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Intrauterine platelet-rich plasma infusion shows improved outcomes for women with unexplained recurrent implantation failurePlatelet-Rich Plasma May Help Women with Implantation Failure

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Key Takeaway
Consider PRP as a promising adjunct for recurrent implantation failure despite low overall evidence quality.

This umbrella review evaluates the efficacy of intrauterine infusion of platelet-rich plasma (PRP) as a potential intervention for women experiencing unexplained recurrent implantation failure (RIF). The synthesis focuses on primary outcomes including implantation rate, and secondary outcomes such as clinical pregnancy rate and live birth rate.

The meta-analysis indicates that PRP treatment is associated with improvements in implantation rates, clinical pregnancy rates, and live birth rates. These findings suggest that PRP may serve as a promising adjunct therapy for patients struggling with RIF.

Significant limitations exist regarding the strength of these conclusions. The authors note that the overall quality of evidence is low, and the certainty of evidence was either low or not reported across the included studies. Furthermore, there is a potential overestimation of the true effect due to the low quality of evidence or lack of assessment. Clinical application should be approached with caution given these limitations.

How this fits prior evidence

This umbrella review extends findings regarding platelet-rich plasma (PRP) for recurrent implantation failure. It specifically addresses outcomes such as clinical pregnancy and live birth rates, similar to previous reports indicating that PRP infusion improves pregnancy rates in RIF but may increase preterm births. While this study confirms the potential of PRP as an adjunct therapy, it highlights a low quality of evidence and uncertain certainty levels compared to earlier findings.

Researchers looked at several studies involving women who experienced repeated issues getting pregnant, a condition known as unexplained recurrent implantation failure. They specifically examined the use of platelet-rich plasma (PRP) injected into the uterus as a potential extra treatment.

The review found that using PRP was linked to improvements in three key areas: the rate of embryo implantation, the rate of clinical pregnancies, and the rate of live births. These results suggest that the treatment could be a helpful addition for women struggling with these specific fertility challenges.

However, it is important to note that the quality of the evidence is currently low. Because many of the studies were small or lacked detailed data, the actual impact of the treatment is not fully certain. Patients should discuss these findings with their doctors to see if this option fits their specific medical needs.

What this means for you:
Platelet-rich plasma shows promise for improving pregnancy rates in some cases, but evidence quality remains low.

Common questions

What is the role of platelet-rich plasma in fertility?

Platelet-rich plasma (PRP) is being studied as a potential extra treatment for women with unexplained recurrent implantation failure. The review found that using this treatment was linked to improvements in embryo implantation, clinical pregnancy rates, and live birth rates.

Is the evidence for this treatment strong?

The current evidence is considered low quality. Because of the limited data available from the studies reviewed, it is not yet certain how much of an effect the treatment has. It is currently seen as a promising but early option.

Who specifically can benefit from this treatment?

This finding specifically concerns women who have experienced unexplained recurrent implantation failure (RIF). These are cases where embryos fail to implant in the uterus despite standard treatments. You should talk to your doctor about these results.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
Background/objectiveThe role of platelet-rich plasma (PRP) in assisted reproductive technology is being explored, particularly in cases of recurrent implantation failure (RIF). The objective of our study is to thoroughly synthesise and critically assess the available evidence from systematic reviews and meta-analyses regarding the use of PRP in women with unexplained RIF.MethodsA thorough web search was performed on Medline, PubMed, EMBASE, Web of Science, OVID, JBI Evidence Synthesis, the Cochrane Database of Systematic Reviews, DARE, and the PROSPERO register to identify systematic reviews addressing the research question. Systematic reviews were assessed based on their “explicit, reproducible methodology,” comprehensive search strategy, acceptable methods for assessing the validity of included studies, evaluation of the risk of bias, and assessment of the certainty of the evidence. The methodological quality was assessed with the AMSTAR tool comprising 11 items. Before compiling the results, a corrected covered area (CCA) metric was used to evaluate the degree of overlap. Data extraction included descriptive variables and details about the intervention and outcomes.ResultsA total of 15 systematic reviews of randomised controlled trials are included. The CCA matrix revealed very high overlap (42%). Although our study showed an improvement in implantation rate, clinical pregnancy rate, and live birth rate, the certainty of evidence was either low or not reported. Therefore, it is difficult to make recommendations based on these findings as the quality of evidence was low.DiscussionAlthough the qualitative review of these reviews has shown a beneficial effect of PRP in RIF, this result cannot be recommended with certainty, as Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) analysis was performed in only five of the 15 studies. Meta-analysis of the individual outcomes after extracting data from all studies also revealed an overall beneficial effect of PRP in terms of various outcomes, i.e., live birth rate, clinical pregnancy rate, and implantation. However, this may be an overestimation of the true effect due to the low quality of evidence or the quality of evidence not being assessed.ConclusionIntrauterine infusion of PRP appears to be a promising adjunct therapy for women with unexplained recurrent implantation failure; however, the overall quality of evidence remains low.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42024504453, PROSPERO CRD42024504453.
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