Mode
Text Size
Log in / Sign up

Congenital cytomegalovirus is associated with a 10-fold increased risk of vestibular changes in childrenChildren with congenital cytomegalovirus face higher risk of balance issues

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Note that cCMV is associated with a 10-fold increased risk of vestibular changes, though evidence certainty is very low.

This meta-analysis synthesized data from 8 observational studies to evaluate the impact of congenital cytomegalovirus (cCMV) on vestibular and postural balance in children aged 0 to 12 years diagnosed within the first 21 days of life. The analysis focused on identifying associations between infection and vestibular changes.

The primary finding indicates that children with cCMV have an approximately 10-fold increased risk of experiencing vestibular changes compared to a control group of children without the infection. These findings suggest a significant association between the presence of cCMV and vestibular alterations in the pediatric population.

Authors note that the evidence is characterized by very low certainty according to GRADE criteria. The results should be interpreted with caution due to this low level of certainty. There is a noted need for more well-designed research to clarify these associations.

Clinically, while the data suggest an association between cCMV and vestibular changes, the low certainty of evidence limits immediate clinical application. These findings may support the need for further investigation into pediatric vestibular screening protocols in children with confirmed congenital cytomegalovirus.

Imagine trying to navigate your world when your sense of balance feels off. For children born with congenital cytomegalovirus (cCMV), this isn't just a hypothetical problem. A review of several studies found that these children have about a 10-fold increased risk of experiencing vestibular changes compared to children without the infection. These changes affect how the inner ear helps the body stay upright and balanced.

The researchers looked at children between the ages of zero and 12 who were diagnosed with cCMV shortly after birth. While the link between the virus and balance issues is clear, it is important to know that the evidence for this finding is currently very weak. Because the data comes from a small number of observational studies, we cannot say for certain how much this affects every child.

Because of these uncertainties, experts suggest that doctors should be cautious when interpreting these results. However, the findings do point toward a need for better-designed research and more regular balance screenings for children with cCMV. If you have concerns about your child's balance or development, talk to a specialist who can provide personalized care.

What this means for you:
Children with congenital cytomegalovirus show a much higher risk of inner ear and balance issues.

Common questions

What are vestibular changes in children?

Vestibular changes refer to issues with the inner ear system, which helps a person maintain balance and posture. In this study, children with congenital cytomegalovirus (cCMV) showed an approximately 10-fold increased risk of these balance problems compared to children without the infection.

How certain is the link between cCMV and balance issues?

The evidence for this link is currently very low. Because the data comes from a small number of observational studies, doctors suggest these results should be interpreted with caution until more well-designed research can be conducted.

Who does this finding affect?

This finding specifically concerns children between the ages of 0 and 12 who were diagnosed with congenital cytomegalovirus (cCMV) through laboratory tests during their first 21 days of life.

Study Details

Study typeMeta analysis
EvidenceLevel 1
Follow-up144.0 mo
PublishedJun 2026
View Original Abstract ↓
PURPOSE: The aim of this study was to investigate the prevalence of vestibular and/or postural balance alterations in children with congenital cytomegalovirus (cCMV) and to determine the association between the infection and these impairments compared to a control group. METHOD: This systematic review was registered with Prospective Register of Systematic Reviews (CRD42024549387) and conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines consulted five databases (Embase, LILACS, PubMed/MEDLINE, Scopus, and Web of Science) and gray literature (Google Scholar and ProQuest). It included studies with children aged 0-12 years diagnosed with cCMV by laboratory tests performed in the first 21 days of life. Eligible studies assessed vestibular function and/or postural balance and compared children with cCMV with a control group of children without the infection. Only observational studies were included. A meta-analysis was performed to estimate the association between cCMV and vestibular changes, using a random-effects model and subgroup analysis. The risk of bias was assessed using the Joanna Briggs Institute checklist, and the certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool. RESULTS: The qualitative synthesis included eight observational studies of the 2,840 studies identified. All reported vestibular and/or postural balance changes in children with cCMV. The meta-analysis demonstrated an approximately 10-fold increased risk of vestibular changes in this group, especially in symptomatic children. Although the pooled risk ratio suggested a strong association, the certainty of the evidence was rated very low according to GRADE, which considers study quality, consistency, precision, and risk of bias. CONCLUSIONS: Children with cCMV, especially those with symptoms, have a significantly increased risk of vestibular and postural balance changes. However, given the very low certainty of the evidence, these results should be interpreted with caution. Future well-designed research should prioritize pediatric vestibular screening to confirm these associations and inform clinical practice.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.