Computational modeling may improve TAVR planning but clinical translation remains limited
Computational modelling may help predict TAVR risks before surgery
This systematic review examines computational modeling derived from patient-specific imaging for TAVR planning versus CT-based anatomical as…
A systematic review suggests patient-specific imaging models could predict complications in TAVR procedures, though clinical validation is s…
Meta-analysis shows PCI before TAVR reduces revascularization but increases bleeding risk in severe aortic stenosis patients with coronary artery disease
Routine PCI before TAVR doesn't save lives, increases bleeding
A meta-analysis of 1,156 patients found that performing PCI before TAVR did not lower mortality but significantly reduced the need for urgen…
For people with severe aortic stenosis and clogged arteries, routine angioplasty before valve replacement didn't reduce deaths but did raise…
RAS inhibitor use after TAVI linked to lower mortality in severe aortic stenosis
Common Heart Pill May Boost Survival After Valve Replacement
This systematic review and meta-analysis of observational data from 36,015 patients with severe aortic stenosis undergoing TAVI found that u…
A common class of blood pressure pills appears to help people live longer after minimally invasive heart valve replacement, but doctors stil…
Systematic review and meta-analysis evaluates apical sparing ratio for cardiac amyloidosis detection in hypertrophy
A specific heart pattern helps spot amyloidosis but misses some cases
This systematic review and meta-analysis evaluates the diagnostic accuracy of the apical sparing ratio (ASR) derived from echocardiographic …
A new analysis shows a heart scan pattern finds amyloidosis in most people with thick heart walls, but it still misses some cases.
PCI Reduces MACE in Nonfrail Patients With CAD and Severe Aortic Stenosis Undergoing TAVR
PCI reduces heart events in nonfrail patients but increases bleeding risk for frail patients
This randomized controlled trial evaluated percutaneous coronary intervention versus conservative treatment in 407 patients with coronary ar…
Stents cut heart attacks for strong patients with blocked arteries and new valves, but frail patients face higher bleeding risks instead of …
Phase 2 trial tests single-dose IV iron isomaltoside in severe aortic stenosis with iron deficiency
Early study suggests iron treatment may help heart function in severe aortic stenosis patients
This Phase 2, double-blind, randomized, placebo-controlled trial tested a single intravenous dose of iron isomaltoside versus placebo in pat…
Treating iron deficiency may improve exercise capacity and reduce fatigue in people with severe aortic stenosis, according to early trial re…
Deep learning model predicts post-TAVR LVOTO in patients with severe aortic stenosis
An AI Spots a Hidden Heart Risk Before a Common Valve Procedure
This retrospective observational study evaluated 302 patients undergoing transcatheter aortic valve replacement for severe aortic stenosis.
A new AI tool can analyze a simple heart ultrasound to predict a risky complication after a common valve procedure, potentially making the s…
RAS Inhibitors After TAVR Associated With Reduced Mortality in Meta-Analysis of 36,000 Patients
Heart medication after TAVR valve procedure linked to lower death risk in analysis
A Bayesian meta-analysis of 12 observational studies in 35,988 patients undergoing TAVR for aortic stenosis found RAS inhibitor therapy was …
Taking certain heart medications after a TAVR valve procedure is linked to a lower risk of death and fewer hospitalizations for heart failur…
Afterload-adjusted strain associated with outcomes in mixed aortic valve disease
Heart imaging measure linked to risk in patients with mixed aortic valve disease
A retrospective observational study of 950 patients with moderate or greater aortic stenosis found lower afterload-adjusted strain was indep…
A specific heart imaging measurement predicts higher risk of death or hospitalization in patients with mixed aortic valve disease.
Early surgery reduces cardiovascular death risk in asymptomatic very severe aortic stenosis over 10 years
Should doctors operate before symptoms appear for a severe heart valve problem?
A 10-year RCT of 145 asymptomatic patients with very severe aortic stenosis found early surgery significantly reduced the composite of opera…
Waiting for symptoms in severe heart valve disease may double your risk of death, as early surgery saved lives in a new 10-year study.
Research across Aortic Valve Disease
Related studies from across the Aortic Valve Disease family.
Argatroban switch stabilized clinical status in a patient with mechanical aortic valve and LVAD after HIT
Blood thinner switch stabilizes LVAD patient with rare clotting disorder
This case report describes the management of heparin-induced thrombocytopenia (HIT) in a patient with a mechanical aortic valve and left ven…
A patient with a mechanical heart valve and LVAD developed dangerous clots after heparin. Switching to argatroban stabilized their condition…
UK Biobank guideline review links higher UMOD levels to lower aortic regurgitation progression risk
Higher UMOD levels linked to lower risk of needing aortic valve replacement surgery in patients with aortic regurgitation
This observational cohort study from the UK Biobank evaluates circulating UMOD levels as a biomarker for aortic regurgitation progression. A…
New data shows people with higher UMOD levels face a lower chance of needing aortic valve surgery. This finding helps doctors better underst…
In adult aortic regurgitation surgery, LVEF 55–60% with enlargement linked to higher readmission risk
Heart Valve Surgery: Why Some Patients Return Sooner
This single-center retrospective cohort study included 841 adult patients with aortic regurgitation undergoing surgical treatment.
Heart valve surgery patients with slightly lower pumping power and enlarged hearts face a much higher risk of needing hospital care again.
Serial echocardiography in severe aortic regurgitation shows LVESD and FS changes predict risk
Does waiting for a specific heart measurement number actually keep you safe?
A retrospective analysis of 140 patients with severe aortic regurgitation undergoing serial echocardiographic follow-up found that small inc…
Waiting for a specific heart measurement to justify surgery may miss warning signs, as every millimeter of heart widening raises risk by 5% …
Questions about Aortic Stenosis
Do RAS inhibitors reduce mortality in patients undergoing TAVR for aortic stenosis?
Yes, multiple large studies show that RAS inhibitors after TAVR are associated with lower all-cause and cardiovascular mortality.
Full answer →Can early surgery reduce death risk for asymptomatic very severe aortic stenosis?
Yes, early surgery significantly reduces long-term death risk in asymptomatic very severe aortic stenosis, with a 90% lower risk of cardiovascular death over 10 years.
Full answer →