Laughter yoga reduced fatigue in people with multiple sclerosis in a randomized controlled trial
This randomized controlled trial evaluated laughter yoga in 42 people with multiple sclerosis. The intervention group attended 12 sessions of laughter yoga, while the control group received standard care. The study setting was not reported, and funding or conflicts of interest were not reported.
Primary outcomes focused on fatigue severity. Fatigue decreased substantially in the intervention group, whereas no meaningful change was observed in the control group. The effect size for fatigue was a Cohen's d of 2.785. Secondary outcomes included sleep quality and psychological well-being. Sleep quality improved in the intervention group with a Cohen's d of 2.921 and a p-value less than 0.001. Psychological well-being increased within the intervention group, but the between-group effect at post-test was small with a Cohen's d of 0.485.
Safety data were not reported, and there were no reported adverse events, serious adverse events, discontinuations, or specific tolerability metrics. The study authors note that studies with larger samples are needed for generalizability. This low-cost and effective complementary psycho-social intervention can be used in clinical settings within the scope of nursing practice.