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Preoperative tranexamic acid did not reduce transfusion rates in geriatric patients with hip fracturesTrial shows tranexamic acid does not reduce hip fracture transfusions

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Key Takeaway
Note that preoperative tranexamic acid did not reduce transfusion rates in geriatric hip fracture patients.

This randomized controlled trial enrolled 283 geriatric patients (aged ≥65 years) undergoing operative treatment for femoral neck, intertrochanteric region, or subtrochanteric fractures at a single-center Level I trauma center. Patients were randomized to receive either preoperative intravenous tranexamic acid (TXA) or a placebo.

The primary outcome was postoperative transfusion. Results showed no significant difference between the TXA group and the placebo group, with 81% of patients in both groups requiring no transfusion (P = 0.97). Secondary outcomes, including hospital length of stay, 30-day readmission, 90-day complications, and 90-day mortality, also showed no significant differences between the two groups.

Subgroup analysis revealed that procedure type significantly influenced transfusion rates (P < 0.05), with higher rates in ORIF (25%) compared to arthroplasty (8%). However, there was no difference between TXA and placebo within these subgroups (P = 0.38). The trial was terminated early following an interim futility analysis. Safety data were not reported.

Because the study was stopped early for futility, the evidence regarding the specific impact of TXA on transfusion requirements in this population is limited. Clinical practice suggests that surgical procedure type may influence transfusion risk more than the administration of tranexamic acid.

How this fits prior evidence

How this fits prior evidence: This finding addresses a gap in understanding the role of tranexamic acid specifically for hip fracture management, contrasting with previous findings where TXA showed efficacy in other contexts. Specifically, while TXA was noted as an optimal intervention for mortality in TBI patients and shown to have varying efficacy for hemostasis in neonatal cardiac surgery, this study found no benefit for reducing transfusion in geriatric hip fractures.

When a person suffers a serious hip fracture, surgeons must act quickly to stabilize the bone. During these surgeries, doctors sometimes use a medication called tranexamic acid (TXA) to help control bleeding and reduce the need for blood transfusions. This study looked at whether TXA actually made a difference for older patients undergoing surgery for broken hips.

Researchers tracked 283 patients over several months. They compared those who received the drug before surgery against those who received a placebo. The results showed that both groups had nearly identical rates of needing a transfusion, with about 81% of patients in both groups avoiding one. Other measures, like how long patients stayed in the hospital or their risk of being readmitted within 30 days, also showed no significant difference between the two groups.

While the drug did not show a benefit for reducing transfusions, the study did find that the type of surgery performed played a much larger role. Patients undergoing one specific type of surgery had higher transfusion rates than those getting another. Because the trial was stopped early due to lack of evidence that the drug worked, it suggests that the surgical method itself may be more important than the use of tranexamic acid in these cases.

What this means for you:
Tranexamic acid did not reduce blood transfusion needs for patients undergoing surgery for hip fractures.

Common questions

Does tranexamic acid reduce the need for blood transfusions in hip surgery?

No, this study of 283 patients found no significant difference between those who received tranexamic acid and those who received a placebo. In both groups, about 81% of patients did not require a transfusion after their hip fracture surgery.

What other outcomes were affected by the use of tranexamic acid?

The study found no significant differences between the two groups regarding hospital length of stay, 30-day readmission rates, 90-day complications, or 90-day mortality. The results suggest that tranexamic acid did not change these common recovery metrics.

What did the study find about different types of hip surgery?

The type of procedure mattered more than the medication. Patients undergoing open reduction internal fixation (ORIF) had a 25% transfusion rate, while those receiving arthroplasty had an 8% rate. However, there was no difference in these rates between the tranexamic acid and placebo groups.

Study Details

Study typeRct
Sample sizen = 283
EvidenceLevel 2
Follow-up780.0 mo
PublishedJul 2026
View Original Abstract ↓
OBJECTIVES: To evaluate whether preoperative intravenous tranexamic acid (TXA) reduces postoperative blood transfusion rates in geriatric patients undergoing operative treatment for hip fracture. DESIGN: Prospective, double-blinded, randomized controlled trial terminated early after interim futility analysis. SETTING: Single-center Level I trauma center. PATIENT SELECTION CRITERIA: Patients aged ≥65 years who underwent operative treatment for femoral neck (AO/OTA 31-B), intertrochanteric region (AO/OTA 31-A), or subtrochanteric (AO/OTA 32-A/B/C) fractures between June 2019 and June 2022 were included. Procedures included arthroplasty (hemiarthroplasty or total hip arthroplasty) and internal fixation (ORIF) with intramedullary nailing or sliding hip screw fixation. Exclusion criteria were recent thromboembolic events, cancer, hypercoagulable disorders, or TXA allergy. OUTCOME MEASURES AND COMPARISONS: The primary outcome was postoperative transfusion. Secondary outcomes included hospital length of stay, 30-day readmission, and 90-day complications and mortality. Statistical comparisons were performed using odds ratios, chi-squared, and t-tests, with significance thresholds adjusted by O'Brien-Fleming criteria. RESULTS: A total of 283 patients were analyzed {TXA: 146 [mean age 84 (range 65-100), 71.9% female; placebo: 137 [mean age 83.1 (range 65-100), 77.2% female]}. Baseline characteristics, including body mass index and procedure type, were comparable (all P > 0.05). A total of 229 patients (80.9%) required no postoperative transfusion (TXA 81%; placebo: 81%, P = 0.97). No significant differences were observed in 30-day readmission ( P = 0.729), 90-day complications ( P = 0.183), hospital length of stay ( P = 0.783), or 90-day mortality ( P = 0.655). Subgroup analysis revealed higher transfusion rates in ORIF versus arthroplasty (ORIF 25%, arthroplasty 8%, P < 0.05), although no difference between TXA and placebo within subgroups ( P = 0.38). CONCLUSIONS: Preoperative TXA was not associated with reduced transfusion requirements in geriatric hip fracture surgery. No significant differences were observed in complications, mortality, or hospital stay. Surgical procedure may influence transfusion risk more than TXA use. LEVEL OF EVIDENCE: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
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