Wide excision in a 67-year-old man with scrotal Paget's disease showed no recurrence and satisfactory outcomes.

This study presents a case report and clinical analysis focusing on a 67-year-old man diagnosed with scrotal Paget's disease. The setting and specific publication type are noted as a systematic review context, though the core evidence derives from this single patient case. The primary intervention involved wide excision of the lesion, with regular follow-up conducted until no signs of recurrence were observed. Diagnostic strategies included histopathological evaluation, which demonstrated positivity for cytokeratin 7 (CK7), gross cystic disease fluid protein-15 (GCDFP-15), and podoplanin (D2-40). Frozen section analysis was also performed, revealing positive margins at the 1, 2, 6, and 11 o'clock positions.

The main results indicate satisfactory treatment outcomes for this patient. Specifically, no signs of recurrence were observed at the most recent follow-up point. The study also addresses prognosis management and diagnostic strategies as secondary outcomes. Safety and tolerability were not explicitly detailed with adverse event data in the provided evidence, and no serious adverse events or discontinuations were reported. The study design is limited by the inclusion of only one patient, which inherently restricts the statistical power and ability to draw broad conclusions.

Key limitations include the small sample size of one patient and the lack of reported funding or conflicts of interest. The practice relevance is that this case provides a valuable practical reference for the standardized diagnosis and treatment of this rare condition. However, clinicians should note that the positive margins found on frozen section analysis may influence surgical planning in similar cases. The evidence does not support causal claims due to the observational nature of the case report.