Endoscopic mucosal resection confirms rare gastric plasmacytoma in 53-year-old manRare Gastric Plasmacytoma Diagnosed After Acid Reflux Workup

This is a case report of a 53-year-old man presenting with acid reflux and heartburn who was found to have a primary solitary gastric plasmacytoma after undergoing endoscopic mucosal resection (EMR). The diagnosis was confirmed through histopathology, immunohistochemistry, bone marrow aspiration, serum and urine free light chain assays, and PET-CT, ruling out multiple myeloma and other plasma cell disorders. The report highlights the role of EMR in obtaining tissue for definitive diagnosis of this rare extramedullary plasmacytoma.

The authors note that gastric plasmacytoma is an uncommon presentation of plasma cell neoplasms, and this case adds to the limited literature. Key limitations include the single-patient design, which precludes any conclusions about treatment efficacy or prognosis. Follow-up duration and long-term outcomes were not reported.

For clinicians, this report serves as a reminder to consider plasma cell tumors in the differential diagnosis of gastric lesions, especially when endoscopic findings are atypical. However, practice recommendations cannot be drawn from a single case. Further studies with larger cohorts are needed to establish diagnostic and management guidelines.