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Home › Medications › tranexamic acid

tranexamic acid

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of tranexamic acid

51 trials tracked of tranexamic acid: 31 in phase 3 or 4 and 7 with published results. The most-cited published study has 118 citations.

51Trials tracked
31Phase 3 & 4
0Recruiting
7With published results
Phase distribution
Phase 4 21 Phase 3 10 Phase 2 10 Phase 1 1 Other / NA 9
  1. Phase 3 Study of Tranexamic Acid During Air and Ground Medical Prehospital Transport Trial (STAAMP Trial) Completed · 118 cited
  2. Phase 3 Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean Completed · 115 cited
  3. Phase 4 Tranexamic Acid (TXA) Versus Epsilon Aminocaproic Acid (EACA) Versus Placebo for Spine Surgery Completed · 65 cited
  4. Phase 4 Tranexamic Acid in Knee Joint Surgery Completed · 38 cited
  5. Phase 3 Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery Completed · 13 cited
  6. Phase 4 Tranexamic Acid to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP) Completed · 11 cited
Show 44 more trials
  1. Phase 3 American Trial Using Tranexamic Acid in Thrombocytopenia Completed · 8 cited
  2. Phase 4 Does Tranexamic Acid Reduce the Need for Blood Transfusions in Patients Undergoing Hip Fracture Surgery? Completed
  3. Phase 4 Clinical Trial Comparing Tranexamic Acid (TXA) With Aquamantys Sealer in Total Knee Arthroplasty (TKA) Completed
  4. Phase 4 Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery Completed
  5. Phase 4 Tranexamic Acid in Adolescents With Heavy Menstrual Bleeding Completed
  6. Phase 4 Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery Completed
  7. Phase 4 Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study Completed
  8. Phase 4 Efficacy of Tranexamic Acid in Foot and Ankle Surgeries Completed
  9. Phase 4 Tranexamic Acid Dosing for Total Joint Arthroplasty Completed
  10. Phase 4 Reducing Hemarthrosis in ACL Reconstruction With BTB Autograft by the Administration of Intravenous TXA Completed
  11. Phase 4 Topical (Intra-Articular) Tranexamic Acid and Transfusion Rates Following Hip Hemiarthroplasty Completed
  12. Phase 4 A Study on the Safety of Tranexamic Acid for the Chronic Subdural Hematoma Population Completed
  13. Phase 4 Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids Completed
  14. Phase 4 Tranexamic Acid in Surgery of Advanced Ovarian Cancer Completed
  15. Phase 4 Use of Tranexamic Acid in Reduction Mammoplasty Completed
  16. Phase 4 Oral Versus Intravenous Tranexamic Acid Completed
  17. Phase 4 A Pilot Study Comparing Anti-Inflammatory Effects Of TXA Versus EACA In Pediatric Congenital Heart Surgery Completed
  18. Phase 4 Lysteda Pediatric Research Equity Act (PREA) Pharmacokinetic Study in Adolescent Females With Heavy Menstrual Bleeding Completed
  19. Phase 4 Prospective Trial of Tranexamic Acid in Cardiac Surgery Completed
  20. Phase 3 Tranexamic Acid in Reverse Total Shoulder Arthroplasty Completed
  21. Phase 3 The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery Completed
  22. Phase 3 Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section Completed
  23. Phase 3 Topical Application of Tranexamic Acid to Reduce Post-operative Bleeding in Coronary Artery Bypass Surgery Completed
  24. Phase 3 A Study of Tranexamic Acid (XP12B) in Women With Heavy Menstrual Bleeding Completed
  25. Phase 3 Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema (HAE) Completed
  26. Phase 2 The Use of Tranexamic Acid to Reduce Perioperative Blood Loss During High Risk Spine Fusion Surgery Completed
  27. Phase 2 The Effect of Tranexamic Acid on Postpartum Hemorrhage During and After Cesarean Delivery Completed
  28. Phase 2 North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Completed
  29. Phase 2 Tranexamic Acid Dosing for Major Joint Replacement Surgery Completed
  30. Phase 2 Prevention of Postpartum Hemorrhage With Tranexamic Acid Completed
  31. Phase 2 Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty Completed
  32. Phase 2 Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study Completed
  33. Phase 2 TXA in Spinal Fusion Completed
  34. Phase 2 Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury Completed
  35. Phase 2 Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery? Completed
  36. Phase 1 Topical Tranexamic Acid Use on Granulating Wounds Following Mohs Micrographic Surgery Completed
  37. N/A Efficacy of Tranexamic Acid for Reducing Blood Loss and Blood Transfusion After Periacetabular Osteotomy Completed
  38. N/A Hemostasis in Open Acetabulum and Pelvic Ring Surgery Using Tranexamic Acid Completed
  39. N/A Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Double Blind Randomized Placebo Controlled Clinical Trial Completed
  40. N/A TXA Study in Major Oncologic Surgery Completed
  41. N/A Tranexamic Acid in Off-pump Coronary Surgery Completed
  42. N/A Investigation of Intravenous Tranexamic Acid With Anatomic and Reverse Total Shoulder Arthroplasty Completed
  43. N/A Tranexamic Acid and Blood Clots in Knee Surgery Completed
  44. N/A Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery Completed

Showing the 50 most-cited and recently-updated of 51 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Aprotinin and tranexamic acid show varying efficacy for hemostasis in neonatal cardiac surgery
Pediatrics Meta-analysis
Aprotinin and tranexamic acid show varying efficacy for hemostasis in neonatal cardiac surgery Trial Shows Aprotinin May Reduce Blood Loss in Infant Heart Surgery
This network meta-analysis of 27 studies involving 4,556 patients evaluated various hemostatic strategies in neonatal and infant cardiac sur…
A large review of 4,556 patients suggests aprotinin may be more effective than other treatments for managing blood loss during infant heart …
Frontiers Jun 10, 2026
Tranexamic acid reduces mortality in TBI patients with high brain voxel percentages
Radiology & Imaging RCT
Tranexamic acid reduces mortality in TBI patients with high brain voxel percentages Trial shows brain imaging helps identify patients who benefit from TXA
This post hoc analysis of an RCT involving 550 patients with moderate or severe traumatic brain injury (TBI) evaluated the impact of tranexa…
A new analysis suggests that specific brain scans can help doctors identify which traumatic brain injury patients might benefit most from a …
Jun 9, 2026
Tranexamic acid reduces postpartum haemorrhage in placenta praevia caesarean delivery
Drug Pipeline RCT
Tranexamic acid reduces postpartum haemorrhage in placenta praevia caesarean delivery New Drug Cuts Heavy Bleeding Risk After C Section Births
This phase 3 randomized controlled trial in 1732 women with placenta praevia undergoing caesarean delivery found that prophylactic tranexami…
A common drug given during C sections cuts heavy bleeding risk for women with placenta praevia, a dangerous pregnancy condition affecting th…
May 14, 2026
Tranexamic acid reduces blood loss in posterior lumbar fusion with anticoagulants
Rheumatology Cohort
Tranexamic acid reduces blood loss in posterior lumbar fusion with anticoagulants Giving a clot-busting drug before surgery reduced blood loss during spinal fusion
This retrospective case–control study of patients undergoing posterior lumbar interbody fusion found that intravenous tranexamic acid was as…
Patients on blood thinners who got a specific clot-preventing drug before spinal surgery lost less blood during the operation and needed les…
Frontiers Apr 24, 2026
General Anesthesia Associated With Increased Severe Postpartum Hemorrhage Risk Compared to Neuraxial Anesthesia in Cesarean Deliveries
Emergency Medicine Cohort
General Anesthesia Associated With Increased Severe Postpartum Hemorrhage Risk Compared to Neuraxial Anesthesia in Cesarean Deliveries General anesthesia in emergency cesareans linked to higher severe bleeding risk compared to neuraxial options
This retrospective dual-cohort study evaluated patients receiving general or neuraxial anesthesia during emergency cesarean deliveries and p…
Patients receiving general anesthesia during emergency cesarean deliveries faced nearly three times the risk of severe bleeding compared to …
Frontiers Apr 22, 2026