including better knowledge of the vaccine, improved attitudes toward its benefits, and a better understanding of its safety.

While the results are promising, it is important to note that this was a secondary analysis of a larger trial. The study highlights that simply giving facts isn't enough; changing how teens feel about the vaccine's safety and benefits is key to increasing vaccination rates.

What this means for you:
Motivational and educational activities can improve HPV vaccine uptake by improving teen attitudes and knowledge.

Common questions

How did the educational activities affect vaccine uptake?

The study found that educational and motivational activities were associated with a higher likelihood of vaccine uptake or intention among the 2,758 adolescents. Specifically, the results showed an odds ratio of 1.57 for those who participated in these activities compared to those who did not.

What specific factors helped improve vaccine uptake?

Several factors helped drive the increase in vaccine uptake. These included better knowledge of the vaccine, improved attitudes toward the vaccine's benefit-risk balance, better perceptions of vaccine safety, and increased accessibility. Talking about the vaccine with friends also played a role in improving uptake.

Who was included in this study?

The study included 2,758 adolescents between the ages of 13 and 15. The research took place in a school-based setting in France to evaluate how educational and motivational activities influenced their views on the HPV vaccine.

Study Details

Study typeRct
EvidenceLevel 2
PublishedOct 2026
View Original Abstract ↓
BACKGROUND: In France, human papillomavirus vaccine (HPVV) coverage among adolescents remains below the national objective. The PrevHPV randomised trial assessed three intervention components to improve HPVV coverage among adolescents: educational and motivational activities (EMM); vaccination campaigns (FA) in middle schools; and General Practitioner (GP) training. FA increased vaccine uptake, while EMM improved vaccine uptake or intention, as well as HPVV-related knowledge, attitudes, and practices (KAP). This secondary analysis aimed to assess whether the positive effect of EMM on HPVV uptake or intention was mediated by specific KAP improvements. METHODS: A total of 2758 adolescents aged 13 to 15 years from 39 schools completed online questionnaires at baseline and 5 months post-intervention. We created binary variables for the outcome "gain in vaccine uptake or intention during follow-up" and for favourable changes in individual KAP items. We used mediation analyses to evaluate indirect effects of individual KAP items on the association between EMM and uptake/intention, adjusting for FA and GP components and accounting for school-level clustering. RESULTS: EMM was associated with an increase in HPVV uptake or intention (OR:1.57, 95% CI: 1.02-2.41). The strongest significant mediation effects occurred via improved attitudes toward the vaccine's benefit-risk balance (indirect effect OR:1.14), vaccine safety (OR:1.12) and accessibility (OR:1.11), as well as for having discussed HPV vaccination with friends (OR:1.11) and for higher self-rated level of knowledge about the vaccine (OR:1.10). CONCLUSION: These results help understanding the specific positive effects of co-constructed in-class educational activities and underpin the importance of improving vaccine-related attitudes - not only knowledge.
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