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Systematic review and meta-analysis compares intermittent vs. continuous enteral nutrition in critical illnessFeeding ICU Patients: Why Continuous May Be Safer Than Intermittent

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Key Takeaway
Consider continuous enteral nutrition as the preferable strategy for most critically ill patients, given higher gastrointestinal risks with intermittent feeding.

This is a systematic review and meta-analysis of studies comparing intermittent enteral nutrition (IEN) to continuous enteral nutrition (CEN) in critically ill adults. The analysis included 1662 patients (816 IEN, 846 CEN) from intensive care unit settings.

The authors synthesized findings that IEN was associated with a significantly higher incidence of diarrhea (RR 1.56, 95% CI 1.23 to 1.98) and abdominal distension (RR 1.68, 95% CI 1.10 to 2.57) compared to CEN. IEN was also associated with a prolonged ICU length of stay (MD 0.91 days, 95% CI 0.41 to 1.41). In contrast, constipation was lower with IEN (RR 0.74, 95% CI 0.57 to 0.97). No significant differences were found for ICU mortality, vomiting, gastric retention, aspiration pneumonia, or achievement of nutritional goals.

The authors acknowledge limitations, including potential heterogeneity in patient populations and interventions across included studies. Subgroup analyses suggested effects were more pronounced in mechanically ventilated patients. The certainty of pooled effect sizes is noted, with low heterogeneity for some outcomes.

Practice relevance is restrained; the authors suggest CEN may be preferable for most patients, with individualized approaches considering patient-specific factors. The review does not report follow-up duration or serious adverse events.

Imagine you are in the hospital, too sick to eat on your own. Doctors need to feed you through a tube to help you heal. But how should they do it? Should they give you a steady stream of food all day, or larger amounts at set times?

This is a common question in intensive care units (ICUs) around the world. A new review of 22 studies helps answer it. The findings suggest that a steady, continuous flow of nutrition is often easier on the body.

Critically ill patients in the ICU often cannot eat by mouth. They rely on a feeding tube to get the nutrients their body needs to fight infection and recover. This is called enteral nutrition.

There are two main ways to deliver this nutrition. One is continuous feeding, where a slow, steady drip of liquid food flows into the stomach over 24 hours. The other is intermittent feeding, where larger amounts of food are given over a shorter time, similar to regular meals.

Doctors have long debated which method is better. Does one lead to fewer side effects? Does one help patients recover faster? This new research, published in Frontiers in Medicine, brings us closer to an answer.

The Surprising Shift

For years, some clinicians thought intermittent feeding might be more natural. It mimics how we eat normally. The idea was that giving the stomach a rest between feeds might improve tolerance.

But here’s the twist. The new analysis shows the opposite may be true for many patients. When researchers combined data from 22 randomized trials involving 1,662 critically ill adults, a clear pattern emerged.

Intermittent feeding was linked to more stomach problems.

Think of your stomach like a small pond. If you pour a bucket of water into it all at once, the water level rises quickly and can overflow. This can cause ripples and mess.

Continuous feeding is like a tiny, steady stream of water flowing into the pond. The level stays low and stable. There is no sudden rush.

This analogy helps explain the study’s findings. Giving larger, intermittent feeds can overwhelm the stomach’s capacity. This may lead to more bloating and diarrhea. A continuous drip, however, is gentler and easier for the body to handle.

Researchers from South Korea conducted a comprehensive search for high-quality studies. They looked at trials that compared intermittent and continuous feeding in adult ICU patients.

They combined the results from 22 trials, which included a total of 1,662 patients. The goal was to see which method led to better outcomes, focusing on side effects, length of stay in the ICU, and survival rates.

The results were striking. Compared to continuous feeding, intermittent feeding was linked to a 56% higher risk of diarrhea. It was also linked to a 68% higher risk of abdominal distension, which is uncomfortable bloating.

Patients on intermittent feeding also stayed in the ICU about one day longer on average.

But there was one upside. Intermittent feeding was linked to a lower risk of constipation. This makes sense, as larger feeds can sometimes get things moving.

The effects were most pronounced in patients on mechanical ventilators. For these patients, the risks of diarrhea and bloating were even higher with intermittent feeding. For patients not on a ventilator, the differences were not statistically significant.

This doesn’t mean intermittent feeding is bad for everyone.

The study authors note that while continuous feeding appears safer for most, a one-size-fits-all approach is not ideal. The choice should depend on the patient’s specific condition.

For example, a patient who is not on a ventilator and has a stable stomach might tolerate intermittent feeding well. But for a ventilated patient, the risks of stomach upset are higher. The goal is to provide nutrition with the fewest side effects.

If you or a loved one is in the ICU, this research provides useful information. It suggests that continuous feeding is generally the preferred method for critically ill patients, especially those on ventilators.

However, this is a decision for your medical team. They will consider your overall health, your digestive tolerance, and your specific needs. Do not make changes to your feeding plan on your own. Always talk to your doctor or dietitian.

This research is based on a review of existing studies. It shows a strong link between feeding method and stomach side effects. But it does not prove cause and effect.

More high-quality trials are needed to confirm these findings. Researchers also want to identify which specific patient groups might benefit most from intermittent feeding. For now, the evidence points toward continuous feeding as the gentler, safer option for most critically ill patients.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
BackgroundBoth intermittent enteral nutrition (IEN) and continuous enteral nutrition (CEN) are used to provide nutritional support to critically ill patients. However, their comparative effects on gastrointestinal tolerance and clinical outcomes remain uncertain.ObjectivesWe conducted an updated systematic review and meta-analysis of randomized controlled trials (RCTs) to compare the efficacy and safety of IEN versus CEN in critically ill patients.MethodsWe performed a comprehensive literature search of PubMed, Embase, Scopus, and the Cochrane Library from inception through December 10, 2025, to identify RCTs comparing IEN and CEN in critically ill adults. The primary outcome was all-cause mortality in the intensive care unit (ICU). Secondary outcomes included gastrointestinal complications, length of ICU stay, and achievement of nutritional goals. Pooled risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs) were calculated using random-effects or fixed-effects models as appropriate. Subgroup analyses were performed according to mechanical ventilation status.ResultsTwenty-two RCTs comprising 1,662 critically ill patients (IEN, n = 816; CEN, n = 846) were included. Compared with CEN, IEN was associated with a significantly higher incidence of diarrhea (RR 1.56, 95% CI 1.23 to 1.98, I2 = 19%) and abdominal distension (RR 1.68, 95% CI 1.10 to 2.57, I2 = 18%), as well as prolonged ICU length of stay (MD 0.91, 95% CI 0.41 to 1.41, I2 = 0%). Conversely, IEN was associated with a lower incidence of constipation (RR 0.74, 95% CI 0.57 to 0.97, I2 = 0%). These effects were more pronounced in mechanically ventilated patients, whereas no statistically significant differences were observed in non-ventilated patients. No significant differences were identified between the two strategies regarding ICU mortality, vomiting, gastric retention, aspiration pneumonia, or achievement of nutritional goals.ConclusionThis updated meta-analysis demonstrates that IEN is associated with increased rates of diarrhea and abdominal distension and prolonged ICU length of stay compared with CEN, particularly among mechanically ventilated patients. Although IEN reduces the incidence of constipation, CEN may be the preferable feeding strategy for most critically ill patients. Individualized approaches considering patient-specific factors and clinical context are warranted. Further high-quality trials are needed to identify patient subgroups who might benefit from IEN.Systematic review registrationhttps://osf.io/krs8v.
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