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Cardiac CT detects thrombi in 6.2% of acute stroke patients, outperforming echocardiographyCardiac CT finds hidden clots in stroke patients

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Key Takeaway
Consider cardiac CT in acute stroke imaging to detect thrombi, but interpret outcome associations cautiously.

This meta-analysis pooled data from prospective observational cohorts involving 3,919 patients with acute ischemic stroke who underwent cardiac CT as part of the acute stroke imaging protocol. The primary outcome was the proportion of patients with a thrombus detected on cardiac CT, which was 6.2% (243 of 3,919 patients). Compared with transthoracic echocardiography, cardiac CT had a significantly higher yield for detecting thrombi (OR 7.4; 95% CI, 4.0-15.1; p < 0.001).

Additional scan time was modest, with a median of 6 minutes (IQR, 5-7) for ECG-gated CT and 13 seconds (IQR, 12-61) for non-ECG-gated CT. The additional radiation dose was 2.9 mSv (IQR, 1.6-4.1). These findings suggest that adding cardiac CT to the acute stroke protocol is feasible without substantial time or radiation burden.

Patients with a cardiac thrombus had worse 90-day outcomes compared to those without: mortality was 33% versus 15% (OR 1.6; 95% CI, 1.1-2.3), and median modified Rankin Scale scores were 3 versus 2 (OR 1.6; 95% CI, 1.2-2.0). Recurrent stroke rates were 5% versus 4% (OR 1.4; 95% CI, 0.7-2.5), a difference that was not statistically significant.

The authors note that these associations were derived from adjusted odds ratios in observational data, so causation cannot be established. Limitations were not reported in the source. Clinically, cardiac CT appears to be a feasible and higher-yield alternative to transthoracic echocardiography for detecting cardiac thrombi in acute stroke, but its impact on management and outcomes requires further study.

When someone has a stroke, doctors race to find the cause. Sometimes the culprit is a blood clot hiding in the heart. A new analysis suggests that adding a quick heart CT scan to the usual stroke imaging could spot these clots more often than the standard ultrasound test.

The researchers pooled data from studies involving 3,919 people who had an acute ischemic stroke, meaning a stroke caused by a blocked blood vessel in the brain. They found that a heart CT scan detected a clot in about 6% of these patients. That's 243 out of 3,919 people.

Compared to transthoracic echocardiography, which is an ultrasound of the heart, the CT scan was much more likely to find a clot. In fact, the odds were 7.4 times higher. The extra scan time was short: about 6 minutes for a detailed ECG-gated scan, or just 13 seconds for a simpler one. The extra radiation was small, about 2.9 mSv.

People who had a heart clot were more likely to die within 90 days (33% vs. 15%) and had worse disability scores. However, the rate of another stroke was similar (5% vs. 4%), which was not a statistically significant difference. This is an observational analysis, so it can't prove that the clot caused the worse outcomes, but the link is concerning.

This is promising news, but it's not a final answer. The studies were observational, not randomized trials. Still, for stroke teams, adding a heart CT to the initial imaging could be a quick way to find hidden dangers and guide treatment.

What this means for you:
A heart CT during stroke workup finds hidden clots in 6% of patients, more than ultrasound.

Common questions

What is a cardiac CT scan?

A cardiac CT scan is a special X-ray test that takes detailed pictures of your heart. It can help doctors see if there are blood clots inside the heart chambers. In this study, it was done as part of the initial imaging for people who had a stroke.

How does cardiac CT compare to echocardiography for finding clots?

In this analysis, cardiac CT was much more likely to find a heart clot than transthoracic echocardiography, which is an ultrasound of the heart. The odds were 7.4 times higher. That means for every clot found by ultrasound, CT found about 7 more.

Is the extra radiation from cardiac CT a concern?

The extra radiation dose from the cardiac CT was about 2.9 mSv, which is roughly the amount you'd get from a year of natural background radiation. It's a small additional risk, but doctors weigh that against the benefit of finding a dangerous clot.

What does having a heart clot mean for stroke recovery?

In this study, people with a heart clot had a higher chance of dying within 90 days (33% vs. 15%) and had worse disability scores. However, the rate of having another stroke was similar (5% vs. 4%), which was not a statistically significant difference. This is an association, not proof of cause.

Study Details

Study typeMeta analysis
Sample sizen = 3,919
EvidenceLevel 1
PublishedAug 2026
View Original Abstract ↓
BACKGROUND: Cardiac computed tomography (CT) acquired during the acute stroke imaging protocol is an emerging modality to detect cardiac thrombi. We determined its yield in patients with acute ischemic stroke. METHODS: We performed a 1-stage individual patient data meta-analysis of 4 prospective observational cohorts (AIS of HEARTS [Acute Ischemic Stroke of Heart-Related Embolic Sources Detected on Acute Cardiac CT Scans]), including patients with acute ischemic stroke who underwent ECG-gated or non-ECG-gated cardiac CT between May 2018 and June 2024. We excluded patients with transient ischemic attack or stroke mimics. The primary outcome was the proportion of patients with a thrombus on cardiac CT. Secondary outcomes were additional scan time, radiation dose, comparison with echocardiography, and 90-day outcomes. We performed logistic regression analyses to compare 90-day outcomes between patients with and without thrombus, adjusting for age, sex, history of atrial fibrillation, ischemic heart disease, chronic heart failure, stroke or transient ischemic attack, anticoagulant use, prestroke modified Rankin Scale score, National Institutes of Health Stroke Scale score, large vessel occlusions, and intravenous thrombolysis, as appropriate for each outcome. RESULTS: We included 3919 patients (median age, 74 [interquartile range (IQR), 63-82], 58% male, median National Institutes of Health Stroke Scale score 6 [IQR, 3-12]). Cardiac CT detected a thrombus in 243 (6.2%) patients. Among 1323 patients that underwent both cardiac CT and transthoracic echocardiography, cardiac CT had a higher yield than transthoracic echocardiography (odds ratio, 7.4 [95% CI, 4.0-15.1]; <0.001). Median additional scan time was 6 minutes (IQR, 5-7) for ECG-gated and 13 seconds (IQR, 12-61) for non-ECG-gated cardiac CT. Median additional radiation dose was 2.9 mSv (IQR, 1.6-4.1). Patients with thrombi had higher 90-day mortality (33% versus 15%, adjusted odds ratio, 1.6 [95% CI, 1.1-2.3]) and worse modified Rankin Scale scores (median modified Rankin Scale score 3 versus 2, adjusted odds ratio, 1.6 [95% CI, 1.2-2.0]), but similar recurrent stroke rates (5% versus 4%, adjusted odds ratio, 1.4 [95% CI, 0.7-2.5]). CONCLUSIONS: Implementing cardiac CT into the acute stroke imaging protocol is feasible, detects thrombi in ≈6% of patients, and has a higher yield than transthoracic echocardiography. Cardiac thrombi were associated with higher mortality, but not higher stroke recurrence. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT07165093.
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