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rTMS-integrated dual-task training showed robust effects on lower limb motor recovery in stroke survivors compared to single-task or dual-task walking groups.

rTMS-integrated dual-task training showed robust effects on lower limb motor recovery in stroke surv…
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Key Takeaway
Note that rTMS-integrated dual-task training showed robust motor recovery effects in stroke survivors, though safety and effect size data were not reported.

This randomized controlled trial investigated the efficacy of rTMS-integrated dual-task training in 150 stroke survivors. Participants were assigned to either the intervention group or comparator groups consisting of single-task walking and cognitive-motor dual-task walking. Assessments for lower limb motor recovery, gait, balance, biomechanical parameters, and hemodynamic responses in the supplementary motor area and premotor cortex were conducted at baseline, 1, 3, and 6 months post-intervention.

Analysis using a two-way repeated measures ANOVA revealed a highly robust group by time interaction regarding lower limb motor recovery. The study did not report specific effect sizes, absolute numbers for outcomes, or exact p-values beyond implying significance through the description of robustness. Secondary outcomes including gait, balance, and hemodynamic responses were also assessed but specific numerical results were not provided in the available data.

Safety and tolerability data, including adverse events, serious adverse events, discontinuations, and general tolerability, were not reported. Funding sources and potential conflicts of interest were also not disclosed. The study setting was not specified. While the findings suggest a potential benefit, the lack of reported effect sizes and safety data limits the immediate clinical applicability. The robustness of the interaction indicates a strong statistical signal, yet the absence of detailed metrics prevents precise quantification of the intervention's magnitude.

Study Details

Study typeRct
EvidenceLevel 2
PublishedApr 2026
View Original Abstract ↓
BackgroundStroke remains a leading cause of long-term disability worldwide, imposing a substantial burden on individuals and healthcare systems. The recovery of gait and balance is often hindered by cognitive-motor interference, necessitating effective rehabilitation strategies.ObjectivesWe aimed to evaluate the synergistic efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive-motor dual-task training on lower limb motor recovery in stroke survivors.MethodsA total of 150 stroke survivors were randomized into three groups: the single-task walking group (Group 1, n = 48), the cognitive-motor dual-task walking group (Group 2, n = 52), and the rTMS-integrated dual-task group (Group 3, n = 50). Clinical outcomes and biomechanical parameters were assessed across four timepoints (baseline, 1, 3, and 6 months post-intervention). Analysis of covariance (ANCOVA) was utilized to control for lesion characteristics. Functional near-infrared spectroscopy (fNIRS) was employed to monitor hemodynamic responses in the supplementary motor area (SMA) and premotor cortex (PMC) during dual-task walking.ResultsA two-way repeated measures ANOVA revealed a highly robust group × time interaction (p 
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