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Single-centre observational study on hemodialysis duration and outcomes in end-stage renal diseaseShorter Dialysis Sessions May Offer Better Quality of Life for Older Patients

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Key Takeaway
Consider that less than 720 minutes weekly hemodialysis may improve quality of life without increasing mortality, but evidence is observational and limited.

This is a single-centre observational study in New Brunswick, Canada, examining adults undergoing in-centre or satellite hemodialysis for at least 3 months. The study compared patients receiving less than 720 minutes per week of dialysis to those receiving 720 minutes or more, with a sample size of 140 participants.

The authors found that patients with less than 720 minutes per week had a higher median quality of life score (KDQOL-36 Symptoms/Problems List scale: median 79.2 vs. 70.8, p = 0.0022). They also had fewer emergency department visits (incident rate ratio 0.52, 95% CI 0.33-0.81). Mortality was similar between groups, even when adjusted for age and comorbidity score (odds ratio 1.62, 95% CI 0.59-4.49).

The authors acknowledge limitations, including the single-centre design, limited sample size, no frailty assessment, and no accounting for how long patients had been prescribed less dialysis. They note that a higher number of participants might have identified significant trends in mortality.

Practice relevance is restrained; the results suggest a conservative HD prescribing model may improve quality of life without increasing mortality, but further studies are needed to assess feasibility and safety. Causation cannot be inferred from this observational data.

A Hard Choice

Imagine sitting in a dialysis chair for four hours, three times a week. For many patients with kidney failure, this is a lifelong routine. It can be exhausting, especially for older adults or those managing other health problems.

But what if less time on dialysis could actually make life better?

A new study from New Brunswick, Canada, suggests that for some patients, shorter weekly dialysis sessions might lead to a better quality of life and fewer hospital trips—without raising the risk of death.

Dialysis is a lifeline for people whose kidneys can no longer filter waste from their blood. The standard treatment involves about 12 hours per week, usually split into three sessions.

But this schedule is tough. It can leave patients drained, limit their ability to travel or socialize, and add stress to an already challenging life.

For older patients or those with multiple health conditions, the burden can feel overwhelming. Many wonder if there’s a way to balance treatment with living.

This study explores a simpler question: Can we dialyze less often and still keep patients safe?

The Standard vs. The Shift

Traditionally, doctors prescribe a fixed amount of dialysis time—usually 720 minutes per week. This is based on guidelines aimed at removing enough waste from the blood.

But here’s the twist: Not everyone needs the same amount. Older patients or those with less kidney function might not tolerate long sessions well.

This study looked at what happens when patients get less than the standard weekly time. The goal wasn’t to cut corners, but to personalize care.

How Shorter Time Might Help

Think of dialysis like a traffic jam. The longer you sit, the more stress builds up. For some patients, shorter sessions might reduce that stress, giving their bodies a break.

The study focused on a key measure: quality of life. This includes how patients feel physically and emotionally, and how symptoms affect their daily activities.

Patients on shorter dialysis reported fewer symptoms and problems. They also visited the emergency room less often.

This suggests that less time on dialysis might not just be easier—it could be healthier for some.

A Closer Look at the Study

Researchers in New Brunswick followed 140 patients on in-center dialysis. All had been on dialysis for at least three months.

They divided patients into two groups:

  • Group 1: 99 patients receiving 720 minutes or more per week.
  • Group 2: 41 patients receiving less than 720 minutes per week.

Patients completed a quality-of-life survey called KDQOL-36. The team also tracked emergency visits, hospital stays, and deaths over time.

The shorter-dialysis group was older—median age 76 vs. 64 in the standard group. This is important because older patients often have more health challenges.

Despite this, the shorter-dialysis group had better quality-of-life scores on the symptoms and problems scale. Their average score was 79.2, compared to 70.8 in the standard group.

They also had fewer emergency room visits. The risk of an ER trip was about half for the shorter-dialysis group.

Most importantly, death rates were similar between the groups. Even after adjusting for age and other health issues, there was no clear difference in survival.

But Here’s the Catch

This doesn’t mean shorter dialysis is right for everyone. The study was small and only included patients from one region.

Also, researchers didn’t track how long patients had been on shorter dialysis. Some might have started recently, while others were on it for years.

This doesn’t mean this treatment is available yet.

What Experts Say

The study’s authors note that shorter dialysis could be part of a “conservative” approach for patients with palliative care goals. This means focusing on comfort and quality of life, not just extending survival.

But they stress that more research is needed. Larger studies could confirm these findings and help identify which patients benefit most.

If you or a loved one is on dialysis, talk to your doctor about your treatment plan. Ask if shorter sessions might be an option.

But don’t make changes on your own. Dialysis is complex, and what works for one person may not work for another.

This study had several weaknesses. It was small and only included patients from one province. Researchers didn’t assess frailty, which can affect outcomes.

Also, as an observational study, it can’t prove cause and effect. It only shows a link between shorter dialysis and better quality of life.

The next step is larger, more diverse studies. Researchers need to test shorter dialysis in different settings and track patients for longer.

If confirmed, this approach could help personalize dialysis care—giving older patients a better quality of life without sacrificing safety.

For now, it’s a promising sign that less might sometimes be more.

Study Details

Sample sizen = 140
EvidenceLevel 5
PublishedApr 2026
View Original Abstract ↓
Abstract Background: Life sustaining hemodialysis (HD) is onerous for patients, especially those with multiple co-morbidities and advanced age. A standard HD prescription is 720 minutes per week. Alternative HD regiments have been proposed in attempt to maintain quality of life. Studies are needed to investigate the efficacy and safety of less frequent HD prescriptions in this population. This is an institution-wide observational study in New Brunswick, Canada to compare HD prescriptions and the impact on QOL and mortality. Objective: The purpose of this study is to assess the current HD prescribing practices at a provincial healthcare institution in relation to patient QOL. Design: Prospective Observational Study. Setting: Single centre hospital and satellite hemodialysis units. Patients: Voluntarily consented patients undergoing in-centre hemodialysis treatment. Measurements: Observational clinical data was collected for each study participant from their hospital and dialysis electronic medical records. The KDQOL-36 questionnaire was used to assess patient-reported quality of life at the time of consent. Methods: Adults undergoing in-centre or satellite site HD for at least 3 months were eligible to participate. Consenting patient participants were grouped by HD prescription whether they were prescribed 720 minutes or more per week or less than 720 minutes per week. All participants completed the KDQOL-36 questionnaire to estimate QOL and groups were compared using the Mann-Whitney U statistical test. Emergency department visits, hospitalizations, and mortality were analyzed using a negative binomial regression or a logistic regression. Results: We enrolled 140 patient participants; 41 were undergoing less than 720 minutes per week of HD and 99 were undergoing 720 minutes or more of HD per week. Patients who were undergoing less than 720 minutes per week of HD were older [Median: 76 yrs. vs. 64 yrs., p < 0.001], had higher median QOL scores on the Symptoms/ Problems List scale on the KDQOL-36 questionnaire [79.2 vs. 70.8, p = 0.0022], and were less likely to present to the emergency department (incident rate ratio 0.52, 95% confidence interval [CI] 0.33-0.81). Mortality was similar between groups, even when adjusted for age and comorbidity score (odds ratio 1.62, 95% CI 0.59-4.49). Limitations: Patient participant enrollment was limited by the single centre nature of this study. As this was an observational study, we did not account for how long the patients had been prescribed less than 720 minutes of hemodialysis. We did not include a frailty assessment of the study participants. A higher number of study participants may have identified significant trends in mortality. Conclusions: The results of this study show that patients undergoing less than 720 minutes of weekly HD had a higher QOL score for the KDQOL-36 Symptoms/ Problems List scale, were less frequently in the emergency department and were not more likely to die than patients undergoing 720 minutes or more of weekly HD. Further studies are required to assess the feasibility and safety of a conservative model of HD prescribing to improve QOL of patients with palliative care treatment goals.
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