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Home › Medications › methylprednisolone

methylprednisolone

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of methylprednisolone

87 trials tracked of methylprednisolone: 39 in phase 3 or 4 and 16 with published results. The most-cited published study has 251 citations.

87Trials tracked
39Phase 3 & 4
0Recruiting
16With published results
Phase distribution
Phase 4 17 Phase 3 22 Phase 2 40 Phase 1 3 Other / NA 5
  1. Phase 3 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 251 cited
  2. Phase 3 05-001: Treatment of Acute Lymphoblastic Leukemia in Children Completed · 241 cited
  3. Phase 3 Extended Steroid in Use in Community Acquired Pneumonia (CAP)(e) Completed · 212 cited
  4. Phase 3 Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease Completed · 167 cited
  5. Phase 3 Stem Cell Transplant (SCT) for Dyskeratosis Congenita or SAA Completed · 153 cited
  6. Phase 4 Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI) Completed · 133 cited
Show 44 more trials
  1. Phase 3 Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest Completed · 127 cited
  2. Phase 3 Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis Completed · 102 cited
  3. Phase 3 STeroids to REduce Systemic Inflammation After Infant Heart Surgery Completed · 73 cited
  4. Phase 3 GRAVITAS-301: A Study of Itacitinib or Placebo in Combination With Corticosteroids for Treatment of Acute Graft-Versus-Host Disease Completed · 61 cited
  5. Phase 4 Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout Completed · 56 cited
  6. Phase 3 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 37 cited
  7. Phase 4 Preoperative High Dose Steroids for Liver Resection- Effect on Complications in the Immediate Postoperative Period Completed · 22 cited
  8. Phase 4 Corticosteroids for Acute Migraine in the Emergency Department Completed · 20 cited
  9. Phase 3 MIS-C Comparative Effectiveness Study Completed · 6 cited
  10. Phase 4 Psoriatic Oligoarthritis Intervention With Symptomatic thErapy Completed · 2 cited
  11. Phase 4 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed
  12. Phase 4 Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis Completed
  13. Phase 4 The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI) Completed
  14. Phase 4 Belatacept Compared to Tacrolimus in Deceased Donor Renal Transplant Recipients Completed
  15. Phase 4 Differences in Flare Reaction Incidence and Intensity Following Trigger Finger Injections Completed
  16. Phase 4 A Study of Glucocorticoid Use to Evaluate Systematic Methylprednisolone Reduction in Patients With Rheumatoid Arthritis on Background RoActemra/Actemra (Tocilizumab) (ACT-ALONE) Completed
  17. Phase 4 A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate Completed
  18. Phase 4 A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis Completed
  19. Phase 4 Desensitization in Kidney Transplantation Completed
  20. Phase 4 Greater Occipital Nerve Block for Migraine Prophylaxis Completed
  21. Phase 4 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed
  22. Phase 4 Cyclosporine A C-2h Monitoring Versus Tacrolimus C-0h Monitoring in de Novo Liver Transplant Recipients Completed
  23. Phase 3 A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid Arthritis Completed
  24. Phase 3 A Study of MabThera/Rituxan (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis and Inadequate Response to DMARD Therapy Completed
  25. Phase 3 A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy Completed
  26. Phase 3 A Study to Evaluate the Efficacy and Safety of Rituximab in Subjects With International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 Class III or IV Lupus Nephritis Completed
  27. Phase 3 A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed
  28. Phase 3 Canadian Cardiology de Novo Study: A Comparison Between Tacrolimus- and Cyclosporine- Based Immunoprophylactic Regimens Completed
  29. Phase 3 A Study to Evaluate the Safety and Efficacy of Rituximab in Combination With Methotrexate Compared to Methotrexate Alone in Patients With Active Rheumatoid Arthritis Completed
  30. Phase 3 Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease Completed
  31. Phase 3 Trial of Rituximab for Graves' Ophthalmopathy Completed
  32. Phase 3 OPERA Study: A Study of Two Dosing Regimens of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients. Completed
  33. Phase 3 Sudden Deafness Treatment Trial Completed
  34. Phase 2 Belatacept Pilot Study in Lung Transplantation Immunosuppression in Lung Transplantation Completed
  35. Phase 2 Treg Modulation With CD28 and IL-6 Receptor Antagonists Completed
  36. Phase 2 NMA Allogeneic Hematopoietic Cell Transplant in Hematologic Cancer/Disorders Completed
  37. Phase 2 Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders Completed
  38. Phase 2 Effects of Inhibiting Early Inflammation in Kidney Transplant Patients Completed
  39. Phase 2 Randomized Trial for Mixed Acute Rejection Completed
  40. Phase 2 A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving Methotrexate Completed
  41. Phase 2 Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation Completed
  42. Phase 2 Cytoxan, Fludara, and Antithymocyte Globulin Conditioning Followed By Stem Cell Transplant in Treating Fanconi Anemia Completed
  43. Phase 2 A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant Completed
  44. Phase 2 Lymphocyte Depletion and Stem Cell Transplantation to Treat Severe Systemic Lupus Erythematosus Completed

Showing the 50 most-cited and recently-updated of 87 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Refractory mastoiditis may signal granulomatosis with polyangiitis: case highlights need for early ANCA testing
Allergy & Immunology Sys. Review
Refractory mastoiditis may signal granulomatosis with polyangiitis: case highlights need for early ANCA testing Mastoiditis May Be Linked to Granulomatosis with Polyangiitis
A case report and literature review describes a 69-year-old woman with refractory mastoiditis later diagnosed as granulomatosis with polyang…
A persistent ear infection in an older patient revealed a rare underlying autoimmune condition called granulomatosis with polyangiitis.
Frontiers Jun 29, 2026
Higher admission WBC predicts favorable methylprednisolone effect after thrombectomy
Neurology RCT
Higher admission WBC predicts favorable methylprednisolone effect after thrombectomy Higher white blood cell counts linked to better methylprednisolone effects in stroke patients
This secondary analysis of a randomized, placebo-controlled trial evaluated 1201 patients with anterior-circulation large-vessel occlusion s…
A secondary analysis suggests higher white blood cell counts may predict better outcomes when adding methylprednisolone to stroke treatment …
Jun 1, 2026
Rituximab rechallenge caused severe hypersensitivity reaction in a patient with membranous nephropathy
Drug Pipeline Sys. Review
Rituximab rechallenge caused severe hypersensitivity reaction in a patient with membranous nephropathy A third Rituximab dose caused severe shock in a man with kidney disease
This case report describes a 52-year-old male with biopsy-proven primary membranous nephropathy who received a third 1 g infusion of rituxim…
A man with kidney disease developed life-threatening shock after a third Rituximab infusion, highlighting the need for careful monitoring an…
Frontiers May 29, 2026
Review of ruxolitinib for systemic juvenile arthritis with macrophage activation syndrome
Pediatrics Sys. Review
Review of ruxolitinib for systemic juvenile arthritis with macrophage activation syndrome Two children with severe arthritis found relief using a new drug approach
This narrative review synthesizes a retrospective case series and literature search on ruxolitinib for systemic juvenile idiopathic arthriti…
Two children with severe arthritis complications found relief using a new drug approach, offering hope for those who struggle with standard …
Frontiers May 28, 2026
Case report and review on autoimmune nodopathy with Sjogren's disease and nephrotic syndrome
Allergy & Immunology Sys. Review
Case report and review on autoimmune nodopathy with Sjogren's disease and nephrotic syndrome A rare case report shows intravenous methylprednisolone therapy improved neurological symptoms in a woman with autoimmune nodopathy
This is a case report and literature review on a 45-year-old woman with autoimmune nodopathy, Sjogren's disease, and nephrotic syndrome. The…
A 45-year-old woman with autoimmune nodopathy saw her neurological symptoms improve significantly after receiving intravenous methylpredniso…
Frontiers May 25, 2026
Songjiao Dihuang Tang for Immune Checkpoint Inhibitor-Associated Myocarditis: Trial Protocol
Drug Pipeline RCT
Songjiao Dihuang Tang for Immune Checkpoint Inhibitor-Associated Myocarditis: Trial Protocol Chinese herbal formula tested for immunotherapy heart side effect
This protocol describes a multicenter, double-blind RCT of Songjiao Dihuang Tang plus standard care vs placebo in 200 patients with mild ICI…
A new trial will test if a traditional Chinese herbal formula can protect cancer patients from a rare but serious heart complication caused …
Frontiers May 16, 2026
Case report and literature review of severe adverse reactions following pucotenlimab treatment
Allergy & Immunology Sys. Review
Case report and literature review of severe adverse reactions following pucotenlimab treatment New drug treatment linked to severe neurological reactions
This case report and literature review describes severe adverse reactions following treatment with pucotenlimab in a patient with advanced b…
A single patient facing advanced breast cancer experienced life-threatening neurological symptoms after receiving the drug pucotenlimab.
Frontiers Apr 30, 2026
Case report describes sintilimab-associated toxic epidermal necrolysis in gastric carcinoma patient
Oncology Sys. Review
Case report describes sintilimab-associated toxic epidermal necrolysis in gastric carcinoma patient Rare Skin Reaction Follows Successful Stomach Cancer Therapy
This case report details a patient with gastric carcinoma developing delayed-onset toxic epidermal necrolysis during neoadjuvant sintilimab …
A new case shows a common stomach cancer drug can cause dangerous skin reactions even after surgery.
Frontiers Apr 22, 2026
Retrospective review of methylprednisolone response in children with TBX4-associated pulmonary hypertension and interstitial lung disease
Pulmonology & Critical Care
Retrospective review of methylprednisolone response in children with TBX4-associated pulmonary hypertension and interstitial lung disease Pulsed steroids may help children with TBX4-linked lung disease and pulmonary hypertension
This review examines a retrospective cohort of 21 children with TBX4-associated pulmonary hypertension treated with methylprednisolone.
Pulsed steroids helped most children with TBX4-linked lung disease improve breathing and heart function without significant side effects.
medRxiv Apr 20, 2026
Case Report Details Aumolertinib Rechallenge Following Osimertinib-Induced Interstitial Lung Disease in Lung Adenocarcinoma
Drug Pipeline Guideline
Case Report Details Aumolertinib Rechallenge Following Osimertinib-Induced Interstitial Lung Disease in Lung Adenocarcinoma Can lung cancer drugs be restarted after severe lung injury?
This case report describes a 73-year-old male with stage IV lung adenocarcinoma and EGFR exon 19 deletions who experienced interstitial lung…
Doctors successfully restarted a powerful lung cancer drug after a patient's lungs healed from a dangerous reaction to the first one.
Frontiers Apr 19, 2026
Infliximab in IVIG-resistant Kawasaki disease with cholestatic hepatitis: case report
Pediatrics RCT
Infliximab in IVIG-resistant Kawasaki disease with cholestatic hepatitis: case report Can a new drug stop heart damage in Kawasaki disease when standard treatments fail?
A case report describes a 2-year-old Han Chinese male with IVIG-resistant Kawasaki disease and cholestatic hepatitis treated with infliximab…
In a two-year-old boy with Kawasaki disease, the drug infliximab quickly stopped his fever and liver trouble, yet his heart artery damage ke…
Frontiers Apr 16, 2026
Hospitalized AE-RA-ILD patients receiving JAK inhibitors alongside glucocorticoids showed mixed respiratory outcomes over three months
Psychiatry Cohort
Hospitalized AE-RA-ILD patients receiving JAK inhibitors alongside glucocorticoids showed mixed respiratory outcomes over three months A Rheumatoid Arthritis Drug May Help Save Lungs in Crisis
This retrospective observational case series examined six consecutive patients hospitalized for acute exacerbation of rheumatoid arthritis–a…
A small study suggests a familiar arthritis pill may help calm sudden, dangerous lung flare-ups in people with rheumatoid arthritis.
Frontiers Apr 16, 2026

All methylprednisolone Articles