Systematic review suggests specific probiotic strains may influence sex hormone related disorders
Photo by National Institute of Allergy and Infectious Diseases / Unsplash
Key Takeaway
Note that specific probiotic strains may assist in managing hormonal imbalances and inflammation via the gut-hormone axis.
This systematic review explores the relationship between probiotics and sex hormone related disorders. The authors focus on the regulatory mechanisms of the bidirectional axis between the gut microbiota and sex hormones, noting that dysregulation of this axis is a critical factor in the pathogenesis of these conditions.
The synthesis of available evidence indicates that specific probiotic strains may provide therapeutic benefits. The authors report that these strains may ameliorate hormonal imbalances, attenuate inflammation, and optimize metabolic parameters. These findings suggest that probiotics could serve as a promising adjunctive therapeutic strategy by targeting the gut microbiota-sex hormone axis.
While the review highlights potential benefits for hormonal, inflammatory, and metabolic health, the specific strains, dosages, and clinical outcomes were not reported in detail within the provided data. The clinical relevance of these findings lies in the potential for adjunctive management of sex hormone related disorders through microbiota modulation.
More on sex hormone related disorders
Bibliometric analysis reveals increasing research trends in intestinal microbiota and chronic wounds
Research shows gut health may help heal chronic wounds
This bibliometric analysis of 553 English articles examines research trends regarding intestinal microbiota and chronic wounds from 2005 to …
New research trends suggest that the bacteria in your gut could play a vital role in healing difficult wounds like diabetic foot ulcers.
Probiotic co-administration with berotralstat improves GI tolerability in HAE patients
Probiotics may help manage side effects of HAE treatment
This pilot case series from six Italian centers evaluated probiotic co-administration with berotralstat in 25 adolescents and adults with he…
New early treatment steps for hereditary angioedema might reduce monthly attacks while keeping stomach issues to a minimum.
Systematic review finds gut microbiota drugs reduce liver enzymes in MASLD patients compared to placebo.
New drugs targeting gut bacteria may finally treat fatty liver disease
This systematic review and network meta-analysis evaluated gut microbiota-regulating drugs, including probiotics, prebiotics, synbiotics, an…
New medicines that change gut bacteria lower liver enzymes in fatty liver patients, offering hope for those struggling with diet and exercis…
Network meta-analysis of dietary supplements for ulcerative colitis management
Some dietary supplements may help ulcerative colitis symptoms and quality of life
This network meta-analysis of 24 randomized controlled trials with 1,491 participants synthesized evidence on dietary supplements for ulcera…
A review of 24 trials found certain supplements like probiotics and flaxseed extract may ease ulcerative colitis symptoms and improve qualit…
View Original Abstract ↓
Sex hormone related disorders, characterized by complex etiology and long-term health risks, pose a significant challenge to global health. Hormone-based therapies are often accompanied by adverse effects and fail to address the underlying pathophysiological mechanisms. The “gut microbiota-sex hormone axis” maintains endocrine homeostasis through diverse pathways, including enzymatic reactions, immune modulation, metabolic regulation, and the microbiome-gut-brain axis. Dysregulation of this axis has been identified as a critical factor in the pathogenesis of sex hormone-related disorders. Probiotics have emerged as a promising adjunctive therapeutic strategy by targeting this axis. Preclinical and clinical studies have demonstrated that specific probiotic strains ameliorate hormonal imbalances, attenuate inflammation, and optimize metabolic parameters, showing positive efficacy in sex hormone-related disorders. This review systematically elaborates the regulatory mechanisms of this bidirectional axis and highlights the application of probiotics and its regulatory roles as targeted interventions in related disorders.
Metformin, fluvoxamine, or ivermectin for non-hospitalized COVID-19 adults in a Phase 3 trial
Metformin Cuts Long Covid Risk by 40%
Related in Infectious Disease
Review of Fluoroquinolone Restriction Implementation Modifications for C. difficile Prevention
Hospital plans to stop risky drugs often changed during real-world rollout
This review analyzes modifications to fluoroquinolone restriction implementation strategies from the FIRST trial across four diverse hospita…
Plans to limit risky fluoroquinolones often changed during rollout. Rural hospitals needed more tweaks than academic centers.
Systematic review and meta-analysis finds bacterial co-infection in 17.3% of hospitalized influenza patients
Hospital data shows high rates of bacterial co-infection in influenza patients
This systematic review and meta-analysis of 111,889 hospital-attended patients with laboratory-confirmed influenza found a pooled prevalence…
Analysis of over 111,000 patients reveals that bacterial co-infection occurs in 17.3% of hospital cases with confirmed influenza infection.
Systematic review examines tumor microenvironment mechanisms in lung cancer brain metastases
New brain strategies target lung cancer before it spreads
This systematic review explores the complex mechanisms driving brain metastasis in patients with lung cancer. The authors synthesize how int…
Doctors are finding clever new ways to fight lung cancer that has spread to the brain without breaking the body's natural barriers
Bibliometric analysis reveals increasing research trends in intestinal microbiota and chronic wounds
Research shows gut health may help heal chronic wounds
This bibliometric analysis of 553 English articles examines research trends regarding intestinal microbiota and chronic wounds from 2005 to …
New research trends suggest that the bacteria in your gut could play a vital role in healing difficult wounds like diabetic foot ulcers.
From Other Specialties
Systematic review and meta-analysis of canonical babbling ratio trajectories in infants aged 5 to 24 months across 42 studies
Babbling grows steadily from five to twenty-four months in babies everywhere
This systematic review and meta-analysis examined canonical babbling ratio (CBR) measurement across 42 studies involving 1277 infants aged 5…
A large review found that babies babble more as they age, with interactive play sessions capturing more sounds than quiet home recordings.
Meta-analysis shows moderate positive learning effects from physically embodied educational robots in classrooms
Classroom Robots Boost Children's Learning, Review Finds
This meta-analysis reviews evidence on the impact of physically embodied educational robots (PERs) on learning outcomes in children. Analysi…
A review of 3665 children finds that physically embodied educational robots moderately improve learning outcomes.
Systematic review meta-analysis shows higher complication rates in young children undergoing tonsillectomy
Young kids under three can safely go home after tonsil surgery
This systematic review and meta-analysis evaluated complications of tonsillectomy or adenotonsillectomy in children aged 2 to 3 years compar…
New research shows toddlers aged two to three can likely go home the same day after having their tonsils removed without extra risk.
Systematic review and meta-analysis supports adalimumab plus methotrexate for JIA-associated uveitis
Combination therapy reduces relapse risk in children with eye inflammation from arthritis
This systematic review and meta-analysis of RCTs evaluated adalimumab plus methotrexate in children with juvenile idiopathic arthritis-assoc…
Combining adalimumab with methotrexate lowers relapse risk and helps reduce steroid use in children with arthritis-related eye inflammation.