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Thrombectomy improved functional independence but increased hemorrhage risk in moderate-to-severe acute ischemic stroke patientsDoctors in China found surgery helped many stroke patients recover better function at home after ninety days

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Key Takeaway
Consider thrombectomy for moderate-to-severe stroke; improves independence but increases hemorrhage risk.

This open-label randomized trial with blinded outcome assessment investigated the effects of thrombectomy combined with medical management compared to medical management alone in adults presenting within 24 hours after moderate-to-severe acute ischemic stroke or medium-vessel occlusion. The study population included patients with a National Institutes of Health Stroke Scale score of 6 or higher.

The primary analysis focused on functional independence at 90 days, defined as a modified Rankin scale score of 0, 1, or 2. Results indicated a greater likelihood of achieving this functional status in the thrombectomy group compared to the control group. Secondary outcomes included rates of symptomatic intracranial hemorrhage and 90-day mortality, with the thrombectomy group showing a higher incidence of hemorrhage.

The authors observed that a violation of the proportional-odds assumption precluded the use of shift analysis for the primary outcome. This limitation suggests caution when interpreting the magnitude of benefit for the modified Rankin scale score. Funding came from the National Natural Science Foundation of China and the Noncommunicable Chronic Diseases-National Science and Technology Major Project.

Clinicians should weigh the potential for improved functional independence against the increased risk of symptomatic intracranial hemorrhage when considering thrombectomy for this specific patient population. The findings apply to centers where such procedures are available and appropriate for moderate-to-severe cases.

Researchers at forty-eight centers in China studied two hundred eighty patients who had moderate to severe strokes. These adults arrived at the hospital within twenty-four hours of their symptoms starting. One group received surgery to remove the blockage plus standard medical care. The other group received only standard medical care without surgery. The doctors carefully checked the results without knowing which treatment each patient received.

At ninety days, fifty-eight point six percent of the surgery group were functionally independent. This means they could care for themselves at home. Only forty-six point six percent of the group that had no surgery reached this goal. The difference was clear and statistically important for patient recovery.

The surgery group did face a small increase in bleeding inside the brain. Four point seven percent of patients in the surgery group had this problem. Only two point two percent of patients in the medical care group had bleeding. Death rates were similar for both groups at one in nine patients.

The study team noted some statistical limits in their analysis. They funded this work through the National Natural Science Foundation of China. Overall, the results suggest surgery can help many patients but doctors must weigh the bleeding risk carefully.

What this means for you:
Surgery plus standard care helped more stroke patients recover independence, but it slightly increased the risk of brain bleeding.

Study Details

Study typeRct
Sample sizen = 280
EvidenceLevel 2
Follow-up852.0 mo
PublishedMay 2026
View Original Abstract ↓
BACKGROUND: Endovascular thrombectomy for acute ischemic stroke due to medium-vessel occlusion has had varying results across trials. Whether thrombectomy improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits is unclear. METHODS: We conducted an open-label, randomized trial with blinded outcome assessment at 48 centers in China. Eligible patients were adults who presented within 24 hours after the onset of a moderate-to-severe stroke (National Institutes of Health Stroke Scale [NIHSS] score, ≥6; scale, 0 to 42, with higher scores indicating greater neurologic deficits) due to occlusion of a medium vessel. Patients were assigned in a 1:1 ratio to thrombectomy plus medical management (thrombectomy group) or medical management alone (control group). The primary outcome was functional disability as measured by the shift in the modified Rankin scale score (scale, 0 [no disability] to 6 [death]) at 90 days. Violation of the proportional-odds assumption precluded the use of shift in the modified Rankin scale score, so as prespecified, functional independence (modified Rankin scale score of 0, 1, or 2) at 90 days was used as the primary outcome. Safety outcomes were symptomatic intracranial hemorrhage and 90-day mortality. RESULTS: Among 280 patients in the thrombectomy group and 283 in the control group, the median age was 71 years, the median NIHSS score was 10 (range, 3 to 36), and 42.8% were women; 36.6% received intravenous thrombolysis. Functional independence at 90 days was seen in 58.6% of the patients in the thrombectomy group and in 46.6% of those in the control group (adjusted rate ratio, 1.24; 95% confidence interval, 1.07 to 1.44; P = 0.004). The incidence of symptomatic intracranial hemorrhage was 4.7% in the thrombectomy group and 2.2% in the control group; 90-day mortality was 11.1% and 10.2%, respectively. CONCLUSIONS: Among patients with acute ischemic stroke due to medium-vessel occlusion and moderate-to-severe deficits, thrombectomy led to a greater likelihood of functional independence than medical management alone but also to a higher risk of symptomatic intracranial hemorrhage. (Funded by the National Natural Science Foundation of China and the Noncommunicable Chronic Diseases-National Science and Technology Major Project; ORIENTAL-MeVO ClinicalTrials.gov number, NCT06146790.).
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