PD-1/PD-L1 inhibitors with SRS or FSRT achieve 87% one-year local control in brain metastases
Combining immunotherapy and radiation for brain metastases shows promise
This meta-analysis of 2587 patients with brain metastases evaluated the combination of PD-1/PD-L1 inhibitors with stereotactic radiosurgery …
A new analysis shows that combining specific immunotherapy drugs with radiation can help control brain tumors and manage side effects.
Single-fraction stereotactic radiosurgery shows marginally higher 6-month local control than hypofractionated stereotactic radiotherapy
Single-fraction radiation shows slight edge in controlling brain metastases
This meta-analysis of 589 patients and 649 resection cavities compares single-fraction stereotactic radiosurgery (SF-SRS) to hypofractionate…
A single dose of radiation may offer slightly better local control for brain tumors after surgery compared to multiple doses.
EGFR-TKI plus anti-angiogenic therapy shows HR 0.63 for overall survival in NSCLC with brain metastases
Combination therapies show promise for lung cancer with brain spread
This systematic review and network meta-analysis of 5432 patients with EGFR-mutated non-small cell lung cancer and brain metastases found th…
New data suggests that combining specific drugs can improve survival and slow cancer growth in patients with lung cancer that has spread to …
Symptomatic radiation necrosis occurs in 5.7% of intracranial brachytherapy patients
Brachytherapy for brain tumors: 5.7% risk of radiation necrosis
This meta-analysis of 3666 patients undergoing intracranial brachytherapy for glioma, brain metastases, or meningioma found a pooled inciden…
About 1 in 18 patients who get internal radiation for brain tumors develop symptomatic radiation necrosis, a new analysis finds.
WBRT yields median survival of 3.6 months in Nigerian brain metastases patients
Brain radiation extends life by 3.6 months in Nigerian patients
This systematic review of 142 patients with brain metastases in Nigeria found that whole brain radiotherapy (WBRT) was associated with a med…
Whole brain radiotherapy gave Nigerian breast cancer patients with brain metastases a median survival of 3.6 months. A new review reveals th…
ctDNA positivity linked to increased risk of brain metastases in advanced solid tumors
ctDNA in blood and spinal fluid predicts brain metastases risk
This systematic review and meta-analysis of 1763 patients with advanced solid tumors found that ctDNA positivity is associated with a signif…
A new analysis finds that tumor DNA in blood or spinal fluid can signal a higher risk of brain metastases and worse survival.
WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
Whole-brain radiation shows no clear survival benefit for thyroid cancer brain metastases
A systematic review and individual patient data meta-analysis of 247 patients with thyroid cancer brain metastases found whole-brain radiati…
Whole-brain radiation therapy showed no clear survival benefit for patients with thyroid cancer that spread to their brain.
Adding WBRT to SRS cuts brain metastasis recurrence but raises cognitive decline without survival gain
Adding whole-brain radiation to SRS lowers recurrence but does not extend life for brain metastases patients
This meta-analysis of 1,757 patients with brain metastases found that adding whole-brain radiotherapy (WBRT) to stereotactic radiosurgery (S…
Combining SRS with whole-brain radiation lowers tumor recurrence but does not improve survival compared to SRS alone for patients with brain…
Systematic review examines tumor microenvironment mechanisms in lung cancer brain metastases
New brain strategies target lung cancer before it spreads
This systematic review explores the complex mechanisms driving brain metastasis in patients with lung cancer.
Doctors are finding clever new ways to fight lung cancer that has spread to the brain without breaking the body's natural barriers
Narrative Review Examines Stereotactic Radiotherapy Use in Cancer Patients With Brain Metastases
More Brain Mets? This Radiation Advance Changes Everything
This narrative review examines the role of stereotactic radiotherapy in cancer patients with brain metastases.
Every year, more cancer patients face a terrifying diagnosis: brain metastases.
Retrospective observational study evaluates systemic therapy surveillance in brain metastases patients
Observational study examines MRI surveillance patterns in patients with active brain metastases
This retrospective observational study abstract examines surveillance practices in 33 patients with active brain metastases treated with sys…
Doctors monitoring brain metastasis patients with new drugs found no difference in tumor growth or radiation needs whether they followed gui…
Stereotactic radiation improves symptoms versus hippocampal-avoidance whole brain radiation in patients with 5 to 20 brain metastases
Targeted Brain Radiation Eases Symptoms More Than Full-Brain Treatment
This Phase 3 randomized clinical trial enrolled 196 patients with 5 to 20 brain metastases and no prior brain-directed radiation across four…
Targeted radiation for brain tumors preserves daily functioning and quality of life better than whole-brain treatment in cancer patients wit…
Research across Brain Metastasis
Related studies from across the Brain Metastasis family.
Histopathology and methylome profiling confirm metastatic recurrence 13 years after curative treatment for GEJA
A brain tumor appears 13 years after cancer treatment
This case report and literature review describes a patient with gastroesophageal junction adenocarcinoma who presented with a solitary brain…
A patient and doctors discovered a brain tumor over a decade after they had successfully treated her esophageal cancer.
Disitamab vedotin and camrelizumab achieved durable remission in a patient with metastatic gastric cancer
New treatment combination shows promise for gastric cancer with brain metastasis
This case report and literature review describes a single patient with HER2-low, MSS advanced gastric cancer and brain metastasis who achiev…
A new combination of radiation and targeted therapies may help patients with advanced gastric cancer and brain metastasis achieve long-term …
CAR T-cell therapies targeting specific antigens show potential for treating pediatric CNS tumors
New CAR T-cell therapies show promise for pediatric brain tumors
This narrative review synthesizes 18 studies, including preclinical and early-phase clinical trials, regarding CAR T-cell therapy for pediat…
CAR T-cell therapy is showing potential to shrink tumors and extend life in children with aggressive brain cancers like DIPG.
AI diagnostic tools show high accuracy but limited real-world validation in systematic review
Artificial intelligence shows high accuracy in detecting various medical conditions
This systematic review of 24 studies synthesizes evidence on AI and deep learning for disease detection across multiple imaging modalities. …
New analysis of 24 studies shows AI tools can reach over 90% accuracy in spotting everything from lung cancer to skin disorders.
NODI parameters ODI and V-ISO differentiate gliomas from brain metastases in contrast-enhancing regions
Brain scan technique helps tell gliomas from metastases
This meta-analysis evaluates the use of Neurite orientation dispersion and density imaging (NODDI) to distinguish gliomas from brain metasta…
A new imaging method may help doctors distinguish between gliomas and brain metastases without invasive biopsy.
Local brain therapies associated with reduced mortality in HNSCC patients with brain metastasis
Local brain treatments linked to modest survival gains in rare head and neck cancer cases
This retrospective cohort analysis evaluated 201 patients with head and neck squamous cell carcinoma and brain metastasis from three tertiar…
Local brain treatments linked to lower death risk for rare head and neck cancer patients who develop brain metastases, though most still die…
Outpatient rehab improves function in children with brain tumours, but long-term effects unclear
Rehabilitation may help children with brain tumours
This systematic review of 8 papers found that outpatient rehabilitation interventions significantly improve functional outcomes in children …
A review of eight studies suggests outpatient rehab can improve function and quality of life for young brain tumour patients, but long-term …
3D C-Vit model improves tumor grading accuracy in 340 pediatric brain tumor cases
New AI Tool Grades Pediatric Brain Tumors With 91% Accuracy
This retrospective cohort review evaluated a 3D C-Vit model against clinical and radiomics models in 340 pediatric brain tumor cases.
A new AI tool grades pediatric brain tumors with 91% accuracy, helping doctors plan treatment faster and more reliably.
Non-randomized trial of neuromodulation prehabilitation for brain tumor language networks
Small study tests brain stimulation and language training before brain tumor surgery
This is a non-randomized controlled trial in 26 patients with operable brain tumors.
Brain stimulation and language training before surgery reduced overlap between stimulation targets and language areas in patients with opera…
Review of SIMMA utility for paediatric tumour monitoring via cfDNA profiling and ecDNA detection
A Simple Blood Test May Catch Children's Cancer Relapse Months Early
This review evaluates the clinical utility of the SIMMA single-molecule sequencing approach for profiling circulating and cerebrospinal flui…
A single blood or spinal fluid draw can now map a child's tumor DNA at a level of detail that may warn doctors of relapse long before scans …
Review of non-invasive prehabilitation for neuro-oncology patients at Institut Guttmann in Barcelona
Brain Tumor Surgery Is Terrifying — What If You Could Prepare Your Mind First?
This primary trial review examines a non-invasive prehabilitation (PRH) program in 29 neuro-oncology patients at Institut Guttmann in Barcel…
A pre-surgery wellness program significantly reduced emotional distress and improved quality of life for adults facing brain tumor removal.
Neurosurgery patients with brain tumors show preoperative financial capacity deficits compared to healthy controls
Brain tumor surgery patients often struggle with financial tasks before and after the operation
This prospective observational study evaluated 21 patients with brain tumors and 21 age- and education-matched healthy controls.
Brain tumor surgery patients often struggle with financial tasks like reading bills, and many overestimate their ability to manage money.
Questions about Brain Metastases
What are the treatment options for patients with 5 to 20 brain metastases?
For patients with 5 to 20 brain metastases, stereotactic radiation targeting individual tumors is a primary option that often improves symptoms compared to whole-brain radiation, though systemic therapies and surgery may also be used depending on the cancer type.
Full answer →What is the role of stereotactic radiotherapy for cancer patients with brain metastases?
Stereotactic radiotherapy (SRT) is a precise treatment that controls tumors and protects brain function, serving as a standard option for patients with one to four brain metastases and increasingly for those with more.
Full answer →All Brain Metastases Articles
- PD-1/PD-L1 inhibitors with SRS or FSRT achieve 87% one-year local control in brain metastases
- Single-fraction stereotactic radiosurgery shows marginally higher 6-month local control than hypofractionated stereotactic radiotherapy
- EGFR-TKI plus anti-angiogenic therapy shows HR 0.63 for overall survival in NSCLC with brain metastases
- Symptomatic radiation necrosis occurs in 5.7% of intracranial brachytherapy patients
- WBRT yields median survival of 3.6 months in Nigerian brain metastases patients
- ctDNA positivity linked to increased risk of brain metastases in advanced solid tumors
- WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
- Adding WBRT to SRS cuts brain metastasis recurrence but raises cognitive decline without survival gain
- Systematic review examines tumor microenvironment mechanisms in lung cancer brain metastases
- Narrative Review Examines Stereotactic Radiotherapy Use in Cancer Patients With Brain Metastases
- Retrospective observational study evaluates systemic therapy surveillance in brain metastases patients
- Stereotactic radiation improves symptoms versus hippocampal-avoidance whole brain radiation in patients with 5 to 20 brain metastases
- First-line osimertinib shows high response rates in EGFR-mutated NSCLC with active brain metastases
- Hypofractionated stereotactic radiation therapy showed high local control in breast cancer brain metastases