Acupuncture plus embryo transfer increases clinical pregnancy rates in recurrent implantation failure patients.

This systematic review and meta-analysis pooled data from randomized controlled trials involving 1,428 patients diagnosed with recurrent implantation failure. The primary comparison assessed the addition of acupuncture to standard embryo transfer protocols against embryo transfer alone. Secondary outcomes included endometrial receptivity and psychological status, though specific numerical results for these were not detailed in the provided data.

The primary outcome, clinical pregnancy rate, was significantly higher in the intervention group. The relative risk was 1.73 with a 95% confidence interval of 1.51 to 1.99. The p-value was less than 0.05, indicating statistical significance. Absolute numbers for the outcomes were not reported in the source data.

Safety and tolerability data were not reported for this meta-analysis; adverse events, serious adverse events, discontinuations, and general tolerability were not documented. The certainty of evidence was evaluated using the GRADE framework. However, the authors noted that comprehensive evidence regarding the multidimensional effects of acupuncture remains limited. Funding sources and potential conflicts of interest were not reported. While the practice relevance is suggested by the positive finding, the lack of reported safety data and the specific limitations of the included trials warrant cautious interpretation before changing standard practice.