A new review of 31 people with CLAPO syndrome, a rare condition that affects blood vessels and tissue growth, found that every single patient had a capillary malformation (a type of birthmark) on their lower lip. This finding confirms that the lower lip mark is a key feature of the syndrome.
The study also reported that 25 out of 31 patients had lymphatic malformations (abnormal fluid-filled spaces), 17 had venous malformations (abnormal veins), and 10 had tissue overgrowth. The researchers noted that enlarged veins on the underside of the tongue may be another clue for doctors.
Because CLAPO syndrome is very rare, the study included only 31 people. This small number means the findings may not apply to everyone with the condition. The study was a case review, not a controlled trial, so it cannot prove cause and effect.
For patients and families, this review helps clarify what to expect with CLAPO syndrome. If you or your child has these symptoms, talk to a specialist familiar with vascular anomalies.
