This case report describes two patients who had inoperable anal Buschke–Löwenstein tumors. These are rare growths that cannot be removed with surgery. The doctors treated them with definitive radiotherapy using volumetric-modulated arc therapy. One patient also received concurrent chemoradiotherapy, while the other received radiotherapy alone.
Both patients showed a clinical response to the treatment. The first patient had a marked response, and the second had a partial response. The treatments were well tolerated. Patient 1 experienced grade 2 acute radiomucositis, which is a mild inflammation of the lining of the mouth or throat. Patient 2 had minimal toxicity. No serious adverse events were reported.
The authors note that evidence for radiotherapy as a primary treatment is limited. The literature review showed heterogeneous treatment approaches. This report supports considering radiotherapy in the multidisciplinary management of this rare condition. It is important to remember that these findings come from only two cases and should not be generalized to all patients.
