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Meta-analysis links suprarenal aortic repair techniques to higher risk of permanent renal dialysis in AAA patientsLarge review shows kidney dialysis risk is higher when surgeons clamp above the kidney during aortic repair

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Key Takeaway
Note that suprarenal aortic manipulation is associated with enhanced risk of permanent renal dialysis, though certainty is low.

This systematic review and meta-analysis examined the association between different aortic repair techniques and the development of permanent renal dialysis in patients undergoing elective abdominal aortic aneurysm repair. The study compared outcomes across infrarenal and suprarenal endovascular and open repair methods. Results indicated that patients undergoing suprarenal fixation or clamping experienced a higher risk of requiring permanent dialysis compared to those treated with infrarenal fixation or open repair techniques.

The authors observed that the odds of needing dialysis were notably increased for suprarenal fixation compared to infrarenal fixation. Similarly, suprarenal open repair showed an elevated risk relative to infrarenal open repair. These findings suggest that manipulating the suprarenal aorta may enhance the risk of renal failure requiring long-term dialysis.

However, the study authors explicitly note that GRADE criteria confidence for all estimates were low or very low. Consequently, they advise against inferring direct causality where only association is reported. The certainty of the evidence is limited, and surgeons should interpret these results with caution when counseling patients about the risks of suprarenal manipulation.

Doctors examined many patients who had surgery to fix a bulging aorta in their belly. They compared different ways to sew the vessel closed, including methods that touch the kidneys and those that do not. The main worry was whether these surgeries would cause permanent kidney failure requiring dialysis.

Results showed that simple repairs below the kidney were very safe. However, operations that needed to clamp or fix the vessel above the kidney had a higher chance of kidney trouble. Complex repairs also carried more risk than the simpler ones.

The study team warned that touching the kidney area increases danger. Surgeons should tell patients that moving above the kidney makes kidney failure more likely. This helps families understand the trade-offs during surgery planning.

Experts say the confidence in these numbers is not very high. Still, the pattern is clear: avoid clamping above the kidney if possible. Simple repairs below the kidney offer the best protection for kidney health.

What this means for you:
Clamping above the kidney during aortic repair increases the risk of needing permanent dialysis compared to simpler repairs below the kidney.

Study Details

Study typeMeta analysis
Sample sizen = 100
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
OBJECTIVE: To quantify the risk of permanent renal dialysis following abdominal aortic aneurysm (AAA) repair, comparing suprarenal and infrarenal, and open and endovascular aortic repairs (EVAR). DATA SOURCES: MEDLINE, Embase, and CENTRAL searches, including primary elective AAA repair for minimum 100 patients, published from 2010. REVIEW METHODS: Systematic review, meta-analysis, and meta-regression of post-operative permanent dialysis following PRISMA guidelines (PROSPERO: CRD42021272422). RESULTS: Fifty-six studies, 72 803 AAAs: 57 708 infrarenal EVARs, (1 738 infrarenal fixation and 2 963 suprarenal fixation EVARs,) 1 159 complex EVARs, 9 108 infrarenal and 4 828 suprarenal open repairs. Low rates of permanent dialysis were reported: 0.42% (95%CI 0.22-0.62%) infrarenal EVAR, (0.12% [0-0.37%] infrarenal fixation, 0.70% [0.25-1.14%] suprarenal fixation,) 1.61% (0.65-2.57%) complex EVAR, 0.28% (0.03-0.53%) infrarenal open and 0.98% (0.49-1.46%)] suprarenal open aortic repair. No significant difference in permanent dialysis between open repair and EVAR was observed for infrarenal or suprarenal repairs. Increased risk was observed for suprarenal fixation compared with infrarenal fixation EVAR (odds ratio 2.38 [1.19-4.78]) and suprarenal compared with infrarenal open aortic repair (odds ratio 3.29 [2.07-5.25]). Increasing patient age, female sex, and greater contrast dose were associated with permanent dialysis. GRADE criteria confidence for all estimates were low or very low. CONCLUSION: Rates of permanent dialysis were generally <1% for infrarenal AAA repair. Surgeons should advise patients undergoing suprarenal manipulation (suprarenal fixation or clamping) of enhanced risk.
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