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Climate-related environmental factors are associated with increased risk of infections relevant to vertical transmissionClimate Factors May Influence Risks of Infections During Pregnancy

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Key Takeaway
Note that climate-related factors are associated with increased risk of infections relevant to vertical transmission.

This systematic review synthesized 6 studies to evaluate the impact of climate-related environmental exposures, including temperature, humidity, and drought-associated famine, on infections relevant to vertical transmission in pregnant women and neonates. The review focused on outcomes such as maternal GBS colonization, VZV transmission, and HIV prevalence.

Findings indicate that higher temperature and humidity are associated with increased maternal GBS colonization. Conversely, cooler and drier conditions were associated with increased VZV transmission or earlier serological acquisition. Additionally, drought-associated famine was linked to increased HIV prevalence in rural Malawi. These associations may be driven by pathogen-specific biological pathways or broader social disruption and deprivation.

The authors note substantial heterogeneity and state that the certainty of evidence is very low across all outcome groupings. Importantly, no study reported vertical transmission as a direct outcome, and there is insufficient evidence to determine the specific impact of climate change on vertical transmission. Clinical application is limited by these uncertainties.

How this fits prior evidence

This review addresses a gap regarding the environmental drivers of infections relevant to vertical transmission. It expands upon the known high GBS transmission in African populations by identifying specific climate factors, such as temperature and humidity, that correlate with increased maternal GBS colonization. While the review does not provide data on antimicrobial resistance or azithromycin use, it highlights how environmental stressors may influence the prevalence of pathogens like GBS, VZV, and HIV.

Researchers reviewed several studies to see how climate factors like temperature, humidity, and drought might affect infections that can pass from a pregnant person to their baby. The review looked at specific conditions including Group B Streptococcus, Varicella-zoster virus, and HIV.

The findings showed different links for different conditions. Higher temperature and humidity were linked to more Group B Streptococcus. Conversely, cooler or drier conditions were linked to more Varicella-zoster virus. In one specific region, drought-related famine was linked to higher HIV rates in pregnant women.

It is important to note that these results show links, not direct causes. The researchers found that the evidence is currently very weak and inconsistent. There is not enough data yet to know exactly how climate change impacts the transmission of these infections from mother to child. These findings are preliminary and do not change current medical practices.

What this means for you:
Climate factors show links to certain infections during pregnancy, but evidence is currently weak and limited.

Common questions

How does temperature affect pregnancy infections?

The review found that higher temperature and humidity were associated with increased colonization of Group B Streptococcus. However, cooler and drier conditions were associated with increased transmission or earlier acquisition of the Varicella-zoster virus. These findings are based on a small number of studies and the overall certainty of the evidence is very low.

Is there a link between drought and HIV in pregnant women?

In a specific study of rural Malawi, drought-associated famine was linked to an increased prevalence of HIV in pregnant women. This suggests that social disruptions and deprivation caused by climate events can impact health outcomes, though more research is needed to confirm these links.

Does this mean climate change causes infections in babies?

No, the study did not find that climate factors directly caused infections in babies. The researchers noted that there is currently insufficient evidence to determine the specific impact of climate change on vertical transmission. The results show associations, not certain causes.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
Climate change influences infectious disease dynamics and disrupts maternal and neonatal health services, both of which are pathways through which the risk of vertically transmissible infections may increase. We systematically reviewed evidence on the association between climate-related environmental exposures and infection-related outcomes relevant to vertical transmission in pregnant or intrapartum women, neonates, and infants. Screening, extraction, and risk-of-bias assessment were performed independently in duplicate. Owing to substantial heterogeneity, findings were synthesised narratively. GRADE scoring was used to assess certainty of evidence. Of 4,579 records identified, 42 full texts were reviewed and 6 studies included. Studies examined drought/famine, temperature, humidity, and climate zone in relation to HIV, group B streptococcus (GBS), varicella-zoster virus (VZV), and bacterial meningitis. No study reported vertical transmission as an outcome. Higher temperature and humidity were associated with increased maternal GBS colonisation. Three studies suggested cooler and/or drier conditions were associated with increased VZV transmission or earlier serological acquisition. One study found drought-associated famine was linked to increased HIV prevalence in pregnant women in rural Malawi. Certainty of evidence was very low across outcome groupings. This review found evidence suggesting climate-related exposures may be associated with infections relevant to vertical transmission through pathogen-specific biological pathways, broader social disruption, and deprivation. There is currently insufficient evidence to determine the impact of climate change on vertical transmission or related outcomes. Closing this gap should be a priority for research and climate adaptation in maternal and neonatal health. https://www.crd.york.ac.uk/PROSPERO/view/CRD420251124435, PROSPERO CRD420251124435.
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