Lab tests suggest CBD may help treat cancer in dogs

A systematic review examined pre-clinical studies on how cannabidiol (CBD) affects cancer cells in dogs. The research focused on lymphoma, mammary cancer, glioma, prostate cancer, osteosarcoma, and urothelial carcinoma. These studies were mostly based on cellular models rather than living animals or people. The review found that CBD exerts antiproliferative and proapoptotic effects, meaning it can slow cancer cell growth and encourage cell death. It also modulates intracellular signaling pathways like ERK, JNK, and caspases. Additionally, the review noted that CBD can have synergistic or antagonistic effects when combined with other drugs. Safety data indicated that CBD was safe and well-tolerated in these pre-clinical settings. However, the review highlighted that fewer publications are available for dogs compared to humans. There was also no comprehensive review of findings performed prior to this study. The authors noted a need to better elucidate mechanisms and standardize concentrations and formulations. Readers should understand that these findings highlight potential uses but do not prove effectiveness in real-world dog patients yet.