Wavefront-guided LASIK and PRK show high rates of 20/20 vision in patients with myopia and astigmatism.

This prospective, nonrandomized clinical trial was conducted at an academic eye institute in Palo Alto, California. The study population consisted of 66 eyes from 33 patients undergoing WFG-LASIK and 71 eyes from 36 patients undergoing WFG-PRK. All patients had no history of refractive surgery and preoperative refractive errors with a sphere up to -10.25 D, a cylinder up to 4.50 D, and a maximum spherical equivalent of -10.00 D. Procedures were performed by cornea fellows in training. The primary outcome was UDVA at 3 months, with secondary outcomes including safety and predictability.

In the WFG-LASIK group, 91.2% of eyes achieved UDVA of 20/20 or better, while 35.3% achieved 20/15 or better. Manifest refraction spherical equivalent (MRSE) was within 0.50 D of target in 91.2% of eyes, with a mean SE of -0.04 D. In the WFG-PRK group, 82.0% of eyes achieved UDVA of 20/20 or better, and 10.0% achieved 20/15 or better. MRSE was within 0.50 D of target in 98.0% of eyes, with a mean SE of -0.01 D.

Safety data were not reported in detail, though no adverse or serious adverse events were noted. The study design was prospective but nonrandomized, which limits the ability to draw causal conclusions regarding the superiority of one procedure over another. Additionally, the lack of a control group or direct comparator within the study design restricts the generalizability of these results to broader clinical practice.

These results indicate high predictability for wavefront-guided procedures in this specific population, but the observational nature of the trial and the absence of detailed safety reporting necessitate cautious application of these findings in clinical decision-making.