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Home › Medications › methylprednisolone

methylprednisolone

23 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of methylprednisolone

87 trials tracked of methylprednisolone: 39 in phase 3 or 4 and 16 with published results. The most-cited published study has 245 citations.

87Trials tracked
39Phase 3 & 4
0Recruiting
16With published results
Phase distribution
Phase 4 17 Phase 3 22 Phase 2 40 Phase 1 3 Other / NA 5
  1. Phase 3 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 245 cited
  2. Phase 3 05-001: Treatment of Acute Lymphoblastic Leukemia in Children Completed · 241 cited
  3. Phase 3 Extended Steroid in Use in Community Acquired Pneumonia (CAP)(e) Completed · 220 cited
  4. Phase 3 Transtympanic Gentamicin vs. Steroids in Refractory Meniere's Disease Completed · 176 cited
  5. Phase 3 Stem Cell Transplant (SCT) for Dyskeratosis Congenita or SAA Completed · 151 cited
  6. Phase 4 Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI) Completed · 135 cited
Show 44 more trials
  1. Phase 3 Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest Completed · 126 cited
  2. Phase 3 Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis Completed · 104 cited
  3. Phase 3 STeroids to REduce Systemic Inflammation After Infant Heart Surgery Completed · 76 cited
  4. Phase 3 GRAVITAS-301: A Study of Itacitinib or Placebo in Combination With Corticosteroids for Treatment of Acute Graft-Versus-Host Disease Completed · 67 cited
  5. Phase 4 Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout Completed · 62 cited
  6. Phase 3 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 33 cited
  7. Phase 4 Preoperative High Dose Steroids for Liver Resection- Effect on Complications in the Immediate Postoperative Period Completed · 22 cited
  8. Phase 4 Corticosteroids for Acute Migraine in the Emergency Department Completed · 20 cited
  9. Phase 3 MIS-C Comparative Effectiveness Study Completed · 9 cited
  10. Phase 4 Psoriatic Oligoarthritis Intervention With Symptomatic thErapy Completed · 3 cited
  11. Phase 4 A Study to Evaluate the Efficacy and Safety of Zenapax in Combination With CellCept, Cyclosporine, and Corticosteroids in Patients Undergoing Cardiac Transplantation Completed
  12. Phase 4 Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis Completed
  13. Phase 4 The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI) Completed
  14. Phase 4 Belatacept Compared to Tacrolimus in Deceased Donor Renal Transplant Recipients Completed
  15. Phase 4 Differences in Flare Reaction Incidence and Intensity Following Trigger Finger Injections Completed
  16. Phase 4 A Study of Glucocorticoid Use to Evaluate Systematic Methylprednisolone Reduction in Patients With Rheumatoid Arthritis on Background RoActemra/Actemra (Tocilizumab) (ACT-ALONE) Completed
  17. Phase 4 A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate Completed
  18. Phase 4 A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid Arthritis Completed
  19. Phase 4 Desensitization in Kidney Transplantation Completed
  20. Phase 4 Greater Occipital Nerve Block for Migraine Prophylaxis Completed
  21. Phase 4 Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection Completed
  22. Phase 4 Cyclosporine A C-2h Monitoring Versus Tacrolimus C-0h Monitoring in de Novo Liver Transplant Recipients Completed
  23. Phase 3 A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid Arthritis Completed
  24. Phase 3 A Study of MabThera/Rituxan (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis and Inadequate Response to DMARD Therapy Completed
  25. Phase 3 A 3-arm Multi-center, Randomized Controlled Study Comparing Transforaminal Corticosteroid, Transforaminal Etanercept and Transforaminal Saline for Lumbosacral Radiculopathy Completed
  26. Phase 3 A Study to Evaluate the Efficacy and Safety of Rituximab in Subjects With International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2003 Class III or IV Lupus Nephritis Completed
  27. Phase 3 A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed
  28. Phase 3 Canadian Cardiology de Novo Study: A Comparison Between Tacrolimus- and Cyclosporine- Based Immunoprophylactic Regimens Completed
  29. Phase 3 A Study to Evaluate the Safety and Efficacy of Rituximab in Combination With Methotrexate Compared to Methotrexate Alone in Patients With Active Rheumatoid Arthritis Completed
  30. Phase 3 Low-Dose Prednisone or Methylprednisolone in Treating Patients With Newly Diagnosed Acute Graft-versus-Host Disease Completed
  31. Phase 3 Trial of Rituximab for Graves' Ophthalmopathy Completed
  32. Phase 3 OPERA Study: A Study of Two Dosing Regimens of CellCept (Mycophenolate Mofetil) in Kidney Transplant Patients. Completed
  33. Phase 3 Sudden Deafness Treatment Trial Completed
  34. Phase 2 Belatacept Pilot Study in Lung Transplantation Immunosuppression in Lung Transplantation Completed
  35. Phase 2 Treg Modulation With CD28 and IL-6 Receptor Antagonists Completed
  36. Phase 2 NMA Allogeneic Hematopoietic Cell Transplant in Hematologic Cancer/Disorders Completed
  37. Phase 2 Alemtuzumab, Fludarabine, and Busulfan Followed By Donor Stem Cell Transplant in Treating Young Patients With Hematologic Disorders Completed
  38. Phase 2 Effects of Inhibiting Early Inflammation in Kidney Transplant Patients Completed
  39. Phase 2 Randomized Trial for Mixed Acute Rejection Completed
  40. Phase 2 A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving Methotrexate Completed
  41. Phase 2 Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation Completed
  42. Phase 2 Cytoxan, Fludara, and Antithymocyte Globulin Conditioning Followed By Stem Cell Transplant in Treating Fanconi Anemia Completed
  43. Phase 2 A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant Completed
  44. Phase 2 Lymphocyte Depletion and Stem Cell Transplantation to Treat Severe Systemic Lupus Erythematosus Completed

Showing the 50 most-cited and recently-updated of 87 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
EV-D68 infection may cause plastic bronchitis and severe pneumonia in pediatric patients
Cardiology Sys. Review
EV-D68 infection may cause plastic bronchitis and severe pneumonia in pediatric patients EV-D68 Infection Linked to Severe Lung Issues in Children
This case report and literature review describes a single 11-year-old girl with Enterovirus D68 infection leading to plastic bronchitis and …
A new case report identifies Enterovirus D68 as a potential cause of severe pneumonia and plastic bronchitis in children.
Frontiers Oct 17, 2026
G-CSF shows potential signal for neurological grade improvement in acute spinal cord injury
Drug Pipeline Meta-analysis
G-CSF shows potential signal for neurological grade improvement in acute spinal cord injury G-CSF Shows Potential for Improving Spinal Cord Injury Recovery
This meta-analysis evaluates the efficacy of G-CSF, EPO, MP, and minocycline for neurological grade improvement in acute spinal cord injury.…
A review of treatments for acute spinal cord injury suggests that G-CSF may help improve neurological grades, though more evidence is needed…
Frontiers Oct 11, 2026
IVMP plus efgartigimod ranked highest for mRS improvement in autoimmune encephalitis network meta-analysis
Allergy & Immunology Meta-analysis
IVMP plus efgartigimod ranked highest for mRS improvement in autoimmune encephalitis network meta-analysis Comparing Different Treatment Options for Patients with Autoimmune Encephalitis
This network meta-analysis of 1,359 patients evaluated acute-phase immunotherapeutic strategies for autoimmune encephalitis. The study found…
Doctors are looking for the best way to treat brain inflammation. New data compares several common therapies to find the most effective opti…
Frontiers Oct 8, 2026
Serplulimab induced grade 4 checkpoint inhibitor pneumonitis in an elderly patient with SCLC and COPD
Oncology Sys. Review
Serplulimab induced grade 4 checkpoint inhibitor pneumonitis in an elderly patient with SCLC and COPD New cancer treatment causes severe lung inflammation in elderly patients
This case report describes a grade 4 serplulimab-induced checkpoint inhibitor pneumonitis in an 80-year-old man with extensive-stage small c…
A new cancer drug caused severe, life-threatening lung inflammation in an 80-year-old man with existing lung disease.
Frontiers Oct 7, 2026
Intravenous pantoprazole may trigger life-threatening Type I Kounis syndrome in patients with bronchial asthma
Cardiology Sys. Review
Intravenous pantoprazole may trigger life-threatening Type I Kounis syndrome in patients with bronchial asthma Pantoprazole May Trigger Rare Heart Complications in Asthma Patients
This case report and literature review describes a single instance of Type I Kounis syndrome following intravenous pantoprazole administrati…
A rare case shows how a common acid reflux medication may cause a severe heart reaction in a patient with a history of asthma.
Frontiers Sep 29, 2026
Anti-GBM disease can emerge after apparent remission of ANCA-associated vasculitis in elderly patients
Nephrology Sys. Review
Anti-GBM disease can emerge after apparent remission of ANCA-associated vasculitis in elderly patients New antibody testing may help catch hidden kidney disease
This case report and literature review describes an 85-year-old woman with ANCA-associated vasculitis who developed subsequent anti-GBM dise…
A case study shows that a patient with one type of kidney inflammation developed a second, hidden condition.
Frontiers Sep 28, 2026
Pembrolizumab-induced myositis and cardiogenic shock may be reversible with early immunosuppression and circulatory support
Cardiology Sys. Review
Pembrolizumab-induced myositis and cardiogenic shock may be reversible with early immunosuppression and circulatory support Immune therapy for thymoma can cause severe heart and muscle damage
This case report and literature review describes a patient with stage IV thymoma who developed severe myositis and cardiogenic shock followi…
A new case report reveals how a specific cancer treatment can cause severe heart and muscle issues, requiring intensive life support.
Frontiers Sep 11, 2026
Autoantibody positivity and false-negative cytology can mask invasive mucinous adenocarcinoma in patients with IPAF
Allergy & Immunology Sys. Review
Autoantibody positivity and false-negative cytology can mask invasive mucinous adenocarcinoma in patients with IPAF Lung cancer can mimic autoimmune lung disease in some patients
This case report describes a 78-year-old female with invasive mucinous adenocarcinoma and interstitial pneumonia with autoimmune features. T…
A new case shows how a rare lung cancer can look like an autoimmune disease, making it hard for doctors to tell them apart.
Frontiers Sep 8, 2026
Vunakizumab may induce severe ulcerative colitis and hepatic enzyme elevation in patients with psoriatic arthritis
Allergy & Immunology Sys. Review
Vunakizumab may induce severe ulcerative colitis and hepatic enzyme elevation in patients with psoriatic arthritis Vunakizumab Linked to Severe Ulcerative Colitis in Single Case
This case report and literature review describes a single case of severe ulcerative colitis and hepatic enzyme elevation following vunakizum…
A single case report shows a patient developed severe ulcerative colitis and high liver enzymes after receiving vunakizumab injections.
Frontiers Sep 4, 2026
Vasopressin, steroids, and epinephrine triple therapy improves ROSC in in-hospital cardiac arrest
Cardiology Meta-analysis
Vasopressin, steroids, and epinephrine triple therapy improves ROSC in in-hospital cardiac arrest Triple Therapy Shows Promise in Improving Cardiac Arrest Outcomes
This meta-analysis of 3 randomized trials and a network meta-analysis of 21,768 patients evaluates vasopressin, steroids, and epinephrine (V…
A triple therapy of vasopressin, steroids, and epinephrine showed a link to better circulation after cardiac arrest.
Frontiers Aug 5, 2026
Refractory mastoiditis may signal granulomatosis with polyangiitis: case highlights need for early ANCA testing
Allergy & Immunology Sys. Review
Refractory mastoiditis may signal granulomatosis with polyangiitis: case highlights need for early ANCA testing Mastoiditis May Be Linked to Granulomatosis with Polyangiitis
A case report and literature review describes a 69-year-old woman with refractory mastoiditis later diagnosed as granulomatosis with polyang…
A persistent ear infection in an older patient revealed a rare underlying autoimmune condition called granulomatosis with polyangiitis.
Frontiers Jun 29, 2026
Higher admission WBC predicts favorable methylprednisolone effect after thrombectomy
Neurology RCT
Higher admission WBC predicts favorable methylprednisolone effect after thrombectomy Higher white blood cell counts linked to better methylprednisolone effects in stroke patients
This secondary analysis of a randomized, placebo-controlled trial evaluated 1201 patients with anterior-circulation large-vessel occlusion s…
A secondary analysis suggests higher white blood cell counts may predict better outcomes when adding methylprednisolone to stroke treatment …
Jun 1, 2026

All methylprednisolone Articles