Doctors tested a medicine called pregabalin on 729 people who had painful nerve pain from diabetes. The patients took different amounts of the drug every day for five to eight weeks. Some took 75 or 150 mg, while others took 300 or 600 mg. Others took a fake pill that looked the same but had no medicine inside.
The main goal was to see if the medicine could lower pain levels. The results showed that the higher doses worked very well. Patients taking 300 mg or 600 mg felt much less pain than those taking the fake pill. The lower doses did not show this same benefit for most people in the group.
This finding is important because it helps doctors choose the right amount of medicine. It does not matter if a patient has high or low blood sugar control. The best pain relief came from the higher doses of the drug. No serious safety problems were reported during the study.