Combination antifungals helped a boy with rare lung infection before transplant

This case report describes a single boy with chronic granulomatous disease who developed invasive pulmonary aspergillosis. The infection was caused by a rare fungus called Aspergillus lentulus. Doctors treated him with a combination of voriconazole and micafungin instead of standard empirical therapy. The boy became afebrile and was discharged from the hospital. He is scheduled for a hematopoietic stem cell transplantation to follow. No adverse events or discontinuations were reported during this short treatment period. Safety data are limited because this is a single case report. There are no previous cases of this specific infection in children with CGD in the literature. No consensus exists for the optimal antifungal regimen for pediatric Aspergillus lentulus infections. This report offers a practical therapeutic reference for managing this refractory fungal infection. Readers should note that evidence from one patient cannot guide general treatment decisions for others.