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Pediatric delirium affects 38% of critically ill children in meta-analysisDelirium affects 4 in 10 critically ill children

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Key Takeaway
Interpret the 38% pooled prevalence of pediatric delirium with caution due to extreme heterogeneity across studies.

This meta-analysis pooled data from 18,875 critically ill children to estimate the prevalence of pediatric delirium (PD). The overall pooled prevalence was 38.1% (95% CI: 32.5–43.8%). However, the authors caution that this figure should not be interpreted as a stable universal prevalence due to extreme heterogeneity (I2 = 98.7%) and a wide 95% prediction interval (3.6–72.4%).

Secondary analyses examined how assessment tools, sample size, income status, and study design might influence reported prevalence, but the high heterogeneity limits the reliability of any single estimate. The meta-analysis included observational studies, so no causal conclusions can be drawn.

Limitations acknowledged by the authors include the extremely high heterogeneity and the wide prediction interval, which suggest that true prevalence varies substantially across settings. Clinicians should be cautious when applying the pooled estimate to their local context.

Practice relevance: While the pooled prevalence highlights that pediatric delirium is common in critically ill children, the wide range of possible values means local surveillance and validated assessment tools remain essential for accurate diagnosis.

Imagine your child in the ICU, fighting for their life. Now imagine they're also battling a hidden brain condition that can make them confused, agitated, or withdrawn. That's pediatric delirium, and a new analysis suggests it's shockingly common.

Researchers pooled data from 18,875 critically ill children and found that 38.1% had delirium. That's nearly 4 out of 10 kids in intensive care. The condition can lead to longer hospital stays and long-term thinking problems, so catching it early matters.

But here's the catch: the numbers varied wildly from study to study. Some hospitals reported rates as low as 3.6%, others as high as 72.4%. This huge range means the true rate depends on where your child is treated, how doctors screen for delirium, and other factors we don't fully understand yet.

The takeaway? Pediatric delirium is a real and serious problem in ICUs, but we need better tools and more consistent screening to know exactly how big the problem is. If your child is in the ICU, ask the care team about delirium screening.

What this means for you:
Nearly 4 in 10 critically ill children may have delirium, but rates vary widely.

Common questions

What is pediatric delirium?

Pediatric delirium is a serious brain condition in critically ill children. It causes confusion, agitation, or withdrawal, and can lead to longer hospital stays and long-term thinking problems. It's often missed because symptoms can be subtle.

How common is pediatric delirium in critically ill children?

According to a meta-analysis of 18,875 children, the pooled prevalence is 38.1%. But rates vary widely between hospitals, from as low as 3.6% to as high as 72.4%, depending on screening methods and other factors.

Why does the prevalence of pediatric delirium vary so much?

The analysis found extremely high heterogeneity (I2 = 98.7%), meaning the results from different studies are very inconsistent. This could be due to differences in how doctors screen for delirium, the types of children studied, or hospital practices.

Should I be worried if my child is in the ICU?

Pediatric delirium is common, but the risk varies. Talk to your child's care team about delirium screening. They can monitor for signs and take steps to reduce the risk, like minimizing sedatives and keeping your child oriented.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
BackgroundPediatric delirium (PD) is a serious neurological complication in critically ill children, associated with prolonged hospitalization, extended mechanical ventilation, and increased mortality. However, the pooled prevalence of PD in this population remains unclear. This meta-analysis of observational studies aimed to determine the overall prevalence of PD among critically ill children and to identify its potential moderating factors.MethodsA comprehensive literature search was conducted in PubMed, Web of Science, Scopus, Embase, Cochrane Library, and CINAHL from inception to May 26, 2026. Methodological quality was appraised with the Joanna Briggs Institute (JBI) critical appraisal checklist for prevalence studies. Pooled prevalence of PD was calculated utilizing a DerSimonian-Laird random-effects model. To stabilize variances and improve the normal approximation, a logit transformation was applied for the meta-analysis of prevalence data. Heterogeneity was assessed using Cochran's Q test and quantified with the I² statistic. Subgroup analyses and meta-regression were conducted to explore potential sources of heterogeneity.ResultsThis meta-analysis included 40 observational studies, involving 18,875 critically ill children. The pooled prevalence of PD among critically ill children was 38.1% (95% CI: 32.5–43.8%, I2 = 98.7%, 95% PI: 3.6–72.4%). According to the JBI critical appraisal tool, 11 studies (27.5%) were rated as having a low risk of bias, 26 (65.0%) a moderate risk, and 3 (7.5%) a high risk. Subgroup analysis revealed significant variation in pooled prevalence across different assessment tools. Meta-regression suggested that prevalence was not significantly associated with sample size, income status, study design, or assessment tool.ConclusionsOur findings indicate that PD is a prevalent neurological complication among critically ill children. However, due to extremely high heterogeneity and a very wide prediction interval, this pooled estimate should not be interpreted as a stable universal figure, but merely as a summary of highly heterogeneous studies. Therefore, caution is warranted when generalizing the pooled estimate to local settings.Systematic Review Registrationidentifier CRD420261339560.
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