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Respiratory muscle training improves respiratory muscle strength and pulmonary function in multiple sclerosis patientsA Simple Breathing Exercise May Strengthen a Core MS Symptom

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Key Takeaway
Consider RMT as an adjunctive therapy for targeted respiratory rehabilitation in multiple sclerosis, noting limited study numbers.

A systematic review and meta-analysis assessed the efficacy of respiratory muscle training (RMT) in individuals with multiple sclerosis. The analysis included 542 participants from a limited number of studies, comparing RMT against passive control, sham RMT, or usual care. No serious adverse events, discontinuations, or specific tolerability data were reported in the included studies.

Regarding respiratory outcomes, RMT significantly improved maximal inspiratory pressure (Hedges' g = 0.47), maximal expiratory pressure (Hedges' g = 0.28), forced expiratory volume in 1 second (Hedges' g = 0.39), and forced vital capacity (Hedges' g = 0.24). Additionally, a significant effect was observed for the SF-36 Physical Functioning subscale (Hedges' g = 0.40, 95% CI: 0.01 to 0.80). In contrast, the 6-minute walk distance (Hedges' g = 0.03) and the overall physical component summary of health-related quality of life (Hedges' g = 0.05) did not show significant improvement.

The primary limitation of this evidence is the small number of included studies, which restricts the precision of the estimates. While the data suggests RMT effectively improves respiratory muscle function, the lack of reported safety data and the limited study count mean these results should be interpreted with caution. RMT shows promise as an adjunctive therapy for targeted respiratory rehabilitation, providing a foundational evidence base to guide clinical practice and inform the design of future high-quality trials.

A Simple Breathing Exercise May Strengthen a Core MS Symptom

  • A new analysis shows targeted breathing training can improve lung strength and function in people with MS.
  • This could help manage a common but under-discussed symptom.
  • The training did not, however, improve overall walking endurance.

Why Breathing Becomes a Battle

MS is known for affecting mobility and balance. But its impact often goes deeper. The disease can disrupt the nerve signals to the muscles we use to breathe and cough.

This isn't about lung disease. It's about muscle weakness.

When the diaphragm and other respiratory muscles weaken, breathing becomes less efficient. People may feel constantly winded, have a weak cough, and tire easily. This steals energy for everything else.

Current MS care brilliantly manages the immune system and rehabilitation. Yet, direct respiratory muscle training (RMT) is rarely a standard part of the plan. This new research asks if that should change.

The Surprising Shift

The old way of thinking focused on general exercise and physical therapy for MS. Breathing problems were often seen as just another result of overall fatigue.

But here's the twist.

This analysis flips the script. It suggests we can target the breathing muscles themselves. By strengthening them directly, we may improve the mechanical act of breathing, regardless of other symptoms.

Think of it like targeted weightlifting for your diaphragm.

Respiratory muscle training is simple in concept. You use a small handheld device that provides resistance as you breathe in or out.

It’s like putting a tiny weight on your diaphragm.

When you breathe in against this resistance, your inspiratory muscles have to work harder. Over time, just like lifting weights builds biceps, this training builds stronger, more efficient breathing muscles. The goal is to make every breath you take throughout the day require less effort.

Researchers analyzed 16 high-quality studies involving over 540 people with MS. These studies tested various RMT programs, typically lasting 4 to 12 weeks, against control groups that did no training or used sham devices.

They measured concrete outcomes: lung strength, lung volume, how far people could walk in six minutes, and their reported quality of life.

The results were clear and promising. The meta-analysis found that respiratory muscle training significantly improved the two most important measures.

First, it made breathing muscles stronger. Second, it improved practical lung function—the amount of air people could move.

But here’s the catch.

While breathing got better, that improvement did not directly translate to better walking endurance in the tests. The average six-minute walk distance did not meaningfully increase.

However, there was a significant silver lining for daily life. People reported feeling better in a key area: their physical functioning. On a specific quality-of-life questionnaire, they noted real-world improvements in their ability to perform daily activities.

This doesn’t mean this treatment is available at your local clinic yet.

This kind of analysis is crucial. It pools data from many smaller studies to find a clear signal. It tells us that RMT has a direct and positive effect on the respiratory system in MS.

The fact that better breathing didn’t immediately improve walking distance is important. It suggests that walking endurance in MS is complex, tied to many factors like leg strength, balance, and fatigue. Improving one link in the chain doesn’t fix the whole system, but it strengthens a vital part.

If you or a loved one has MS and experiences shortness of breath or respiratory weakness, this research is a conversation starter.

Respiratory muscle training devices exist and are generally safe. However, they are not yet a standard, universally prescribed therapy for MS. This study provides strong evidence that could change that.

Do not buy a device online and start without guidance. The next step is to talk to your neurologist or a rehabilitation specialist (like a physiatrist or respiratory therapist). Ask if direct respiratory muscle training is appropriate for your specific situation and how to start a proper program.

This is an analysis of existing research, not a new clinical trial. The included studies were relatively small. Also, the training protocols (like how long and how intense) varied. More standardized, large-scale trials are needed.

This research provides a solid foundation. It clearly shows RMT improves respiratory strength and function. The next steps involve larger, longer-term trials to answer remaining questions.

Researchers need to find the optimal "dose" of training. They also want to see if improving breathing strength over a longer period eventually does help with endurance and prevents respiratory complications.

The path from research to standard practice takes time. But this analysis makes a compelling case that strengthening the breath could be a powerful new tool for living better with MS.

Study Details

Study typeMeta analysis
Sample sizen = 542
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the effects of respiratory muscle training (RMT) on respiratory function, exercise capacity, and health-related quality of life (HRQoL) in individuals with multiple sclerosis (MS). METHODS: A systematic search was conducted across eight electronic databases-Web of Science, PubMed (including MEDLINE and PubMed Central), SPORTDiscus, ScienceDirect, Scopus, Cochrane Library, Embase, and ProQuest-from their inception through September 22, 2025. Randomized controlled trials (RCTs) and quasi-RCTs that compared RMT with passive control, sham RMT, or usual care in individuals with MS were eligible for inclusion, with no restrictions on publication date. Eligible studies were required to report at least one of the following outcomes: respiratory muscle strength (e.g., maximal inspiratory pressure, MIP; maximal expiratory pressure, MEP), pulmonary function (e.g., forced expiratory volume in 1 s, FEV; forced vital capacity, FVC), functional exercise capacity (e.g., 6-minute walk distance, 6MWD), or HRQoL (e.g., SF-36, MSQOL-54). Two independent reviewers conducted the literature search and performed data extraction. The methodological quality and risk of bias of the included studies were assessed using the Cochrane Risk of Bias 2.0 tool (RoB2) and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework. RESULTS: A total of 16 studies involving 542 participants were included. The meta-analysis indicated that RMT significantly improved respiratory muscle strength (MIP: Hedges' g = 0.47; MEP: Hedges' g = 0.28) and pulmonary function (FEV: Hedges' g = 0.39; FVC: Hedges' g = 0.24). In contrast, RMT did not significantly improve functional exercise capacity (6MWD: Hedges' g = 0.03) or the overall physical component summary of HRQoL (Hedges' g = 0.05). A secondary analysis of a specific quality-of-life domain, however, showed a significant effect on the SF-36 Physical Functioning subscale (Hedges' g = 0.40, 95% CI: 0.01 to 0.80). CONCLUSION: RMT effectively improves respiratory muscle strength and pulmonary function in individuals with MS, and positively impacts specific Physical Functioning domains of HRQoL. However, current evidence does not support an improvement in functional exercise capacity. Despite the limited number of included studies, RMT shows promise as an adjunctive therapy for targeted respiratory rehabilitation. This study provides a foundational evidence base to guide clinical practice and inform the design of future high-quality trials.
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