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Narrative Review Examines Stereotactic Radiotherapy Use in Cancer Patients With Brain Metastases

Narrative Review Examines Stereotactic Radiotherapy Use in Cancer Patients With Brain Metastases
Photo by Logan Voss / Unsplash
Key Takeaway
Note this narrative review discusses stereotactic radiotherapy for brain metastases without reporting specific outcome data.

This narrative review focuses on brain metastases within the cancer patient population. It specifically addresses the use of stereotactic radiotherapy as an intervention. The publication type is classified as a review rather than a primary trial or meta-analysis.

The authors synthesize information regarding the intervention. However, the input data does not list specific main results or pooled effect sizes. No sample size or follow-up duration is reported in the source material. Consequently, quantitative conclusions regarding efficacy or safety cannot be derived from this summary. The absence of numerical data limits the ability to assess statistical significance or clinical magnitude.

Safety data including adverse events and tolerability are not reported. The review does not specify a comparator or setting. Limitations acknowledged by the authors are not detailed in the provided text. Funding or conflicts of interest are also not reported. This lack of detail restricts the assessment of potential biases or safety profiles associated with the treatment.

Practice relevance is not reported. Clinicians should recognize the descriptive nature of this evidence. It serves as an overview rather than a definitive guide for decision-making without further primary data. Further investigation is required to establish robust clinical recommendations based on this narrative synthesis.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
The incidence of brain metastases in cancer patients is increasing due to improved survival from systemic therapies and advancements in diagnostic imaging. Radiotherapy remains a cornerstone in the management of brain metastases. Among the various techniques, stereotactic radiotherapy (SRT) is widely adopted in multidisciplinary treatment owing to its high precision, rapid dose fall-off, high rates of local control, and superior preservation of neurocognitive function. In recent years, significant progress has been made in several areas of SRT, including technological advancements in equipment and radiation quality, its combination with surgery (either pre- or post-operatively), integration with systemic therapy (such as targeted and immunotherapy), and the exploration of new indications (e.g., more than 4 brain metastases, small cell lung cancer). Furthermore, optimization of dose fractionation regimens—including fractionated SRT, low-dose radiotherapy, exploration of maximum tolerated doses, and individualized ultrafractionated adaptive radiotherapy—has been actively investigated. This review synthesizes the evidence from classical literature and recent clinical studies to outline the current landscape and future directions of SRT for brain metastases.
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