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Retrospective review of 230 Northwest Ohio colorectal cancer patients identified demographic, lifestyle, and molecular risk factors.

Retrospective review of 230 Northwest Ohio colorectal cancer patients identified demographic, lifest…
Photo by Navy Medicine / Unsplash
Key Takeaway
Note that this small, unadjusted retrospective review of 230 patients serves only as a hypothesis-generating tool for future regional studies.

This study utilized a retrospective chart review design involving 230 patients diagnosed with colorectal cancer within the Northwest Ohio region. The investigation sought to characterize the population by evaluating demographic, lifestyle, and molecular risk factors associated with the disease. No specific intervention or comparator was defined in this observational assessment, and the primary outcome metrics were not reported in the provided data.

The analysis yielded no specific numerical results for the primary outcomes or secondary endpoints beyond the categorization of risk factors. Consequently, no quantitative data regarding disease progression, survival rates, or treatment efficacy could be extracted from the input. Safety data, including adverse events, serious adverse events, discontinuations, and tolerability, were not reported in the source material.

Key limitations of this study include the small size of the early-onset cohort and the reliance on unadjusted analyses. These methodological constraints significantly limit the ability to draw definitive conclusions or generalize findings to broader populations. The study is explicitly characterized as a hypothesis-generating tool intended to inform future research within the region rather than establishing clinical guidelines.

Clinicians should recognize that this evidence does not support causal inferences or specific therapeutic recommendations. The absence of reported follow-up duration and specific outcome percentages further restricts the immediate practical relevance for patient management decisions.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
Colorectal cancer (CRC) is one of the most prevalent malignancies in the world and is the second leading cause of cancer mortality. Concerningly, CRC affecting patients aged 30–49 has been skyrocketing in recent decades, which has prompted adjustments to screening guidelines in the United States in 2023. With this single-center retrospective chart review, we evaluated 230 patients with CRC from the Northwest Ohio region with the goal of potentially identifying trends in demographic, lifestyle, and molecular risk factors in these patients. With this study, we believe that we have produced a data set that, while limited by a small early-onset cohort and unadjusted analyses, may be appropriate for use as a hypothesis-generating tool for future studies within the region in order to help direct further discussion regarding CRC in patients aged 30–49.
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