A rare case report shows intravenous methylprednisolone therapy improved neurological symptoms in a woman with autoimmune nodopathy

This case report describes a 45-year-old woman who suffered from autoimmune nodopathy, a rare condition that can affect nerves and kidneys. She also had Sjögren's disease and nephrotic syndrome. Her main problem was severe neurological symptoms that did not respond well to intravenous immunoglobulin treatment. Doctors then gave her intravenous methylprednisolone therapy. Her neurological symptoms improved significantly after this treatment. The report also notes that she had massive proteinuria, a postural tremor, and specific antibodies in her blood. These clues help doctors identify the condition early. The study found that anti-CNTN1 antibodies may cause injury to both the peripheral nerves and kidneys by targeting shared antigens. This is an exceptionally rare comorbid phenotype. Clinicians should recognize these key diagnostic clues to facilitate early identification. The report does not report any adverse events or discontinuations. This single case highlights how specific antibody markers can guide treatment choices for rare autoimmune disorders.