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KYR intervention is non-inferior to conventional genetic counseling in breast cancer risk knowledgeOnline genetic counseling works as well as in-person for high-risk women

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Key Takeaway
Consider KYR as a non-inferior, patient-driven alternative to conventional genetic counseling for high-risk breast cancer patients.

This randomized trial enrolled 866 women at elevated risk for breast cancer to evaluate the Know Your Risk (KYR) intervention compared to conventional genetic counseling. The KYR intervention included online pre-test educational videos, direct access to genetic testing, and patient preference for post-test genetic counseling.

Primary outcomes focused on knowledge of cancer genetics. Knowledge scores increased from a baseline mean of 6.87 to 8.66 (SD=2.16) in the KYR group and 8.56 (SD=2.14) in the conventional counseling group. Secondary outcomes, including breast cancer risk perception, attitudes about genetic counseling and testing, and satisfaction with genetic counseling, showed non-inferiority of the KYR intervention compared to conventional counseling.

No adverse events or discontinuations were reported. The study suggests that the KYR intervention may make genetic counseling and testing more accessible and convenient for patients while maintaining comparable outcomes to traditional methods. However, specific p-values or confidence intervals for the primary outcome were not reported.

How this fits prior evidence

How this fits prior evidence: This finding addresses a gap in patient education and navigation for breast cancer risk assessment. While previous coverage has addressed pharmacological treatments like SYHX2011 and DHP107, as well as non-pharmacological interventions for fatigue and anxiety, this study provides evidence on the efficacy of digital and preference-based counseling models.

If you're at high risk for breast cancer, getting genetic counseling can be a big step. But what if you could do it from home? A new study suggests that an online approach works just as well as the standard in-person visit.

The trial involved 866 women who were at elevated risk for breast cancer. Some received the "Know Your Risk" (KYR) intervention, which included online educational videos, direct access to genetic testing, and a choice of how to get post-test counseling. Others went through conventional genetic counseling.

Both groups improved their knowledge of cancer genetics. The KYR group's knowledge score went from about 6.87 to 8.66 out of 12, while the conventional group went from a similar baseline to 8.56. The online method was also non-inferior in terms of risk perception accuracy, attitudes, and satisfaction.

This doesn't mean online counseling is better, but it's a solid alternative. It could make genetic counseling more accessible and convenient for women who might otherwise skip it. The study was a randomized trial, which gives it good evidence strength, but the results are limited to the specific online program tested.

What this means for you:
Online genetic counseling is a viable alternative to in-person sessions for women at high breast cancer risk.

Common questions

Is online genetic counseling as good as in-person counseling?

Yes, according to this study. The online Know Your Risk intervention was non-inferior to conventional genetic counseling for improving knowledge, risk perception accuracy, attitudes, and satisfaction. Both groups showed similar improvements in knowledge scores.

Who was included in this study?

The study included 866 women who were at elevated risk for breast cancer. They were randomly assigned to either the online Know Your Risk intervention or conventional genetic counseling.

What did the online intervention involve?

The Know Your Risk intervention included online pre-test educational videos, direct access to genetic testing, and the option to choose how to receive post-test genetic counseling. It was designed to be more convenient and patient-driven.

What were the main results of the study?

The online group's knowledge score increased from a baseline mean of 6.87 to 8.66 out of 12, while the conventional group went from a similar baseline to 8.56. The online method was also non-inferior for risk accuracy, attitudes, and satisfaction.

Study Details

Study typeRct
EvidenceLevel 2
PublishedJun 2026
View Original Abstract ↓
PURPOSE: To determine if the developed Know Your Risk (KYR) intervention is similar to conventional genetic counseling; we evaluated participants' knowledge of cancer genetics, breast cancer risk perception, attitudes about genetic counseling and testing, and satisfaction with genetic counseling. METHODS: Women (n = 866) who screened at elevated risk for breast cancer were randomized to the KYR intervention or conventional genetic counseling (2022-2024). The KYR intervention included a series of online pre-test educational videos, direct access to genetic testing, and patient preference for receiving post-test genetic counseling. Participants completed surveys at baseline and after genetic counseling and testing. Non-inferiority hypothesis testing compared the two participant groups. RESULTS: The mean knowledge score (range 0-12) increased in both study groups from a baseline mean of 6.87 (standard deviation (SD) = 2.46) to 8.66 (SD = 2.16) for the KYR intervention and 8.56 (SD = 2.14) for conventional counseling. Additionally, statistical analyses suggest the non-inferiority of the KYR intervention for participants' accuracy of their breast cancer risk, attitudes about genetic counseling and genetic testing, and satisfaction with genetic counseling compared to participants randomized to conventional genetic counseling. CONCLUSION: Findings support that the components included in the KYR intervention are non-inferior for cancer genetic knowledge, risk perception, genetic counseling and testing attitudes, and genetic counseling satisfaction among women who screen at elevated risk for breast cancer. By using the combination of components included in the KYR intervention, genetic counseling and genetic testing are more accessible, convenient, and patient-driven. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05325151.
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