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Moxibustion and auricular acupressure significantly reduce cancer-related fatigue in lung cancer patientsMoxibustion and Ear Acupressure May Ease Cancer Fatigue

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Key Takeaway
Consider moxibustion or auricular acupressure as potential non-pharmacological options for managing lung cancer fatigue.

This network meta-analysis synthesized data from 32 RCTs to evaluate the efficacy of TCM-based non-pharmacological therapies, including moxibustion, auricular acupressure, and qigong, for managing cancer-related fatigue (CRF) in patients with lung cancer.

The analysis found that moxibustion was significantly more effective than usual care (SMD = -2.56; 95% CI = -3.60 to -1.51) and more effective than qigong (SMD = -2.12; 95% CI = -3.58 to -0.65). Additionally, auricular acupressure was significantly more effective than usual care (SMD = -1.82; 95% CI = -3.61 to -0.03). These findings suggest that moxibustion and auricular acupressure may be more promising than qigong for alleviating CRF.

A primary limitation of this synthesis is the considerable risk of bias across the included studies. Consequently, the clinical certainty of these findings is limited. Further high-quality, rigorously designed clinical trials are necessary to validate these results before these TCM-based therapies can be routinely integrated into clinical practice for lung cancer patients.

How this fits prior evidence

This finding extends evidence regarding non-pharmacological symptom management in lung cancer. While tailored physical activity programs have been shown to improve functional capacity and reduce symptoms in lung cancer patients, this meta-analysis specifically addresses the efficacy of TCM-based interventions like moxibustion and auricular acupressure for cancer-related fatigue. The results suggest these specific modalities may offer distinct benefits for fatigue management compared to qigong.

If you or someone you love has lung cancer, you know that crushing tiredness can be as hard to bear as the disease itself. It's called cancer-related fatigue, and it can make even simple tasks feel impossible. Now, a new review of 32 randomized trials suggests that two traditional Chinese medicine techniques might help. Moxibustion, which involves burning a small cone or stick of dried herbs near the skin, and auricular acupressure, which uses pressure on specific points in the ear, both beat usual care for reducing fatigue. Moxibustion also outperformed qigong, a gentle movement practice. The numbers show large improvements, but there's a big catch: the studies had a considerable risk of bias, meaning their results might be inflated. The review didn't report any side effects, so we don't know if these treatments are safe for everyone. And the authors say we need more rigorous trials before we can trust these findings. So while this is interesting, it's not a reason to ditch proven treatments. Talk to your doctor if you're curious about adding these approaches.

What this means for you:
Moxibustion and ear acupressure show promise for cancer fatigue, but the evidence is not yet strong.

Common questions

What is moxibustion and how does it work?

Moxibustion is a traditional Chinese medicine technique where a small cone or stick of dried herbs (usually mugwort) is burned near or on the skin. The heat is thought to stimulate healing. In this review, it significantly reduced cancer-related fatigue compared to usual care, with a large effect size. However, the studies had a high risk of bias, so the true effect is uncertain.

Is auricular acupressure safe for cancer patients?

The review did not report any side effects or safety information for auricular acupressure. That means we don't know if it's safe for everyone. It involves pressing on specific points in the ear, often with small seeds or magnets. Before trying it, talk to your doctor, especially if you have other health conditions or are on treatment.

How effective is moxibustion compared to qigong for fatigue?

In the review, moxibustion was significantly more effective than qigong for reducing cancer-related fatigue, with a large effect size. But again, the evidence is limited by risk of bias in the included studies. Qigong appeared less effective than moxibustion, but it may still have other benefits not measured here.

Should I ask my doctor about these treatments?

Yes, it's always best to talk to your doctor before trying any complementary therapy. They can help you weigh the potential benefits against the unknown risks, especially since this review didn't report safety data. Your doctor can also tell you if these treatments might interact with your current care.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
BACKGROUND: Fatigue is a prevalent symptom in lung cancer patients and adversely affects their health and quality of life. While some evidence suggests that Traditional Chinese Medicine (TCM)-based non-pharmacological therapies can effectively alleviate cancer-related fatigue (CRF), it remains unclear which therapy is most effective for managing CRF in this population. OBJECTIVE: To compare the effects of different TCM-based non-pharmacological therapies on reducing CRF in lung cancer patients. METHODS: We searched eight databases from their inception to 24 November 2025. Following literature screening, the quality of the included randomized controlled trials (RCTs) was assessed using the Cochrane Risk of Bias 2.0 tool. A network meta-analysis was conducted to evaluate the relative efficacy of the TCM-based non-pharmacological therapies. Statistical analyses were performed using STATA 18.0 software. RESULTS: A total of 32 RCTs involving eight TCM-based non-pharmacological therapies were included. The network meta-analysis results indicated that moxibustion (SMD = -2.56, 95% CI = -3.60 to -1.51) and auricular acupressure (SMD = -1.82, 95% CI = -3.61 to -0.03) were significantly more effective than usual care in improving CRF. Furthermore, moxibustion showed a significant advantage over qigong (SMD = -2.12, 95% CI = -3.58 to -0.65). CONCLUSION: Current evidence shows that moxibustion and auricular acupressure may be the most promising TCM-based non-pharmacological therapies for alleviating CRF in lung cancer patients, whereas qigong appears less effective. However, given the considerable risk of bias across the included studies, these conclusions require further validation through more rigorously designed, high-quality clinical trials.
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