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SAPIEN 3 TAVR shows similar outcomes to SAVR regardless of annular sizeTAVR valve procedure shows similar results to surgery for aortic stenosis

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Key Takeaway
Note that SAPIEN 3 TAVR results are comparable to SAVR across both small and large annulus sizes in low-risk patients.

This post hoc analysis of a randomized trial evaluated outcomes in 925 low-risk patients with severe, symptomatic aortic stenosis. The study compared TAVR using the balloon-expandable SAPIEN 3 valve against SAVR over a median follow-up of 5.2 years.

For the primary endpoint (death, stroke, or rehospitalization), results were similar between groups across both small and large annulus strata. In the small annulus group, TAVR showed an OR of 0.60 (21.2% vs 31.0%, 95% CI: 0.35-1.02). In the large annulus group, results were also similar (OR: 0.90; 23.5% vs 25.5%, 95% CI: 0.62-1.29).

Secondary outcomes included bioprosthetic valve failure and health status at 5 years. No effect modification by annular size was observed for either outcome (P for interaction = 0.22 for primary endpoint; P for interaction = 0.12 for health status).

Safety data regarding adverse events or tolerability were not reported. As a post hoc analysis, the findings should be interpreted with caution when determining clinical pathways. However, results suggest TAVR is comparable to SAVR regardless of annular size in this population.

How this fits prior evidence

How this fits prior evidence: This finding addresses a gap regarding the impact of anatomy on procedural choice by confirming that SAPIEN 3 TAVR outcomes are comparable to SAVR regardless of annular size. It complements previous coverage noting that early aortic valve intervention significantly reduces MACE compared to clinical surveillance in asymptomatic severe aortic stenosis.

Living with severe aortic stenosis means dealing with a narrowed heart valve that makes it harder for blood to flow. Doctors often have to choose between two main treatments: surgery (SAVR) or a less invasive procedure called TAVR, which uses a balloon-expandable SAPIEN 3 valve. A major question for patients is whether the size of their heart's opening, known as the annulus, changes which treatment is safer.

A follow-up analysis of a large study involving 925 low-risk patients looked at these outcomes over about five years. The results showed that both TAVR and surgery had similar rates of death, stroke, or rehospitalization. Importantly, the size of the patient's annulus did not change the outcome; both groups performed similarly regardless of their specific anatomy.

Other measures, like valve failure and overall health status at five years, were also similar between the two methods. While this was a post hoc analysis, meaning it looked back at existing data from a previous trial, it suggests that TAVR is a reliable option for these patients. You should talk to your doctor to see which path fits your specific needs.

What this means for you:
TAVR and surgical valve replacements show similar 5-year results regardless of the size of the heart's opening.

Common questions

Is the TAVR procedure safe for different heart sizes?

Yes. The study looked at 925 patients and found that TAVR using the SAPIEN 3 valve had similar results to surgery regardless of the size of the heart's opening (the annulus). There was no significant difference in death, stroke, or rehospitalization rates based on the size of the area.

How do TAVR and surgical outcomes compare over time?

Over a median of 5.2 years, both TAVR and surgery showed similar results. Patients in both groups had similar rates of valve failure and reported similar health status at the five-year mark, regardless of their specific heart anatomy.

What are the main risks for these procedures?

The study measured a primary outcome of death, stroke, or rehospitalization. Both TAVR and surgery showed similar rates for these events over five years. Because this was a post hoc analysis of existing data, you should speak with your doctor about specific risks for your case.

Study Details

Study typeRct
Sample sizen = 925
EvidenceLevel 2
Follow-up60.0 mo
PublishedJul 2026
View Original Abstract ↓
BACKGROUND: There are limited studies comparing the impact of transcatheter aortic valve replacement (TAVR) vs surgical aortic valve replacement (SAVR) by annular size. OBJECTIVES: The aim of this post hoc analysis from the PARTNER (Placement of Aortic Transcatheter Valves) 3 trial was to assess the relationship between annular size and outcomes among patients with severe aortic stenosis (AS) who underwent TAVR or SAVR. METHODS: Low-risk patients with severe, symptomatic AS were randomized to TAVR using the balloon-expandable SAPIEN 3 valve or SAVR. Patients were stratified by computed tomographic angiography-derived aortic annular area (small, ≤430 mm; large, >430 mm). The primary endpoint was the composite of death, stroke, or rehospitalization. Interactions among annular size, treatment strategy, and adjudicated 5-year clinical outcomes were assessed. RESULTS: Of the 925 patients with available computed tomographic angiography-derived annular size, 293 had small and 632 had large aortic annuli, respectively. Median follow-up duration was 5.2 years (Q1-Q3: 5.0-6.0 years). Five-year rates of the primary endpoint were similar for TAVR and SAVR in the overall cohort, results that were consistent for patients with small (21.2% vs 31.0%; OR: 0.60; 95% CI: 0.35-1.02) and large (23.5% vs 25.5%; OR: 0.90; 95% CI: 0.62-1.29) annuli, without effect modification by annular size (P for interaction = 0.22). Rates of bioprosthetic valve failure were similar and low at 5 years, without effect modification by annular size. Five-year health status was also similar between treatment modalities across annulus strata (P for interaction = 0.12). CONCLUSIONS: TAVR with the SAPIEN 3 valve led to similar 5-year clinical and health status outcomes compared with SAVR, irrespective of annular size. (PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis [P3]; NCT02675114).
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