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Home › Medications › pregabalin

pregabalin

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of pregabalin

94 trials tracked of pregabalin: 69 in phase 3 or 4 and 16 with published results. The most-cited published study has 104 citations.

94Trials tracked
69Phase 3 & 4
0Recruiting
16With published results
Phase distribution
Phase 4 27 Phase 3 42 Phase 2 15 Phase 1 3 Other / NA 7
  1. Phase 3 Efficacy & Safety Study of Pregabalin to Treat Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) Completed · 104 cited
  2. Phase 4 MAST Trial: Multi-modal Analgesic Strategies in Trauma Completed · 51 cited
  3. Phase 4 Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations Completed · 47 cited
  4. Phase 4 Pregabalin In Adolescent Patients With Fibromyalgia Completed · 46 cited
  5. Phase 3 Once-A-Day Pregabalin For Partial Seizures Completed · 34 cited
  6. Phase 3 Placebo-controlled Safety and Efficacy Study of Pregabalin in Subjects With Post-traumatic Peripheral Neuropathic Pain Completed · 30 cited
Show 44 more trials
  1. Phase 3 Treatment of Pain Associated With Fibromyalgia Completed · 30 cited
  2. Phase 3 Treatment of Pain Associated With Fibromyalgia Completed · 30 cited
  3. Phase 3 Treatment of Pain Associated With Fibromyalgia Completed · 30 cited
  4. Phase 4 A Study of Duloxetine (LY248686) in Participants With Diabetic Peripheral Neuropathic Pain (DPNP) Completed · 28 cited
  5. Phase 3 Study Of A Controlled Release Formulation Of Pregabalin In Fibromyalgia Patients Completed · 26 cited
  6. Phase 4 Prophylactic Pregabalin to Decrease Pain During Medical Abortion Completed · 24 cited
  7. Phase 3 A Study For Pregabalin In Patients With Fibromyalgia Completed · 21 cited
  8. Phase 3 Can Pregabalin Reduce the Frequency and Severity of Dry Eye Symptoms After Laser-assisted in Situ Keratomileusis? Completed · 16 cited
  9. Phase 4 Simulated Driving Performance, Daytime Sedation and Cognition in Healthy Volunteers Taking Gralise, Neurontin or Lyrica Completed · 8 cited
  10. Phase 4 A Multimodal Analgesia Protocol Adapted for Ambulatory Surgery Completed · 6 cited
  11. Phase 4 Lumbar Stenosis Outcomes Research (LUSTOR) Completed
  12. Phase 4 Effect of Pregabalin on Post Operative Pain in Abdominal Hysterectomy Under Spinal Anesthesia With Intrathecal Morphine Completed
  13. Phase 4 Preoperative Pain Control in Gastric Bypass Surgery Patients Completed
  14. Phase 4 Lyrica (Pregabalin) Administered as an Add-on Therapy for Partial Seizures (LEADER). Completed
  15. Phase 4 Pregabalin and Post-thoracotomy Pain Completed
  16. Phase 4 A Randomized Double-Blind Study Testing the Effects of Pregabalin on Diabetic Neuropathy Completed
  17. Phase 4 Pregabalin on Colonic Motor and Sensory Function in Constipation Predominant Irritable Bowel Syndrome Completed
  18. Phase 4 P4 (Pregabalin for Peripheral Posttraumatic Pain) Completed
  19. Phase 4 Perioperative Administration of Pregabalin for Pain After Robot-assisted Endoscopic Thyroidectomy Completed
  20. Phase 4 Efficacy Of Pregabalin In Subjects With Post-Stroke Central Neuropathic Pain Completed
  21. Phase 4 Perioperative Administration of Pregabalin for Pain After Mastectomy Completed
  22. Phase 4 Pregabalin and Colonic Function Completed
  23. Phase 4 Analgetic and Anxiolytic Effect of Preoperative Pregabalin Completed
  24. Phase 4 Evaluation Of Sperm Production With Healthy Male Volunteers Receiving Lyrica Or Placebo Completed
  25. Phase 4 Efficacy of Pregabalin in Patients With Radicular Pain Completed
  26. Phase 4 An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain Completed
  27. Phase 4 Safety and Efficacy Evaluation Of Pregabalin (Lyrica) With Patients With Generalized Anxiety Disorder Completed
  28. Phase 4 Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures Completed
  29. Phase 4 Efficacy and Safety of Gabapentin/B-complex Versus Pregabalin in Diabetic Peripheral Neuropathy Pain Management Completed
  30. Phase 4 Pregabalin Treatment Of Peripheral Neuropathic Pain Associated With Diabetic Peripheral NeP (DPN), Postherpetic Neuralgia (PHN), HIV-related NeP (HIV), and Chemotherapy Induced NeP Completed
  31. Phase 3 A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures Completed
  32. Phase 3 Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery Completed
  33. Phase 3 Study To Evaluate Efficacy, Safety And Tolerability Of Lyrica In Patients With Painful Diabetic Peripheral Neuropathy Completed
  34. Phase 3 A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Postherpetic Neuralgia Completed
  35. Phase 3 A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy Completed
  36. Phase 3 Randomized, Double-Blind, Placebo-Controlled Study Of Pregabalin In Patients With Fibromyalgia Completed
  37. Phase 3 Efficacy And Safety Of Pregabalin For Pain Following Total Knee Replacement Completed
  38. Phase 3 Extension Study Of Long-Term Safety And Efficacy Of Pregabalin As Monotherapy (Lyrica) In Patients With Partial Seizures Completed
  39. Phase 3 Open Label Safety And Efficacy Study Of Pregabalin In Subjects With Nerve Pain Asociated With Human Immunodeficiency Virus (HIV) Neuropathy Completed
  40. Phase 3 Efficacy and Safety Study of Pregabalin in the Treatment of Pain on Walking in Patients With Diabetic Peripheral Neuropathy (DPN) Completed
  41. Phase 3 Study Of The Safety And Efficacy Of Lyrica In The Treatment Of Newly Diagnosed Partial Epilepsy Completed
  42. Phase 3 A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury Completed
  43. Phase 3 Pregabalin in Treating Women With Hot Flashes Completed
  44. Phase 3 A Study in Painful Diabetic Neuropathy Completed

Showing the 50 most-cited and recently-updated of 94 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Pregabalin 300 or 600 mg/day significantly reduces pain in painful diabetic peripheral neuropathy versus placebo
Diabetes & Endocrinology RCT
Pregabalin 300 or 600 mg/day significantly reduces pain in painful diabetic peripheral neuropathy versus placebo Higher doses of pregabalin helped reduce pain scores for people with painful diabetic nerve problems compared to placebo
This randomized controlled trial enrolled 729 patients with painful diabetic peripheral neuropathy. Pregabalin doses of 300 mg/day and 600 m…
A study found that taking 300 or 600 mg of pregabalin daily lowered pain scores better than a fake pill. Lower doses did not work as well fo…
May 5, 2026
Retrospective cross-sectional study characterizes arachnoiditis patient presentation and treatment responses in 1105 participants
Neurology
Retrospective cross-sectional study characterizes arachnoiditis patient presentation and treatment responses in 1105 participants Back Pain That Won't Go Away
This retrospective cross-sectional study characterized clinical presentation, comorbidities, and treatments in 1105 participants with physic…
A massive online community of chronic pain patients helped researchers finally map the symptoms and treatments for the often missed conditio…
medRxiv Apr 15, 2026