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Exergaming shows favorable outcomes for mobility, balance, and fatigue in adults with cancerInteractive video games can help adults with cancer improve mobility

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Key Takeaway
Consider exergaming as a feasible adjunct to cancer rehabilitation for improving mobility and fatigue, not as a replacement for standard therapy.

This systematic review synthesized evidence from 19 distinct study cohorts to evaluate the impact of exergaming, which integrates physical exercise with interactive digital games, on various outcomes in adults with cancer. The review focused on physical activity, mobility, balance, upper-extremity function, fatigue, and psychological and quality-of-life outcomes.

The authors found favorable results for mobility, balance, upper-extremity function, fatigue, and selected psychological and quality-of-life outcomes. In contrast, findings regarding muscle strength, pain, body composition, and biological or physiological markers were reported as inconsistent. The review notes that exergaming is a feasible and acceptable adjunct to cancer rehabilitation, but it is not a replacement for conventional exercise or physiotherapy.

Several limitations were identified, including incomplete adverse-event reporting, a lack of standardized intervention protocols, and a lack of adequately powered randomized trials. The evidence is characterized as preliminary due to inconsistent outcome reporting and limited diversity in cancer populations. Clinical application should be cautious as the evidence for specific physiological markers and muscle strength is not robust.

How this fits prior evidence

This systematic review addresses a gap in rehabilitation modalities by evaluating exergaming as a feasible adjunct to cancer care. While not directly related to the mechanisms of hypoxia or immunonutrition, it addresses the need for diverse rehabilitation tools. It complements existing evidence on psychosocial interventions and palliative care by providing a specific digital-integrated physical activity option to potentially improve quality-of-life outcomes and fatigue in cancer patients.

Living with cancer often means dealing with physical hurdles like fatigue and limited mobility. For many patients, traditional exercise can feel repetitive or difficult to stick with. This is where exergaming comes in. Exergaming combines physical exercise with interactive digital games to make movement more engaging and enjoyable.

Researchers looked at 19 different groups of adults with cancer to see if these games could help. They found that exergaming showed positive results for several key areas, including physical activity, balance, and upper-body function. It also appeared to help with fatigue and improved some psychological and quality of life outcomes for the patients.

While the results for muscle strength and pain were inconsistent, the study suggests that exergaming is a practical and well-tolerated addition to cancer rehabilitation. However, it is not a replacement for standard physical therapy. Because the evidence is still preliminary and the studies varied in how they were set up, patients should talk to their doctors about how to safely add these games to their routine.

What this means for you:
Exergaming is a helpful way to improve mobility and reduce fatigue for cancer patients, but it should supplement standard care.

Common questions

What is exergaming and how does it help?

Exergaming is a type of exercise that combines physical movement with interactive digital games. For adults with cancer, it can be a helpful way to improve physical activity, balance, and upper-body function while also helping to manage fatigue and improve overall quality of life.

Is exergaming safe for people with cancer?

The study reported no serious adverse events among the groups that provided safety data. While it is a feasible and well-tolerated addition to cancer rehabilitation, it should be used alongside, not instead of, conventional exercise or professional physiotherapy.

Does exergaming help with pain or muscle strength?

The results for muscle strength and pain were inconsistent across the studies reviewed. Because the evidence is still preliminary and studies varied, you should talk to your doctor to see if this specific type of exercise is right for your goals.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
BackgroundExergaming, which integrates physical exercise with interactive digital games, has gained attention as a supportive approach in cancer rehabilitation. However, uncertainty remains regarding its effects across different phases of cancer care and its feasibility in clinical and home-based settings. This systematic review synthesized evidence on the feasibility, safety, and effects of exergaming interventions among adults with cancer, with particular attention to interventions delivered during active treatment and after treatment completion.MethodsPubMed, Web of Science, the Cochrane Library, Scopus, Embase, CINAHL, and SPORTDiscus were searched from inception to April 2025. Randomized and nonrandomized intervention studies evaluating exergaming among adults with cancer were included. Outcomes were synthesized narratively across physical, psychological, symptom-related, quality-of-life, biological or physiological, and feasibility domains.ResultsTwenty-five publications representing 19 distinct study cohorts met the inclusion criteria. Interventions varied substantially in platform, setting, duration, and training dose, most commonly lasting 4–16 weeks with 2–5 sessions per week. Reported recruitment rates ranged from 11.8% to 85.7%, adherence from 62% to 100%, and attrition from 0% to 47.4%. No serious intervention-related adverse events were reported among studies that provided safety data, although adverse-event reporting was incomplete. Favorable findings were reported for physical activity, mobility, balance, upper-extremity function, fatigue, and selected psychological and quality-of-life outcomes. In contrast, findings for muscle strength, pain, body composition, and biological or physiological markers were inconsistent.ConclusionsExergaming appears to be a feasible and acceptable adjunct to cancer rehabilitation, with potential benefits for selected physical, symptom-related, and psychosocial outcomes. However, the evidence remains preliminary, and exergaming should be considered an adjunct rather than a replacement for conventional exercise or physiotherapy. Adequately powered randomized trials using standardized intervention protocols, consistent outcome reporting, longer follow-up, and more diverse cancer populations are needed.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024530181, identifier CRD42024530181.
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