A review explains which drugs may cause severe skin reactions like Stevens-Johnson Syndrome

Severe skin reactions are scary. Conditions like Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis can happen when the body attacks its own skin. This review gathers information about many different medicines to see which ones might trigger these problems. It covers antibiotics, antiepileptics, allopurinol, and nonsteroidal anti-inflammatory drugs. It also looks at proton pump inhibitors, immune checkpoint inhibitors, novel antiandrogens, carbonic anhydrase inhibitors, and antivirals. The goal is to help healthcare providers make safer choices for their patients. Understanding these links is vital for preventing harm before it starts. Because this is a narrative review, it summarizes existing reports rather than testing new drugs in a clinical trial. The authors carefully note that the evidence comes from various sources and does not always prove a direct cause and effect. Readers should know that not every person taking these medicines will have a reaction. However, being aware of the potential risks allows for better monitoring and earlier intervention if symptoms appear. This knowledge empowers patients to ask questions and doctors to prescribe with confidence.