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Specific gut microbiota taxa are associated with the presence of diabetic retinopathy in T2DM patientsGut Bacteria Differences Linked to Diabetic Retinopathy in Diabetes Patients

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Key Takeaway
Note that specific gut microbiota taxa like Patescibacteria and Synergistetes are associated with a lower prevalence of DR.

This meta-analysis investigated the relationship between gut microbiota composition and diversity in individuals with Type 2 Diabetes Mellitus (T2DM) who also presented with Diabetic Retinopathy (DR). The analysis included a sample size of 486 patients.

The synthesis revealed that while no significant difference was observed in overall alpha-diversity between T2DM and DR patients, specific taxonomic differences were identified. Specifically, Patescibacteria and Synergistetes were significantly lower in DR patients compared to those with T2DM only. Conversely, Verrucomicrobia were considerably higher in DR patients, and Bacteroides showed an increase in the DR group.

The authors noted limitations including a small number of studies and relatively high heterogeneity among the included data. These factors contribute to uncertainty regarding the strength of these associations. Clinical application is currently limited as the study establishes only associations between gut microbiota changes and DR, without identifying specific mechanisms or confirming causality.

How this fits prior evidence

This finding addresses a gap in understanding the systemic components of diabetic complications. While prior evidence established that T2DM, ASCVD, HFpEF, MASLD, hypertension, and CKD share a single pathophysiological continuum, this meta-analysis explores the specific role of gut microbiota in the progression to retinopathy. It does not directly relate to the efficacy of AI-OCT for screening or deep learning models for identifying stages of diabetic retinopathy.

Researchers looked at the gut bacteria of 486 people with Type 2 diabetes. They compared patients who had diabetic retinopathy, a condition that can damage the eyes, to those who did not have it. The study aimed to see if different types of bacteria were associated with the progression of this eye disease.

The analysis found that while overall bacterial diversity was similar in both groups, specific types of bacteria differed significantly. Patients with diabetic retinopathy had lower levels of Patescibacteria and Synergistetes. They also showed higher levels of Verrucomicrobia and Bacteroides compared to those without the condition.

Because this study involved a small number of reports and showed high variation between studies, these results are not yet definitive. The findings show an association between gut health and eye disease but do not prove that changing the gut causes changes in the eyes. These results are early and may need more research to understand what these specific bacteria mean for patient care.

What this means for you:
Specific gut bacteria levels are linked to diabetic retinopathy, but more research is needed to confirm these links.

Common questions

What did the study find about gut bacteria and eye health?

The study found that while overall diversity was similar, specific groups of bacteria were different. Patients with diabetic retinopathy had lower levels of Patescibacteria and Synergistetes, but higher levels of Verrucomicrobia and Bacteroides compared to patients without the condition.

Is this a proven treatment for eye problems in diabetes?

No, this study only shows an association between gut bacteria and diabetic retinopathy. It does not prove that changing these bacteria treats or prevents eye damage. Because of the small number of studies and high variation, more research is needed before any clinical changes can be made.

Who was included in this study?

The study analyzed data from 486 individuals with Type 2 Diabetes Mellitus. This group included 258 patients with Type 2 Diabetes and 228 patients who had both Type 2 Diabetes and Diabetic Retinopathy.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
PURPOSE: The results of human observational studies on the correlation between gut microbiota and diabetic retinopathy (DR) are discrepant. This meta-analysis aimed to evaluate the specificity of the gut microbiota in DR patients compared to patients with type 2 diabetes mellitus (T2DM). METHODS: All published literature up to October 2024 was searched by two researchers on PubMed, Embase and Web of Science databases. Diversity and gut microbiota composition were the main outcomes. The meta-analysis was conducted in Review Manager (RevMan) Version 5.3. RESULTS: Eight studies, investigating gut microbiota by collecting stool samples, conducted in China and India were included in this meta-analysis, involving a total of 486 individuals in the T2DM (n = 258) and DR (n = 228) groups. No significant difference in alpha-diversity was observed between T2DM and DR patients. The pooled estimate showed that, at the phylum level, the abundances of Patescibacteria, and Synergistetes were significantly lower, and Verrucomicrobia were considerably higher in DR patients than in T2DM patients. At the genus level, DR patients had an increase in Bacteroides compared to T2DM. CONCLUSIONS: In this meta-analysis with a small number of studies and relatively high heterogeneity, changes in gut microbiota were associated with DR, commonly reflected by a reduction in beneficial species and an increase in pathogenic species influencing metabolic pathways.
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