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RJBC-APP did not significantly improve 12-month adjuvant treatment compliance in early-stage breast cancerMobile App Shows Potential for Improving Early Breast Cancer Treatment

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Key Takeaway
Note that RJBC-APP showed no significant impact on 12-month compliance but may benefit younger patients at 3 months.

This Phase III multicenter randomized trial enrolled 496 patients with early-stage breast cancer following multidisciplinary team (MDT) review to evaluate the impact of the RJBC-APP mobile health application on adjuvant treatment compliance.

The primary outcome was the 12-month adjuvant treatment compliance rate. The RJBC-APP group showed a rate of 85.5% (n=249) compared to 81.4% (n=247) in the standard clinical management group, which did not reach statistical significance (P=0.212).

Secondary outcomes provided more nuanced data. The treatment completion rate at 3 months was significantly higher in the RJBC-APP group (93.2%) than in the control group (87.0%, P=0.022). Additionally, a statistically significant interaction was observed for patients aged 50 years or younger, who showed a higher completion rate with the app (85.0%) compared to the control (78.2%, P=0.043). No significant difference was found in patients over 50 years old.

Safety data and tolerability were not reported. The study notes that results from subgroup analyses are hypothesis-generating and require further investigation. While the app did not improve overall 12-month compliance, it showed potential benefits for younger patients or during shorter follow-up periods.

How this fits prior evidence

How this fits prior evidence: This finding addresses a gap in digital health interventions for breast cancer management. While previous coverage noted that progestin-only subdermal implants are linked to 23% higher breast cancer risk in younger women, this study specifically evaluates the role of mobile applications in improving treatment adherence for those same patients. The results suggest that while the RJBC-APP did not significantly improve overall 12-month compliance, it may offer specific benefits for younger populations.

Researchers conducted a large trial to see if a mobile application called RJBC-APP could help patients with early-stage breast cancer follow their treatment plans. The study included nearly 500 women who were undergoing adjuvant therapy after their initial diagnosis.

The results showed that while the app did not significantly improve overall completion rates at the 12-month mark, it did show promise in specific areas. Specifically, patients under age 50 and those using the app during the first three months of treatment had higher completion rates compared to those receiving standard care.

Because these specific findings for younger patients are preliminary, they are currently considered hypothesis-generating. This means more research is needed to confirm if the app consistently helps different groups over longer periods. For now, the app shows potential as a supportive tool rather than a proven replacement for standard clinical management.

What this means for you:
A mobile app may improve treatment completion for younger patients or during the first 3 months of breast cancer care.

Common questions

Does the mobile app improve long-term treatment for all patients?

The study found that the RJBC-APP did not lead to a statistically significant increase in 12-month treatment compliance compared to standard care. While the app showed promise in certain groups, it did not show a clear overall benefit for everyone over the full year.

Who specifically might benefit from using this mobile application?

The study suggested potential benefits for patients under age 50 and those looking to improve completion rates during the first 3 months of treatment. However, these specific results are currently considered hypothesis-generating and need more study.

How did the app perform in the first three months of treatment?

Patients using the RJBC-APP had a 93.2% completion rate at the 3-month mark, which was higher than the 87.0% seen in the group receiving standard care. This indicates a potential benefit for early-stage adherence.

Study Details

Study typeRct
Sample sizen = 508
EvidenceLevel 2
Follow-up12.0 mo
PublishedAug 2026
View Original Abstract ↓
BACKGROUND: Multidisciplinary therapy (MDT) can improve early breast cancer outcome, while its treatment completion rate is critical. This study aimed to evaluate the association of a mobile health application (RJBC-APP) information on MDT and its treatment adherence, compared with standard clinical management. METHODS: The RJBC-APP study is a prospective, multicenter, randomized, phase 3 clinical trial that enrolled patients with early-stage breast cancer after MDT for adjuvant treatment. Eligible patients were randomized at a 1:1 ratio into two groups: the RJBC-APP group (the mobile-based App) and the control group. The primary endpoint was 12-month adjuvant treatment compliance rate. Secondary endpoints included treatment adherence rates at 3, 6, and 24 months. RESULTS: Between October 2023 and July 2024, a total of 508 patients were randomized, and 496 were included in the final analysis (249 [50.2%] in the RJBC-APP group and 247 [49.8%] in the control group). The 12-month treatment compliance rate was 85.5% (95% confidence interval [CI]: 81.1%-90.0%) in the RJBC-APP group and 81.4% (95% CI: 76.5%-86.3%) in the control group (P = 0.212). Exploratory subgroup analysis revealed that RJBC-APP usage was associated with a higher treatment completion rate in patients aged ≤50 years (85.0% vs. 78.2%), whereas no comparable effect in older patients (86.2% vs. 86.0%) (P for interaction = 0.043). Additionally, the RJBC-APP improved the 3-month treatment completion rate compared with control group (93.2% vs. 87.0%, P = 0.022). CONCLUSIONS: The RJBC-APP did not improve 12-month adjuvant therapy compliance rate for early-stage breast cancer patients receiving MDT. While exploratory subgroup analysis indicated a potential benefit of the RJBC-APP on compliance in younger patients or in the short-term period, these should be considered as hypothesis-generating and warrant further investigation. TRIAL REGISTRATION: cinicalTrials.gov Identifier: NCT05921331.
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