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Home › Conditions › End Stage Renal Disease

End Stage Renal Disease

Part of Chronic Kidney Disease

15 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for End Stage Renal Disease

136 trials tracked for End Stage Renal Disease: 33 in phase 3 or 4 and 14 with published results. The most-cited published study has 295 citations.

136Trials tracked
33Phase 3 & 4
0Recruiting
14With published results
Phase distribution
Phase 4 17 Phase 3 16 Phase 2 36 Phase 1 12 Other / NA 55
  1. Phase 4 Exploring Renal Transplants Using Hepatitis C Infected Donors for HCV-negative Recipients Completed · 295 cited
  2. Phase 3 Ombitasvir/ABT-450/Ritonavir and Dasabuvir With or Without Ribavirin in HCV Genotype 1-Infected Adults With Chronic Kidney Disease Completed · 278 cited
  3. Phase 4 Trial to Evaluate Anticoagulation Therapy in Hemodialysis Patients With Atrial Fibrillation Completed · 223 cited
  4. Phase 3 A Trial of Sertraline vs. CBT for End-stage Renal Disease Patients With Depression {ASCEND} Completed · 113 cited
  5. Phase 3 Journeys to Wellness: A Transplant Candidate Study Completed · 67 cited
  6. Phase 4 Kidney Transplants in Hepatitis C Negative Recipients With Hepatitis C Viremic Donors Completed · 49 cited
Show 44 more trials
  1. Phase 4 Patiromer Efficacy to Reduce Episodic Hyperkalemia in End Stage Renal Disease Patients Completed · 46 cited
  2. Phase 4 Study Response of 13-valent Conjugate Pneumococcal Vaccine in Patients With End Stage Renal Disease Completed · 37 cited
  3. Phase 3 Safety and Efficacy Study of the Venous Window Needle Guide to Access Arteriovenous (AV)Fistulae Completed · 29 cited
  4. Phase 3 A Study to Evaluate the Safety of Paricalcitol Capsules in Pediatric Subjects Ages 10 to 16 With Stage 5 Chronic Kidney Disease Receiving Peritoneal Dialysis or Hemodialysis Completed · 19 cited
  5. Phase 3 Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis Completed · 19 cited
  6. Phase 4 A Long-Term Study of Tenapanor Alone or in Combination With Sevelamer in Patients With CKD on Dialysis and HP Completed · 17 cited
  7. Phase 3 Comparison of the Human Acellular Vessel (HAV) With ePTFE Grafts as Conduits for Hemodialysis Completed · 12 cited
  8. Phase 4 Effect of Dialysis on the Pharmacokinetics of Telavancin in Patients With Chronic Kidney Disease Stage 5 Completed · 3 cited
  9. Phase 4 Renal Transplants in Hepatitis C Negative Recipients With Nucleic Acid Positive Donors Completed
  10. Phase 4 Trial to Evaluate Safety and Tolerability of Tacrolimus Extended-Release (Astagraf XL) in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients Completed
  11. Phase 4 Triferic AVNU Infusion Via Freedom Pump During Hemodialysis Completed
  12. Phase 4 Ertapenem Pharmacokinetics in Patients in Continuous Ambulatory Peritoneal Dialysis Completed
  13. Phase 4 Improved Induction and Maintenance Immunosuppression in Kidney Transplantation Completed
  14. Phase 4 Safety and Effects of Supplementation With Ergocalciferol on Erythropoietin Dosing in Hemodialysis Patients Completed
  15. Phase 4 Panel Reactive Antibody (PRA) Reduction in Sensitized Patients Awaiting Renal Transplantation Completed
  16. Phase 4 Pharmacokinetics of Single-Dose Oral Ranolazine in Hemodialysis Patients Completed
  17. Phase 4 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed
  18. Phase 4 A Research Study for Patients With End-Stage Renal Disease (ESRD) Completed
  19. Phase 3 A Long-Term Safety Extension Trial of Ferric Citrate in Patients With End-Stage Renal Disease (ESRD) on Dialysis Completed
  20. Phase 3 Efficacy of Sirolimus-Based, Steroid Avoidance Immunosuppression African Americans Completed
  21. Phase 3 Extended Release Tacrolimus vs. Twice-Daily Tacrolimus Completed
  22. Phase 3 Trial to Evaluate the Sirolimus-Eluting Collagen Implant on AV Fistula Outcomes Completed
  23. Phase 3 A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysis Completed
  24. Phase 3 Safety Study of Soluble Ferric Pyrophosphate (SFP) in Dialysate in CKD Patients Receiving Chronic Hemodialysis Completed
  25. Phase 3 A 4-Week Dose-Ranging and Efficacy Trial of KRX-0502 (Ferric Citrate) in Patients With End-Stage Renal Disease Completed
  26. Phase 3 Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients Completed
  27. Phase 3 Evaluation of the GORE® ACUSEAL Vascular Graft for Hemodialysis Access Completed
  28. Phase 2 Safety and Efficacy Study of AB002 (E-WE Thrombin) in End Stage Renal Disease Patients on Chronic Hemodialysis Completed
  29. Phase 2 C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI Completed
  30. Phase 2 A Safety and Tolerability Study of Zerenex (Ferric Citrate) in Patients With End-Stage Renal Disease (ESRD) Completed
  31. Phase 2 Determine the Safety/Efficacy of Ticagrelor for Maintaining Patency of Arterio-Venous Fistulae Created for Hemodialysis Completed
  32. Phase 2 Bone Mass and Strength After Kidney Transplantation Completed
  33. Phase 2 Pharmacokinetics and Optimal Dose of Ertapenem in Hemodialysis Patients Completed
  34. Phase 2 Equivalence of Triferic® (Ferric Pyrophosphate Citrate) Administered Via Hemodialysate and Intravenously to Adult CKD-5HD Patients Completed
  35. Phase 2 Use of Immune Globulin Plus Rituximab for Desensitization in Highly HLA Sensitized Patients Awaiting Deceased Donor Kidney Transplantation Completed
  36. Phase 2 Safety and Dose Finding Study of Xigris in Hemodialysis Patients Completed
  37. Phase 2 16-Week Repeat Oral Dose Study of AKB-6548 for Anemia in Participants With End Stage Renal Disease (ESRD) Requiring Chronic Hemodialysis Completed
  38. Phase 2 Study to Investigate the Safety of a Drug Called Osocimab at Low and High Doses in Adult Patients With Kidney Failure Requiring Regular Hemodialysis Completed
  39. Phase 2 The Effects of Patiromer on Serum Potassium Level and Gut Microbiome of ESRD Patients With Hyperkalemia Completed
  40. Phase 2 Safety Trial of Single Versus Multiple Dose Thymoglobulin Induction in Kidney Transplantation Completed
  41. Phase 2 Study of the Effect of Intradialytic Vasopressin on Chronic Hypertension in Patients With End Stage Renal Disease Completed
  42. Phase 2 Renal Allograft Tolerance Through Mixed Chimerism Completed
  43. Phase 2 Global Study of MK-2060 (Anti-Factor XI Monoclonal Antibody) in Participants With End Stage Renal Disease Receiving Hemodialysis (FXI Hemodialysis Study) (MK-2060-007) Completed
  44. Phase 2 The Effect of an Antibiotic on the Production of Uremic Toxins by the Gut Microbiome Completed

Showing the 50 most-cited and recently-updated of 136 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Risk-adapted HLA delisting and imlifidase enable deceased-donor kidney transplantation for highly sensitized candidates
Infectious Disease Guideline
Risk-adapted HLA delisting and imlifidase enable deceased-donor kidney transplantation for highly sensitized candidates New guide helps transplant kidneys for hardest-to-match patients
This expert consensus provides a practical guideline for managing highly sensitized adult patients on the waitlist for deceased-donor kidney…
A new expert guide shows how to safely transplant kidneys into highly sensitized patients who have few options left.
Frontiers Jun 10, 2026
Systematic review and meta-analysis of prediction models for diabetic kidney disease progression to ESRD
Diabetes & Endocrinology Meta-analysis
Systematic review and meta-analysis of prediction models for diabetic kidney disease progression to ESRD Kidney disease prediction models show promise but have major flaws
This meta-analysis of 15 studies evaluated prediction models for diabetic kidney disease progression to end-stage renal disease. Pooled AUCs…
Models that predict kidney failure in diabetic patients look accurate, but studies have serious problems that limit their use in real clinic…
Frontiers May 20, 2026
Meta-analysis finds lower bleeding risk with apixaban and rivaroxaban vs VKAs in dialysis patients with AF
Cardiology Meta-analysis
Meta-analysis finds lower bleeding risk with apixaban and rivaroxaban vs VKAs in dialysis patients with AF New Blood Thinners Cut Bleeding Risk For Dialysis Patients
This meta-analysis of observational studies and RCTs compared apixaban or rivaroxaban with vitamin K antagonists in dialysis patients with a…
New blood thinners could save lives for dialysis patients by cutting bleeding and stroke risks while waiting for bigger studies to confirm t…
May 14, 2026
Arterioarterial grafts show high patency in hemodialysis patients
Nephrology Meta-analysis
Arterioarterial grafts show high patency in hemodialysis patients Arterioarterial grafts show strong patency and low risks for hemodialysis patients with exhausted access sites
Meta-analysis of 514 hemodialysis patients found arterioarterial grafts maintain 92% primary patency at six months with low early complicati…
A review of 514 patients found arterioarterial grafts work well for those needing new dialysis access. Most grafts stayed open for years wit…
May 4, 2026
Meta-analysis shows associations between hypothyroidism and increased chronic kidney disease prevalence
Diabetes & Endocrinology Meta-analysis
Meta-analysis shows associations between hypothyroidism and increased chronic kidney disease prevalence Hypothyroidism Linked To Kidney Issues But Treatment Does Not Fix Them
This meta-analysis of 46 studies examines the relationship between hypothyroidism, including subclinical cases, and kidney outcomes.
Untreated low thyroid levels are strongly tied to worse kidney function in adults, but taking thyroid medicine does not seem to improve kidn…
Frontiers May 1, 2026
Machine learning model identifies RLS in ESRD patients with AUC 0.791
Neurology Cohort
Machine learning model identifies RLS in ESRD patients with AUC 0.791 Machine learning model helps identify restless legs in dialysis patients
This cohort study of 396 end-stage renal disease patients undergoing dialysis developed a machine learning classification model to identify …
A new machine learning model shows promise for spotting restless legs syndrome in people with end-stage kidney disease undergoing dialysis.
Frontiers Apr 29, 2026
Systematic review and meta-analysis shows exercise improves depression and quality of life in hemodialysis patients
Primary Care & Family Medicine Meta-analysis
Systematic review and meta-analysis shows exercise improves depression and quality of life in hemodialysis patients Exercise Cuts Depression in Dialysis Patients
This systematic review and meta-analysis evaluated exercise interventions in 1,597 maintenance hemodialysis patients.
It’s 3 a.m. Maria can’t sleep. Again. She’s exhausted, but her mind races with worry.
Frontiers Apr 23, 2026
Meta-analysis of nutrition education in adult dialysis patients shows improved knowledge and quality of life
Nephrology Meta-analysis
Meta-analysis of nutrition education in adult dialysis patients shows improved knowledge and quality of life Simple Diet Lessons Help Dialysis Patients Feel Better
This meta-analysis of trials in adult dialysis patients found that nutrition education interventions significantly improved knowledge and he…
Teaching patients about their food needs can improve how they feel and what they know.
Apr 22, 2026
Single-centre observational study on hemodialysis duration and outcomes in end-stage renal disease
Nephrology
Single-centre observational study on hemodialysis duration and outcomes in end-stage renal disease Shorter Dialysis Sessions May Offer Better Quality of Life for Older Patients
This observational study in 140 adults on hemodialysis compared less than 720 minutes per week to 720 minutes or more.
Shorter dialysis sessions may improve daily life for older patients without increasing their risk of death, offering a gentler approach to a…
medRxiv Apr 22, 2026
Total IgG Concentration Linked to Anemia in Hemodialysis Patients
Diabetes & Endocrinology Cohort
Total IgG Concentration Linked to Anemia in Hemodialysis Patients Is low immunity linked to anemia in dialysis patients, or just age?
This cross-sectional study included 351 participants, comprising 179 dialysis patients and 172 healthy controls.
Dialysis patients with weaker overall immune defenses are more likely to have anemia, while protection from chickenpox offers little clue ab…
Frontiers Apr 16, 2026
Cryopreserved venous allografts increased cold ischemia time in living-donor kidney transplant recipients
Orthopedics & Sports Medicine Cohort
Cryopreserved venous allografts increased cold ischemia time in living-donor kidney transplant recipients Does stretching a kidney vein during transplant add dangerous wait time for the organ?
This preliminary cohort study examined living-donor kidney transplant recipients and donors at two regional university hospitals.
Using cryopreserved veins to fix short donor kidney vessels adds nearly two hours to the organ's wait time before it reaches the recipient.
Frontiers Apr 16, 2026
Retrospective study identifies predictors for dialysis access steal syndrome in ESRD patients
Nephrology Cohort
Retrospective study identifies predictors for dialysis access steal syndrome in ESRD patients Study identifies factors that may predict dialysis access steal syndrome risk
A retrospective cohort study of 324 ESRD patients found 26.5% developed dialysis access steal syndrome (DASS).
A new model predicts dialysis access steal syndrome risk using patient frailty, body mass, and surgeon experience to help doctors spot dange…
Frontiers Apr 8, 2026

Questions about End Stage Renal Disease

Does symptom distress negatively affect quality of life in hemodialysis patients?

Yes, symptom distress — including post-dialysis fatigue, itching, anxiety, and depression — significantly reduces quality of life in hemodialysis patients.

Full answer →
How does nutrition education improve quality of life for adults with End Stage Renal Disease on dialysis?

Nutrition education significantly improves quality of life and dietary knowledge for adults on dialysis, according to a meta-analysis of 44 studies.

Full answer →

All End Stage Renal Disease Articles