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Home › Conditions › Aortic Stenosis

Aortic Stenosis

Part of Aortic Valve Disease

19 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Aortic Stenosis

34 trials tracked for Aortic Stenosis: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 122 citations.

34Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 2 Phase 2 1 Other / NA 29
  1. Phase 3 Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH Completed · 122 cited
  2. Phase 4 Acute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic Stenosis Completed · 73 cited
  3. Phase 4 Inflammation and Thrombosis in Patients With Severe Aortic Stenosis After Transcatheter Aortic Valve Replacement (TAVR) Completed
  4. Phase 3 An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis (Narrowing of the Major Blood Vessel of the Heart)(MK-0653A-043 AM4)(COMPLETED) Completed
  5. Phase 2 Intravenous Iron Supplement for Iron Deficiency in Patients With Severe Aortic Stenosis Completed
  6. N/A EDWARDS INTUITY Valve System CADENCE-MIS Study Completed
Show 28 more trials
  1. N/A EDWARDS INTUITY Valve System FOUNDATION Study Completed
  2. N/A Safety and Efficacy Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement Completed
  3. N/A Portico and Navitor India Clinical Trial Completed
  4. N/A The Medtronic CoreValve™ Evolut R™ CE Mark Clinical Study Completed
  5. N/A Association of Type of Anesthetic and Outcomes in Transfemoral Aortic Valve Replacement Completed
  6. N/A PERIGON Japan Trial Completed
  7. N/A China S3: Safety and Effectiveness of Edwards Lifesciences SAPIEN 3 THV in the Chinese Population Completed
  8. N/A CONFIDENCE Registry to Assess Safety and Performance of Portico System to Treat Patients With Severe Aortic Stenosis. Completed
  9. N/A ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE) Completed
  10. N/A CoreValve Advance International Post Market Study Completed
  11. N/A EDWARDS INTUITY Elite Valve System Completed
  12. N/A DEFLECT I: Keystone Heart Embolic Deflection Trial Completed
  13. N/A ADVANCE Direct Aortic Study Completed
  14. N/A Portico Valve-in-Valve Retrospective Registry Completed
  15. N/A Self-Centering Guide Catheter Feasibility Study Completed
  16. N/A PARTNER II Trial: S3iCAP Completed
  17. N/A Medtronic CoreValve Evolut R U.S. Clinical Study Completed
  18. N/A COronary and MICrocirculatory Measurements in Patients With Aortic Valve Stenosis. Completed
  19. N/A Safety and Efficacy Continued Access Study of the Medtronic CoreValve® System in the Treatment of Symptomatic Severe Aortic Stenosis in Very High Risk Subjects and High Risk Subjects Who Need Aortic Valve Replacement Completed
  20. N/A Correlation of Auscultatory Severity of Aortic Stenosis With Trans Thoracic Echocardiography Completed
  21. N/A Neuroprotection in Patients Undergoing Aortic Valve Replacement Completed
  22. N/A EDWARDS INTUITY Valve System CADENCE Study Completed
  23. N/A SAPIEN 3 Ultra EU PMS Completed
  24. N/A The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose Completed
  25. N/A Microembolic Signals and Cerebrospinal Fluid Markers of Neuronal Damage After Surgical Aortic Valve Replacement Completed
  26. N/A The ShortCut™ Continued Access Study Protocol Completed
  27. N/A PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - Nested Registry 3/Valve-in-Valve Completed
  28. N/A China XT: Safety and Effectiveness of Edwards Lifesciences SAPIEN XT THV in the Chinese Population Completed

Showing the 34 most-cited and recently-updated of 34 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Aortic Stenosis: what the trials found

Transcatheter Aortic Valve Replacement (TAVR) is associated with low rates of all-cause mortality (3% vs. 0%), cardiovascular mortality (2% vs. 0%), and stroke (0% vs. 0%) at 30 days post-procedure 2. Transcatheter Aortic Valve Replacement was also evaluated in a separate cohort 10.

Sildenafil treatment resulted in a -25% change in mean pulmonary artery pressure, a -29% change in pulmonary vascular resistance, and a 4% increase in cardiac index 3.

The combination of ezetimibe and simvastatin was evaluated for cardiovascular outcomes; while no significant difference was found in major cardiovascular events (p=0.591) or aortic valve events (p=0.732), there was a statistically significant reduction in ischemic cardiovascular events (p=0.024) 6.

Bivalirudin showed no significant difference in major bleeding at 48 hours (p=0.2692) or net adverse clinical events (NACE) at 30 days (p=0.4967) compared to the comparator 5.

Recent results — preliminary, needs further review

  • Intravenous iron isomaltoside was associated with a KCCQ Overall Summary Score of 88 vs. 82 1.
  • Post-intervention measurements (SAVR/TAVI) showed a decrease in FFR (-0.0279) and IMR (-2.8150) at 6 months 8.
  • Transcatheter Aortic Valve Implantation (TAVI) was evaluated in a large cohort 9.
  • The Shortcut device was evaluated in a small cohort 7.

For the clinician treating this condition

  • TAVR is associated with low 30-day mortality and stroke rates 2.
  • Sildenafil demonstrates measurable improvements in pulmonary pressure and resistance 3.
  • Ezetimibe combined with simvastatin significantly reduces ischemic cardiovascular events compared to the control 6.

AI synthesis of 9 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
SAPIEN 3 TAVR shows similar outcomes to SAVR regardless of annular size
Neurology RCT
SAPIEN 3 TAVR shows similar outcomes to SAVR regardless of annular size TAVR valve procedure shows similar results to surgery for aortic stenosis
This post hoc analysis of a randomized trial involving 925 low-risk patients with severe symptomatic aortic stenosis found that SAPIEN 3 TAV…
A new look at heart valve data shows that TAVR and surgical procedures offer similar safety and health outcomes regardless of patient anatom…
Jul 29, 2026
Staged PCI reduces severe kidney injury risk after TAVR in aortic stenosis and CAD
Cardiology Meta-analysis
Staged PCI reduces severe kidney injury risk after TAVR in aortic stenosis and CAD Staged heart procedures may lower risk of severe kidney injury
This meta-analysis of 7,119 patients with aortic stenosis and coronary artery disease undergoing TAVR found that staged PCI did not signific…
A new look at heart surgery data suggests that spacing out certain procedures could protect kidneys from severe damage.
medRxiv Jul 22, 2026
General anesthesia increases in-hospital mortality risk (RR 1.99) and pneumonia incidence (RR 2.39) in TAVI procedures
Cardiology Meta-analysis
General anesthesia increases in-hospital mortality risk (RR 1.99) and pneumonia incidence (RR 2.39) in TAVI procedures General anesthesia may increase risks for patients with aortic stenosis
This meta-analysis of 23,848 patients evaluates the impact of general anesthesia versus non-general anesthesia during transcatheter aortic v…
Patients undergoing TAVI procedures may face higher risks of death and pneumonia when using general anesthesia instead of other sedation met…
Frontiers Jul 17, 2026
Machine learning models outperform traditional scoring systems for predicting post-TAVR mortality risk
Cardiology Meta-analysis
Machine learning models outperform traditional scoring systems for predicting post-TAVR mortality risk Machine Learning Models Show Better Accuracy for TAVR Mortality Risk
This meta-analysis of 36 studies involving 272,390 patients evaluated various prediction models for mortality after TAVR. Machine learning m…
New analysis suggests machine learning tools may provide more accurate predictions of survival risk after heart valve replacement than stand…
Frontiers Jul 15, 2026
AI research in aortic valve disease surges, focusing on diagnosis and risk stratification
Cardiology Sys. Review
AI research in aortic valve disease surges, focusing on diagnosis and risk stratification Artificial Intelligence Shows Growth in Aortic Valve Disease Research
This systematic review of 270 articles analyzes the growing role of artificial intelligence in aortic valve disease, particularly aortic ste…
New research highlights how artificial intelligence is becoming a major tool for diagnosing and predicting risks in aortic valve disease.
Frontiers Jul 10, 2026
Early aortic valve intervention significantly reduces MACE compared to clinical surveillance in asymptomatic severe aortic stenosis
Cardiology Meta-analysis
Early aortic valve intervention significantly reduces MACE compared to clinical surveillance in asymptomatic severe aortic stenosis Early valve surgery reduces major heart events for aortic stenosis
This systematic review and meta-analysis of 3,086 patients found that early aortic valve intervention (AVR) results in a significant reducti…
New data shows that early surgical intervention can significantly reduce major heart complications for people with severe aortic stenosis.
Frontiers Jul 5, 2026
Cusp-overlap technique reduces mortality and conduction disturbances in patients undergoing transcatheter aortic valve replacement
Cardiology Meta-analysis
Cusp-overlap technique reduces mortality and conduction disturbances in patients undergoing transcatheter aortic valve replacement New technique shows lower death rates for aortic valve surgery
This meta-analysis of clinical studies evaluates the cusp-overlap technique (COT) compared to a three-cusp coplanar approach in TAVR. The st…
A specific placement technique during heart valve replacement may reduce death rates and the need for permanent pacemakers in patients.
Frontiers Jul 3, 2026
TAVR associated with higher 10-year mortality compared to surgery in intermediate-risk aortic stenosis
Radiology & Imaging RCT
TAVR associated with higher 10-year mortality compared to surgery in intermediate-risk aortic stenosis Trial shows surgery may offer better long term survival for aortic stenosis
This randomized trial of 1,910 patients with severe symptomatic aortic stenosis at intermediate surgical risk found that TAVR was associated…
A 10-year follow up of patients with aortic stenosis suggests that surgical treatment may have higher survival rates than TAVR procedures.
Jun 22, 2026
Transcatheter aortic valve replacement shows comparable mortality to surgery in severe symptomatic aortic stenosis
Neurology RCT
Transcatheter aortic valve replacement shows comparable mortality to surgery in severe symptomatic aortic stenosis Trial compares TAVR and surgery for aortic stenosis
This trial compared transcatheter aortic valve replacement with surgical aortic valve replacement in patients with severe symptomatic aortic…
A large trial shows that while TAVR and surgery have similar survival rates, TAVR may lead to more frequent follow-up procedures over time.
Jun 17, 2026
Computational modeling may improve TAVR planning but clinical translation remains limited
Orthopedics & Sports Medicine Meta-analysis
Computational modeling may improve TAVR planning but clinical translation remains limited Computational modelling may help predict TAVR risks before surgery
This systematic review examines computational modeling derived from patient-specific imaging for TAVR planning versus CT-based anatomical as…
A systematic review suggests patient-specific imaging models could predict complications in TAVR procedures, though clinical validation is s…
Frontiers Jun 5, 2026
Meta-analysis shows PCI before TAVR reduces revascularization but increases bleeding risk in severe aortic stenosis patients with coronary artery disease
Cardiology Meta-analysis
Meta-analysis shows PCI before TAVR reduces revascularization but increases bleeding risk in severe aortic stenosis patients with coronary artery disease Routine PCI before TAVR doesn't save lives, increases bleeding
A meta-analysis of 1,156 patients found that performing PCI before TAVR did not lower mortality but significantly reduced the need for urgen…
For people with severe aortic stenosis and clogged arteries, routine angioplasty before valve replacement didn't reduce deaths but did raise…
medRxiv May 20, 2026
RAS inhibitor use after TAVI linked to lower mortality in severe aortic stenosis
Cardiology RCT
RAS inhibitor use after TAVI linked to lower mortality in severe aortic stenosis Common Heart Pill May Boost Survival After Valve Replacement
This systematic review and meta-analysis of observational data from 36,015 patients with severe aortic stenosis undergoing TAVI found that u…
A common class of blood pressure pills appears to help people live longer after minimally invasive heart valve replacement, but doctors stil…
medRxiv May 11, 2026

Research across Aortic Valve Disease

Related studies from across the Aortic Valve Disease family.

Cardio Heart Connect intervention aims to improve daily steps for patients post-TAVR procedure
Cardiology RCT
Cardio Heart Connect intervention aims to improve daily steps for patients post-TAVR procedure New trial plans to test fitness apps for heart patients
This protocol describes a randomized trial of 200 patients on a cardiac rehab waitlist following TAVR. The study evaluates the Cardio Heart …
A new trial will test if mobile fitness programs help people with aortic valve disease stay active while waiting for cardiac rehab.
medRxiv Jun 18, 2026
Argatroban switch stabilized clinical status in a patient with mechanical aortic valve and LVAD after HIT
Cardiology Sys. Review
Argatroban switch stabilized clinical status in a patient with mechanical aortic valve and LVAD after HIT Blood thinner switch stabilizes LVAD patient with rare clotting disorder
This case report describes the management of heparin-induced thrombocytopenia (HIT) in a patient with a mechanical aortic valve and left ven…
A patient with a mechanical heart valve and LVAD developed dangerous clots after heparin. Switching to argatroban stabilized their condition…
Frontiers Jun 11, 2026
UK Biobank guideline review links higher UMOD levels to lower aortic regurgitation progression risk
Cardiology Guideline
UK Biobank guideline review links higher UMOD levels to lower aortic regurgitation progression risk Higher UMOD levels linked to lower risk of needing aortic valve replacement surgery in patients with aortic regurgitation
This observational cohort study from the UK Biobank evaluates circulating UMOD levels as a biomarker for aortic regurgitation progression. A…
New data shows people with higher UMOD levels face a lower chance of needing aortic valve surgery. This finding helps doctors better underst…
Frontiers May 14, 2026
In adult aortic regurgitation surgery, LVEF 55–60% with enlargement linked to higher readmission risk
Cardiology Cohort
In adult aortic regurgitation surgery, LVEF 55–60% with enlargement linked to higher readmission risk Heart Valve Surgery: Why Some Patients Return Sooner
This single-center retrospective cohort study included 841 adult patients with aortic regurgitation undergoing surgical treatment.
Heart valve surgery patients with slightly lower pumping power and enlarged hearts face a much higher risk of needing hospital care again.
Frontiers Apr 21, 2026
Serial echocardiography in severe aortic regurgitation shows LVESD and FS changes predict risk
Cardiology Cohort
Serial echocardiography in severe aortic regurgitation shows LVESD and FS changes predict risk Does waiting for a specific heart measurement number actually keep you safe?
A retrospective analysis of 140 patients with severe aortic regurgitation undergoing serial echocardiographic follow-up found that small inc…
Waiting for a specific heart measurement to justify surgery may miss warning signs, as every millimeter of heart widening raises risk by 5% …
medRxiv Apr 14, 2026

Questions about Aortic Stenosis

Do RAS inhibitors reduce mortality in patients undergoing TAVR for aortic stenosis?

Yes, multiple large studies show that RAS inhibitors after TAVR are associated with lower all-cause and cardiovascular mortality.

Full answer →
Can early surgery reduce death risk for asymptomatic very severe aortic stenosis?

Yes, early surgery significantly reduces long-term death risk in asymptomatic very severe aortic stenosis, with a 90% lower risk of cardiovascular death over 10 years.

Full answer →

All Aortic Stenosis Articles