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Resistance training improves quality of life in Parkinson's disease, meta-analysis findsResistance training improves quality of life for Parkinson's disease

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Key Takeaway
Consider resistance training to improve quality of life in Parkinson's disease, but note limited evidence versus other therapies.

This meta-analysis evaluated the effect of resistance training on quality of life in people with Parkinson's disease. Compared to control groups, resistance training showed a significant improvement in quality of life (SMD -0.81, CI -1.45 to -0.18; I² 88%). However, no significant difference was found when compared to other therapeutic modalities (SMD -0.02, CI -0.44 to 0.41). The authors note high heterogeneity, data imputation for missing standard deviations, and underpowered exploratory subgroup analyses due to a limited number of trials. Safety was reported as a safe practice, though adverse events were not reported. The certainty of evidence is moderate for the comparison against control and low for the comparison against other modalities. Resistance training may improve quality of life, with potential trends favoring mild-to-moderate disease stages and interventions exceeding 12 weeks. Superiority over other modalities is not statistically significant, and subgroup analyses are exploratory.

How this fits prior evidence

This meta-analysis extends prior findings on Parkinson's disease interventions by focusing on resistance training. Previous coverage highlighted sex-specific genetic risk loci and causal proteins in Parkinson's disease, which may inform personalized exercise approaches. The current result aligns with the notion that non-pharmacological interventions can improve quality of life, though the high heterogeneity suggests that individual factors (e.g., disease stage, sex) may influence response, as seen in prior work on context-dependent modifiers.

Living with Parkinson's disease brings daily challenges that can impact how much joy and ease a person feels in their routine. New research looks at whether specific types of exercise, like resistance training, can help improve that overall sense of well-being.

The study found that people with Parkinson's who practiced resistance training reported a better quality of life than those in control groups. While the data showed no significant difference when comparing resistance training to other types of therapies, it did show a clear benefit over doing nothing at all. The results suggest that these workouts might be especially helpful for those in the mild to moderate stages of the disease, particularly when done for more than 12 weeks.

It is important to note that while the evidence for improvement over no exercise is solid, the data comparing it to other treatments is less certain because the studies were so different from one another. The study also noted that some smaller sub-groups were not large enough to draw firm conclusions. However, the overall findings suggest that resistance training is a safe and effective way to help patients feel better.

What this means for you:
Resistance training can improve quality of life for people with Parkinson's disease compared to no exercise.

Common questions

Can resistance training help my quality of life if I have Parkinson's?

Yes, the study found that resistance training was superior to a control group in improving quality of life for people with Parkinson's disease. The results suggest this may be especially helpful for those in mild to moderate stages who participate in programs lasting more than 12 weeks.

Is resistance training safe for people with Parkinson's?

The study reported resistance training as a safe practice for individuals with Parkinson's disease. No specific adverse events or serious safety concerns were noted in the data provided by the researchers.

Is resistance training better than other types of therapy?

The study did not find a significant difference when comparing resistance training to other therapeutic modalities. Because the studies involved were so different from each other, the certainty of this specific comparison is considered low.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
BACKGROUND: Parkinson's disease is a neurological condition with motor and non-motor symptoms that negatively affect well-being and quality of life. OBJECTIVE: This review aimed to analyze the effects of resistance training on quality of life in individuals with Parkinson's disease and to summarize recommendations for clinical application. DATA SOURCES: Following PRISMA recommendations, searches were conducted in Web of Science, PubMed, EMBASE (with ClinicalTrials.gov), PEDro, CINAHL, and Scopus. STUDY SELECTION: RCTs were included that compared the effects of resistance training with other therapeutic modalities or a control group on the quality of life in people with Parkinson's. DATA EXTRACTION AND SYNTHESIS: Data were extracted using Microsoft Excel and analyzed in RevMan. The risk of bias was assessed using the RoB 2 tool, the protocol reporting completeness was evaluated using CERT and certainty of the evidence was rated using GRADE. RESULTS: Fourteen studies were included, featuring highly heterogeneous protocols. Resistance training was superior to control (SMD -0.81; CI -1.45 to -0.18; I 88%; moderate certainty of the evidence), although no significant difference was found compared to other therapeutic modalities (SMD -0.02; CI -0.44 to 0.41; low certainty of the evidence). Exploratory subgroup analyses suggested a trend toward more favorable results in trials lasting longer than 12 weeks, involving patients with mild-to-moderate disease severity (H&Y ≤ 3), and reporting high protocol completeness (CERT > 11). Most of the studies were classified as having a low risk of bias and presented a moderate description of the protocols in the CERT. LIMITATIONS: The included studies exhibited high heterogeneity and required data imputation for missing standard deviations. Additionally, exploratory subgroup analyses were underpowered due to the limited number of trials. CONCLUSIONS: Current evidence suggests that resistance training may improve quality of life in individuals with Parkinson's disease. Exploratory subgroup analyses tentatively suggest potential trends favoring mild-to-moderate stages and intervention exceeding 12 weeks, while being a safe practice. However, high heterogeneity limits the certainty of the evidence. Future studies should prioritize standardized reporting (CERT) to ensure intervention reproducibility. TRIAL REGISTRATION: PROSPERO record (CRD42024588780).
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