ctDNA positivity linked to increased risk of brain metastases in advanced solid tumors
ctDNA in blood and spinal fluid predicts brain metastases risk
This systematic review and meta-analysis of 1763 patients with advanced solid tumors found that ctDNA positivity is associated with a signif…
A new analysis finds that tumor DNA in blood or spinal fluid can signal a higher risk of brain metastases and worse survival.
WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
Whole-brain radiation shows no clear survival benefit for thyroid cancer brain metastases
A systematic review and individual patient data meta-analysis of 247 patients with thyroid cancer brain metastases found whole-brain radiati…
Whole-brain radiation therapy showed no clear survival benefit for patients with thyroid cancer that spread to their brain.
Adding WBRT to SRS cuts brain metastasis recurrence but raises cognitive decline without survival gain
Adding whole-brain radiation to SRS lowers recurrence but does not extend life for brain metastases patients
This meta-analysis of 1,757 patients with brain metastases found that adding whole-brain radiotherapy (WBRT) to stereotactic radiosurgery (S…
Combining SRS with whole-brain radiation lowers tumor recurrence but does not improve survival compared to SRS alone for patients with brain…
Systematic review examines tumor microenvironment mechanisms in lung cancer brain metastases
New brain strategies target lung cancer before it spreads
This systematic review explores the complex mechanisms driving brain metastasis in patients with lung cancer.
Doctors are finding clever new ways to fight lung cancer that has spread to the brain without breaking the body's natural barriers
Narrative Review Examines Stereotactic Radiotherapy Use in Cancer Patients With Brain Metastases
More Brain Mets? This Radiation Advance Changes Everything
This narrative review examines the role of stereotactic radiotherapy in cancer patients with brain metastases.
Every year, more cancer patients face a terrifying diagnosis: brain metastases.
Retrospective observational study evaluates systemic therapy surveillance in brain metastases patients
Observational study examines MRI surveillance patterns in patients with active brain metastases
This retrospective observational study abstract examines surveillance practices in 33 patients with active brain metastases treated with sys…
Doctors monitoring brain metastasis patients with new drugs found no difference in tumor growth or radiation needs whether they followed gui…
Stereotactic radiation improves symptoms versus hippocampal-avoidance whole brain radiation in patients with 5 to 20 brain metastases
Targeted Brain Radiation Eases Symptoms More Than Full-Brain Treatment
This Phase 3 randomized clinical trial enrolled 196 patients with 5 to 20 brain metastases and no prior brain-directed radiation across four…
Targeted radiation for brain tumors preserves daily functioning and quality of life better than whole-brain treatment in cancer patients wit…
First-line osimertinib shows high response rates in EGFR-mutated NSCLC with active brain metastases
Untreated Brain Metastases Respond Well to Osimertinib
This single-arm phase II trial evaluated first-line osimertinib in 100 patients with EGFR-mutated non-small cell lung cancer, including thos…
Osimertinib, a lung cancer drug, effectively treats untreated brain metastases, with an 81.8% response rate for measurable brain spots in a …
Hypofractionated stereotactic radiation therapy showed high local control in breast cancer brain metastases
FSRT shows promising results for brain metastases in breast cancer patients
This prospective single-arm phase 2 trial evaluated fractionated stereotactic radiation therapy (FSRT) in 173 patients with breast cancer an…
Fractionated stereotactic radiation therapy kept brain cancer controlled in 88.6% of breast cancer patients after one year with no severe si…
Research across Brain Metastasis
Related studies from across the Brain Metastasis family.
NODI parameters ODI and V-ISO differentiate gliomas from brain metastases in contrast-enhancing regions
Brain scan technique helps tell gliomas from metastases
This meta-analysis evaluates the use of Neurite orientation dispersion and density imaging (NODDI) to distinguish gliomas from brain metasta…
A new imaging method may help doctors distinguish between gliomas and brain metastases without invasive biopsy.
Local brain therapies associated with reduced mortality in HNSCC patients with brain metastasis
Local brain treatments linked to modest survival gains in rare head and neck cancer cases
This retrospective cohort analysis evaluated 201 patients with head and neck squamous cell carcinoma and brain metastasis from three tertiar…
Local brain treatments linked to lower death risk for rare head and neck cancer patients who develop brain metastases, though most still die…
Outpatient rehab improves function in children with brain tumours, but long-term effects unclear
Rehabilitation may help children with brain tumours
This systematic review of 8 papers found that outpatient rehabilitation interventions significantly improve functional outcomes in children …
A review of eight studies suggests outpatient rehab can improve function and quality of life for young brain tumour patients, but long-term …
3D C-Vit model improves tumor grading accuracy in 340 pediatric brain tumor cases
New AI Tool Grades Pediatric Brain Tumors With 91% Accuracy
This retrospective cohort review evaluated a 3D C-Vit model against clinical and radiomics models in 340 pediatric brain tumor cases.
A new AI tool grades pediatric brain tumors with 91% accuracy, helping doctors plan treatment faster and more reliably.
Non-randomized trial of neuromodulation prehabilitation for brain tumor language networks
Small study tests brain stimulation and language training before brain tumor surgery
This is a non-randomized controlled trial in 26 patients with operable brain tumors.
Brain stimulation and language training before surgery reduced overlap between stimulation targets and language areas in patients with opera…
Review of SIMMA utility for paediatric tumour monitoring via cfDNA profiling and ecDNA detection
A Simple Blood Test May Catch Children's Cancer Relapse Months Early
This review evaluates the clinical utility of the SIMMA single-molecule sequencing approach for profiling circulating and cerebrospinal flui…
A single blood or spinal fluid draw can now map a child's tumor DNA at a level of detail that may warn doctors of relapse long before scans …
Review of non-invasive prehabilitation for neuro-oncology patients at Institut Guttmann in Barcelona
Brain Tumor Surgery Is Terrifying — What If You Could Prepare Your Mind First?
This primary trial review examines a non-invasive prehabilitation (PRH) program in 29 neuro-oncology patients at Institut Guttmann in Barcel…
A pre-surgery wellness program significantly reduced emotional distress and improved quality of life for adults facing brain tumor removal.
Neurosurgery patients with brain tumors show preoperative financial capacity deficits compared to healthy controls
Brain tumor surgery patients often struggle with financial tasks before and after the operation
This prospective observational study evaluated 21 patients with brain tumors and 21 age- and education-matched healthy controls.
Brain tumor surgery patients often struggle with financial tasks like reading bills, and many overestimate their ability to manage money.
Elevated neutrophil-to-lymphocyte ratio predicts brain metastasis risk in lung cancer patients
Could a simple blood test help find who is most at risk for brain metastasis from lung cancer?
This systematic review and meta-analysis evaluated three immune inflammatory markers in 3,643 participants with lung cancer.
A simple blood test showing high inflammation markers can predict who is most likely to develop brain metastasis from lung cancer.
EMILIN-1 shows dual tumor-suppressive and promoting roles in brain tumor biology review
Review explores dual role of EMILIN-1 protein in brain tumor biology
A systematic review of experimental data describes EMILIN-1's complex role in nervous system tumors.
A protein called EMILIN-1 might slow brain tumors in some ways but could also change the immune response to help them grow faster.
Hierarchical Barycentric Framework Shows Consistent Improvements in Brain Tumor MRI Analysis
New AI method shows consistent improvements in brain tumor MRI analysis tasks
A preprint computational study proposes a novel Hierarchical Barycentric Multimodal Representation Learning framework for medical imaging.
A new AI method consistently improves how medical images analyze brain tumors, offering a more robust way to handle missing data in scans.
Questions about Brain Metastases
What are the treatment options for patients with 5 to 20 brain metastases?
For patients with 5 to 20 brain metastases, stereotactic radiation targeting individual tumors is a primary option that often improves symptoms compared to whole-brain radiation, though systemic therapies and surgery may also be used depending on the cancer type.
Full answer →What is the role of stereotactic radiotherapy for cancer patients with brain metastases?
Stereotactic radiotherapy (SRT) is a precise treatment that controls tumors and protects brain function, serving as a standard option for patients with one to four brain metastases and increasingly for those with more.
Full answer →