This study looked at people with Parkinsons disease who used a special skin patch called foslevodopa and foscarbidopa. The patch puts medicine directly under the skin to help control shaking and stiffness. Doctors checked how patients felt for over a year to see if the treatment worked well.
People who had not had brain surgery improved in many ways. They had less time off their medicine, slept better, and felt better overall. Their ability to move without shaking also got better during the day. These changes were clear and important for daily life.
Patients who had brain surgery before also saw some benefits. They still had less time off their medicine and slightly better sleep. However, they did not improve as much in other areas. Also, more of these patients had serious side effects compared to those without surgery.
The study found that having brain surgery earlier made side effects more likely. About 46 percent of patients with prior surgery had serious issues, while only 24 percent of others did. This difference suggests doctors should be careful when choosing this treatment for patients with previous brain operations.